Endocrine Abstracts

Objective: Metformin was considered as a weight lowering agent in diabetes patients, while it remained unclear in simple obesity patients. We aimed to investigate if metformin is effective and safe in the therapy of normoglycemic obesity.Methods: We systematically searched MEDLINE (1950–2011), EMBase (1950–2011), and CCTR (4th Issue 2011), and collected and screened all randomized controlled trials compared metformin and placebo in obese partic...

Clear evidence on the specific impact of fatty acid binding proteins (FABPs) on cell biology and lipid metabolism in complex systems had been lacking until FABP-deficient mice models were created. Surprisingly, no change in appearance, gross morphology or viability was observed in FABP1-deficient mice. However, metabolic parameters in mice upon exposure to high-fat/cholesterol diet differed between studies. Therefore, liver fatty acid-binding protein (also called FABP1) plays ...

Although obesity is a powerful risk factor for developing metabolic syndrome (MetS), it is not present in all obese individuals. Increased visceral adipose tissue is the hallmark of this syndrome. In this cross sectional survey abdominal bioelectrical impedence was used to measure the visceral adipose tissue (VAT) and trunk fat percentages (TF%) in participants. A total of 286 patients (196 female and 90 males) were enrolled in the study. In both sexes VAT was significantly po...

Androgen is an important factor for determining body composition in males. Abdominal obesity is inversely correlated with serum androgen levels in men. Androgen receptor (AR) null male mice revealed late-onset visceral obesity, accompanying energy balance abnormality. We previously reported a novel synthetic steroid, S42 as a promising candidate of a selective androgen receptor modulator (SARM). When orchiectomized Sprague-Dawley rats were administered with S42 for 3 weeks, th...

Aim: We aimed to compare the cut off values, defined to express the excess total body fat (TBF) percentange and increased fat mass index (FMI) as predictors of metabolic syndrome (MS).Subjects and methods: A total of 162 obese (body mass index (BMI) >30 kg/m2) subjects’ TBF were measured by ‘Tanita TBF 300 Body Composition Analyzer’. Patients were divided into two groups called normal obese (NO) and fatty obese (FO) accordin...

Aim: Obesity prevalence increase fastly and become important health problem all around the world. Aim of our study to determine obesity and abdominal obesity prevalence in west black sea region and to display the prevalence of chronic diseases especially diabetes mellitus (DM) in obese population.Material and method: We evaluate 2222 (1418 female, 804 male, mean age 50) participant in Yigilca region. We took medical history and physical examination of al...

Introduction: Childhood cancer incidence increases all over the world, but it are optimistic that more than seventy percent of children with cancer survive due to radiation and chemotherapy. However cancer treatment may impair reproductive function. The aim of this study is to investigate level of pituitary hormones, testis/ovarian volume in women and men undergo cranial and craniospinal irradiation in childhood.Methods: Participators were examined with ...

Objective: To investigate if the event of late-onset circulatory collapse (LCC) implicated in dysfunction of adrenal steroidgenesis due to impairment of adrenal remodeling in preterm infants.Methods: Eleven in the patient group (case) with clinical signs compatible with LCC diagnosis (hypotension, oliguria, and hyponatremia) and 11 in the control group (control) matched them for gestational age without such signs. Steroids in serum were separated and pur...

Introduction: Evidence suggests a relationship between high tumoral Ki-67 LI with persistence of tumor after surgery and lower response rate to medical therapy. Therefore, we aimed to determine the relationship between Ki-67 LI and p53 with age, gender, number of surgeries, cure after surgery and cavernous sinus invasion in pituitary adenomas of patients with acromegaly.Methods: The paraffin-embedded tissue sections of 30 patiets with acromegaly, operate...

Cabergoline (CAB) and other dopamine agonists are usually discontinued shortly after hyperprolactinemic patients become pregnant. Data on maternal and foetal exposure to CAB and on recurrence of hyperprolactinemia after pregnancy are still limited. The current survey study aimed at elucidating the safety of exposure to CAB during early pregnancy and the recurrence rate of hyperprolactinemia after pregnancy. Thus, 68 pregnancies in a cohort of 59 patients with hyperprolactinemi...