Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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Page 10 of about 279 results

ea0011p786 | Thyroid | ECE2006

Epidemiology of endemic goiter in mountain region of Adjara Autonomy Republic (Georgia)

Sekhniashvili N , Kvanchakhadze R , Tsereteli D , Sekhniashvili Z , Baramidze L

2.788 inhabitant (726 men 1192 women and 870 children) were examined in mountain region of Adjara on thyroid gland pathology at the age from 1 to 75 (2003-2005 years). The investigated population was selected by ‘randomized method’. The data of ultrasonography, clinical and laboratory tests (defining T3, T4, TSH hormones, antibodies and iodine excretion in urine) were diagnostic criteria’s of thyroid gland pathology. To study risk factors of thyroid gland pathol...
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ea0011p863 | Thyroid | ECE2006

Effects of increment of endogenous TSH levels on the effective half-life time of 131I and iodine uptake by thyroid remnants in patients after thyroidectomy

Knapska-Kucharska M , Makarewicz J , Oszukowska L , Adamczewski Z , Lewinski A

The effectiveness of thyroid remnants ablation with 131I after thyroidectomy for differentiated thyroid carcinoma (DTC) depends mainly on absorbed radiation dose, which is proportional to 131I uptake (Tup) and its effective half-life time (EHL) in the remnants.Aim: Assessment of endogenous TSH level increment effects on EHL of 131I and Tup in thyroid remnants after surgery for DTC.Material: Twenty-o...
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ea0010p26 | Cytokines, growth factors, growth and development | SFE2005

Ahmed Z , Mazibrada G , Dent R , Berry M , Logan A

Upon binding of myelin-derived axon growth inhibitory ligands to the Nogo receptor (NgR), a complex is formed with LINGO-1 and the low affinity neurotrophin receptor p75NTR, which initiates axon growth cone collapse via a Rho-A-mediated pathway. We reasoned that, after tumor necrosis factor-α converting enzyme (TACE) cleavage of p75NTR, which triggers the initiation of regulated intramembrane proteolysis (RIP), signalling of growth cone collap...
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ea0008oc15 | Neuroendocrinology and Reproduction | SFE2004

PGF2alpha -FP receptor signalling is a potential regulator of endometrial vascular function

Sales KJ , Williams ARW , Anderson RA , Naor Z , Jabbour HN

Prostaglandin F2a (PGF) receptor (FP) expression is up-regulated in neoplastic epithelial and perivascular cells in endometrial adenocarcinomas, indicating potential regulation of vascular function by PGF via the FP receptor. This study investigated the potential role of PGF-FP receptor signalling in modulating vascular function in endometrial adenocarcinomas.Endometrial biopsies were obtained in accordance with Ethics Committee guidance with ...
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ea0008go2 | (1) | SFE2004

siRNA-Mediated Knock Down of NgR, p75NTR and Rho-A Disinhibits Neurotrophin-Induced Dorsal Root Ganglia Neurite Outgrowth on CNS Myelin

Ahmed Z , Dent RG , Suggate EL , Berry M , Logan A

Central nervous system neurones are generally incapable of regenerating their axons after injury due to the limited availability of neurotrophins, the development of a glial scar, and the presence of multiple axon growth inhibitors. We therefore designed short interfering RNA (siRNA) sequences to knock down components of the inhibitory signalling cascade and tested their ability to disinhibit the growth of FGF2-stimulated dorsal root ganglia neurone (DRGN) neurites in the pres...
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ea0006oc11 | Reproduction | SFE2003

EFFECT OF DIETARY N-6 POLYUNSATURATED FATTY ACIDS (PUFAS) ON PROSTAGLANDINS (PG) PRODUCED BY MATERNAL INTERCOTYLEDONARY ENDOMETRIAL (IC) TISSUES IN LATE PREGNANT EWES

Cheng Z , Elmes M , Kirkup S , Abayasekara D , Wathes D

Parturition in the ewe is initiated by the fetus following the cortisol rise via activation of the hypothalamic-pituitary-adrenal axis and increased intrauterine PG production. Dietary n-6 PUFAs, noteceably linoleic acid (LA) are the precursors for PG synthesis. The maternal intercotyledonary endometrium is the main site of PGF2alpha during labour. This study investigated the effect of dietary n-6 PUFA supplementation on uterine PG production at term. Ewes (n=32) we...
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ea0003p298 | Thyroid | BES2002

Profile of the thyroid function in a population with type-2 diabetes mellitus

Nobre E , Jorge Z , Pratas S , Silva C , Castro J

Subclinical thyroid dysfunction associated with a poor lipid profile and cardiac dysfunction. Patients with DM2 suffer from a greater risk of vascular disease, often in association dislipidemia. Thyroid dysfunction might either contribute to these factors or make them worse.Objective: To assess the prevalence of thyroid dysfunction among patients with diabetes and the relationship between that condition the control of diabetes and lipid profile.<p ...
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ea0002oc28 | Reproduction | SFE2001

EFFECT OF N-6 POLYUNSATURATED FATTY ACIDS ON PROSTAGLANDIN PRODUCTION BY OVINE UTERINE EPITHELIAL CELLS IN VITRO

Cheng Z , Elmes M , Bainbridge D , Abayasekara D , Wathes D

Polyunsaturated fatty acids (PUFAs) supply precursors for prostaglandin (PG) synthesis and PGs in turn influence many aspects of reproduction. We have previously demonstrated that supplementation of the diet of dairy cows with the n-6 PUFA [linoleic acid (LA)] significantly inhibited uterine PG production. In this study we have investigated the effects of various n-6 PUFAs in vitro on PG production by ovine endometrial cells.Endometrial tissue was...
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ea0002p34 | Diabetes and metabolism | SFE2001

Ethnic differences in the comparison of several surrogate estimates of insulin resistance and beta-cell function in healthy women

Kousta E , Efstathiadou Z , Godsland I , Johnston D , McCarthy M

Use of surrogate indices of insulin resistance depends on comparability of the relationship between glucose and insulin concentrations between different groups. It is unknown whether such surrogate estimates are equally applicable in different ethnic groups with marked differences in insulin sensitivity. We compared markers of insulin sensitivity and secretion in 78 (43 European, 19 Afro-Caribbean and 16 South Asian) normoglycaemic women of (median (lower-upper quartile)) 34.7...
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ea0029p308 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Association of PON-1 activity and other anti-oxidative enzymes with long-chain fatty acids profile in T2DM

Rasic-Milutinovic Z. , Tica J. , Gluvic Z. , Popovic-Radinovic V. , Vujovic M. , Lackovic M. , Samardzic V. , Popovic T. , Glibetic M.

Background: Serum paraoxonase-1 (PON-1) activity is decreased in clinical conditions associated with low high density-cholesterol (HDL-C), increased lipid peroxidation and low-grade chronic inflammation such as in type 2 diabetes mellitus (T2DM). Although many studies have shown that some poly unsaturated fatty acids (PUFA) modulate cardiovascular risk in T2DM, until now there is no data about the association of any fatty acid (FA) with PON-1 activity. This study aims to inves...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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