Endocrine Abstracts

The hypothalamic–pituitary unit is a particularly radiosensitive region in the central nervous system. As a consequence, hypopituitarism commonly develops after radiation treatments for sellar and parasellar neoplasms, extrasellar brain tumours. Increasing tumour-related survival rates provide an expanding population at risk of developing hypopituitarism. The severity of hypopituitarism is related to the radiation doses given while whole body irradiation regimens to a dos...

Introduction: Cushing disease (CD) is a condition due to an ACTH-secreting pituitary adenoma that is usually a microadenoma. Seldom, the lesion may be atypical by his size or his radiological aspect.The aim of this study is to analyze the clinical and biological data of CD with atypical radiological aspect (macroadenoma or other), to compare them to those of CD with a typical radiological aspect (microadenoma) and to determine the clinical or biological ...

Introduction: Subclinical hypothyroidism (SH) is associated with increased risk for atherosclerosis, mainly attributable to dyslipidemia, diastolic hypertension, altered coagulability and increased levels of inflammation markers. However, conflicting data exist regarding the effect of L-thyroxine substitution on these parameters.The purpose of the present study was to quantify the effect of L-thyroxine therapy on lipid profi...

Introduction: Excessive iodine intake can cause iodine overnutrition, goiter and other thyroid disease. This study is to probe the determinants of children’s iodine nutrition and their goitrous and nodular prevalence in areas with excessive iodine in drinking water in Hebei province of China. Methods Three townships were selected by simple random sampling among the 8 townships with median water iodine being 200–300 μg/l in Hengshui prefecture of Hebei province. ...

Severe hypothyroidism is a rare cause of precocious puberty, because long-standing primary hypothyroidism traditionally leads to both pubertal and growth delay. We report a case of a 4.7 year old girl presented with abdominal/pelvic pain and vaginal bleeding since 1 week. The child was diagnosed as a case with a right ovarian mass and was planned for surgery. She was born at term pregnancy without complication. Physical examination revealed typical features of hypothyroidism. ...

Objective: to assess the frequency and pattern of thyroid dysfunctions (TD) in Egyptian patients with chronic hepatitis C virus infection (HCV) with and without interferon alpha (IFN) therapy.Methods: thyroid function as well as thyroid peroxidase antibodies (TPO Ab) were assessed in 40 untreated Chronic HCV patients (HCV group), 30 HCV patients under IFN alpha therapy, for more than three months (IFN group) and 50 healthy age and sex matched controls.</...

Background: The accuracy of sentinel lymph node biopsy (SLNb) in decisions for surgical management of lymph nodes in differentiated thyroid ccarcinoma (DTC) was demonstarted in a few previous studies.Aim: To determine whether SLN biopsy of first draining node/s in jugulo-carotid chain is accurate technique to select patients with true positive LN for selective modified radical neck dissection (MRND).Patients and methods: We have pe...

Introduction: thyroid carcinoma is an uncommon malignancy, but it’s incidence appears to be increasing slowly (female 2–3.8/100.000 - male 1.2–2.6/100.000). This is the most common malignant endocrine tumour, represents about 1% of all malignancies. The majority of these patients females, mostly between the age of 30–60. The main differentiated histological types are papillary and follicular. The options of the treatment are surgical removal (mainly total),...

Background: Papillary thyroid carcinoma in children and adolescents is rare but it shows extremely aggressive behavior. Gross lymph node metastases and distant metastases are common on first clinical presentation.Patients and methods: Forty five children and adolescents were operated due to PTC. Mean age was 16.6 years (range 7–21). At the time of diagnosis 13% had lung metastases. Total thyroidectomy or completion of thyroidectomy was performed in ...

Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin. Procalcitonin is synthesized by a large number of tissues and organs in response to invasion by pathogenic bacteria, fungi and some parasites. Its a new and innovative parameter which reacts with high sensitivity and specificity to generalized infection and sepsis.Objective: The aim of the study was to assess PCT value for the diagnosis of systemic infection.Meth...