Endocrine Abstracts

Subclinical hypothyroidism (SH) may affect the gonadotropic axis at different levels, causing changes in the hypothalamic–pituitary unit, functions of the gonads, and changes on peripheral metabolism of sex hormones. Polycistic ovary sndrome (PCOS) is a complex endocrine syndrome characterized by the combination of reproductive aberrations, namely hyperandrogenism and chronic anovulation, with metabolic defects.The aim: To determine the role of SH a...

Aim: Studying of influence of various doses of cabergoline in dynamics of 6, 12 and 24 months of treatment on level of blood serum soluble apoptosis markers P53, Bcl-2 and TNF-α in patients with IPA.Materials and methods: One hundred and twenty-seven patients with IPA (38 men, 89 women) were observed, among them 65 (51.2%) with microadenoma and 62 (48.8%) with macroadenoma/ patients were at the age from 35 till 60 years.Patients with pituitar...

Aim: To study complications in patients with acromegaly receiving somatostatin after radiotherapy.Materials and methods: We examined 16 patients with mean disease duration 8.5±4.2 years (mean age 41.5±5.6 years) receiving distant gamma-therapy in the total dose of 60 Gy. The patients were divided into two groups: eight patients receiving somatostatin in the dose of 0.5 mg thrice a day and symptomatic therapy for 2 months were included into the ...

In July 2010, a 69-year-old woman presented because of a CT proven 5th lumbar vertebral metastasis of thyroid carcinoma and in August she underwent a total thyroidectomy and central node dissection. Histopathology revealed a moderately differentiated Hürthle cell carcinoma which was according to TNM classification pT3N1M1 tumor. Thereafter, a right hemylaminectomy of L5 and metastasectomy was performed in order to decompress the L5 and S1 spinal nerves. The histopathology...

It has been claimed that an increased level of thyroid autoantibodies in serum is associated with a higher risk for coronary heart disease (CHD). We explored whether this risk was mediated by subclinical hypothyroidism and hypercholesterolemia. We evaluated 945 consecutive hospital patients (mean age 59 years) according to strict electrocardiographic and clinical criteria for the presence of CHD. Serum cholesterol, LDL and HDL cholesterol and sensitive TSH were measured in all...

The effects of thyroid hormone deprivation and restitution on growth rate and pituitary and plasma GH levels have been studied in control and streptozotocin (STZ) – diabetic rats. GH was measured by a specific RIA using the NIAMOD rat-GH kit. Male Wistar rats which had been surgically thyroidectomized for 30 days and which had been stopped growing were injected i.p. with either saline or STZ (4 mg/100 g b.wt). Eight days after saline or STZ, groups of thyroidectomized con...

Pheochromocytomas and abdominal paragangliomas are catecholamine-producing tumors of the sympathetic nervous system, while head and neck paragangliomas are non-secreting tumors of parasympathetic origin.Here we present a case of 20-year-old patient with the metastases of malignant paraganglioma. In 2004 the disease has been detected at accidental abdominal sonography. Patient has not had any symptoms, such as headache, hyperhidrosis, palpitation, weight ...

Hyperinsulinaemia and insulin resistance play a key role in the development of the PCOS. Amenorrhoea, polycystic ovaries, hirsutism, high fasting insulin and high testosterone concentrations characterize polycistic ovary syndrome (PCOS). Hyperinsulinaemia is associated with serum C-reactive protein (CRP) levels. Elevated CRP in association with hyperinsulinemia is a significant risk factor for cardiovascular diseases.We aimed to evaluate the effect of me...

Aims This is an investigation of potential oxidative effects of AGE in response to the antioxidant glutathione in cultured human gingival fibroblasts, using radiolabelled steroids as substrates and their product 5 alpha dihydrotestosterone (DHT) as a marker of wound healing.Methods Confluent monolayer cultures of human gingival fibroblasts were incubated with 14C-Testosterone and 14C-4-androstenedione respect...

Aims Nicotine (N) has detrimental effects on fibroblasts compounding those of AGE in uncontrolled diabetes. The impact of the antioxidant glutathione (G) is investigated to clarify mechanisms involved, using 5 alpha dihydrotestosterone (DHT) as a hormone marker of healing.MethodsHuman gingival fibroblasts in confluent culture were incubated in Eagle’s MEM, with 14C-testosterone / 14C-4-androstenedione an...