Endocrine Abstracts

Public health policy in recent years has favoured a reduction in saturated fats in favour of polyunsaturated fats due to the numerous health benefits of polyunsaturated fatty acids (PUFAs). Previous studies have demonstrated that PUFAs modulate gonadal steroidogenesis. We have therefore investigated the hypothesis that PUFAs modify steroidogenesis through affecting components of the cholesterol metabolising machinery, including steroidogenic acute regulatory (StAR) protein and...

Objectives: To investigate the influence of body weight and sex on serum levels of insulin, leptin, ghrelin, IGF1, adiponectin and TSH.Methods: Serum levels of insulin, IGF1, TSH and ghrelin were measured by RIA, leptin by IRMA and adiponectin by ELISA in 90 individuals (42 women, average age 49.8±8.9 years( 48 men, average age 49.1±6.6). The sample was divided into three subgroups: normal weight (BMI=15.5–24.9), excess weight (BMI=25.0&#1...

Adrenal incidentalomas are referred as clinically silent adrenal masses discovered incidentally during diagnostic testing or treatment for conditions not related to suspicion of adrenal disease. Certain percent of them are hormonally active and autonomous cortisol secretion is reported with increasing frequency. The aim of the study was to assess value of 1mg-DST in subclinical Cushing’s syndrome (CS) compared to the other forms of adrenal incidentalomas. We have evaluate...

In the Rhône Alpes region, that hosts more than 5.6 million inhabitants; thyroid illnesses are still rather common with 3,600 operations on the thyroid gland per year, comprising 650 incident cases of cancer. A progressive increase in the incidence of thyroid cancer was suspected in the 1990 s and a population based register was initiated. The collection consists of histological data validated and obtained directly from pathologists, surgical wards and controlled through ...

Aim: The aim of this paper is to summarise the seven’s years of investigations on the frequency and kind of mutations witch occurred in gene RET in patients with medullary thyroid cancer.Methods: Within 330 subjects studied, there were 235 patients with RRT and 95 their healthy relatives. DNA was isolated from peripheral blood lymphocytes. The following exons of the gene RET were amplified by the PCR method: 10, 11, 13, 14, 15 and 16 a...

Pituitary gonadotropes (LH and FSH producing cells) are simultaneously exposed to numerous stimuli, which exert multiple signalling pathways that cross-talk with the GnRH receptor (GnRHR). A model downstream effector system is the prostanoid family. Hence, prostanoid receptors and GnRHR might cross-talk and affect the biological responses of the gonadotropes. Here we report the expression of prostaglandin (PG) PGE2 receptors EP1, EP2, EP3 and EP4, the PGF2</sub...

Objectives: To investigate whether there is a sex difference in serum leptin concentration in Chinese Type 2 diabetic patients with and without nephropathy.Methods: Early morning fasting serum leptin concentrations were measured in 34 Type 2 diabetic patients (mean age 62.1) with nephropathy (creatinine 120-450micromol/l and spot urinary albumin creatinine ratio (ACR) > 25 mg/mmol), 12 newly diagnosed diabetic subjects (mean age 62.5) with normoalbumi...

Background: Recent studies showed that cortisol autonomy is age and sex dependent and highly associated with higher all-cause mortality in patients with adrenal incidentalomas (AI). Dehydroepiandrosterone sulphate (DHEAS) has been recognized as a valuable diagnostic tool in patients with (possible) autonomous cortisol secretion.Objectives: As DHEAS levels are sex and age specific we aimed to evaluate its value as a diagnostic tool in patients with adrena...

Background: Menstrual cycle characteristics are essential indicators of a woman’s reproductive health. The reliability of auto-reported data assesment of menstrual cycle length has been questioned. Objectives: The aim was to evaluate the reliability of auto-reported data on menstrual cycle regularity. Methods: We created an anonymous survey about reproductive health and menstrual cycle characteristics and shared it with women ...

Background: It was shown that women with polycystic ovary syndrome (PCOS) are at an increased risk of COVID-19. However, it is not known whether COVID-19 has any effects on reproductive health of PCOS patients.Objectives: Aim of the study was to evaluate possible effects of COVID-19 on reproductive health in patients with PCOS.Methods: An anonymous survey about reproductive health was conducted in PCOS patients and healthy control ...