Endocrine Abstracts

Introduction: The pathogenesis of short stature and growth failure in Turner syndrome (TS) is multifactorial, and includes low birthweight, ovarian failure and skeletal dysplasia. Although abnormalities of the GH-IGF1 axis are implicated, patients are not GH-deficient (GHD) and consequently non-GHD doses of GH are utilised ie. 45–50 μg/kg per day or 9.8 mg/m2 per week. Although initially used in GHD patients, IGF1 titration is increasingly being used in al...

Background: Germline mutations in the Phosphatase and Tensin Homolog Hamartoma tumour (PTEN) gene are associated with a number of conditions, collectively known as PTEN hamartoma tumour syndromes (PHTS). Individuals with PHTS are at increased risk of a number of cancers primarily in adulthood including differentiated thyroid carcinoma (DTC) with an estimated lifetime risk of DTC of up to 38%. International guidance recommends screening commencing from 17 years while the 2017-U...

Background: In 2019, funding for continuous glucose monitoring (CGM) commenced for children and young people with diabetes (CYPD) in our region. However, there was no local established CGM structured education programme. We developed ‘the CGM Academy’ with continuous improvement using the Plan-Do-Study-Act (PDSA) cycle.Objectives: To review the PDSA cycle of improvements to deliver structured education using CGM.Methods: ...

Background: Continuous Glucose Monitoring (CGM) is now becoming the standard of care for children and young people with diabetes (CYPD). Due to a lack of validated education programmes, we created ‘The CGM Academy’ delivering evidence-based structured education. The results of the first 50 CYPD graduating from the academy demonstrated statistically significant improvement in time in range (TIR, 3.9-10.0 mmol/l) by 8.3% (P<0.001) and HbA1c by 3.8 mmol/mol...

Introduction: Language barriers can pose a significant barrier to successful education of children and young people (CYP) with type 1 diabetes (T1DM) and their families, potentially influencing their glycaemic control.Methods: Retrospective analysis from diagnosis to 18 months post diagnosis of glycaemic control in 41 CYP with T1DM requiring interpreter support (INT) under care of our diabetes centre based within a multi-ethnic community. Median HbA1c at...

Aim: Malabsorptive bariatric procedures lead to significant metabolic improvement with ongoing weight loss. The aim of our retrospective analysis was to assess the impact of bariatric surgery on three important metabolic and biochemical abnormalities associated with obesity: diabetes, liver function test (LFT), and dyslipidaemia.Methods: All patients who had laparoscopic gastric bypass (LGB) or sleeve gastrectomy (SG) over the last 7 years were identifie...

Introduction: Interpretation of renal function in patients with obesity and post-bariatric surgery is a clinical challenge. EGFR could be falsely low and weight loss does not reflect muscle mass. The aim of our study was to compare the fluctuations in renal function assessment in patients undergoing bariatric surgery.Methods: 200 patients who underwent bypass surgery or sleeve gastrectomy were analysed. Six different renal function parameters were analys...

Background: HbA1c is a marker for the risk of long-term complications of Diabetes. Our unit cares for 349 children and young people (CYP) from a population with a higher than average prevalence of low-income families, ethnic minority families, and high unemployment. Over the last 10 years there have been service improvements, increased resources and changes in practice.Aims: To review HbA1c outcomes achieved annually from 2003, compared with published na...

Introduction: Prader–Willi syndrome (PWS) is characterised by hypotonia, obesity, short stature, and hypogonadism probably due to hypothalamic dysfunction (hypogonadotropic hypogonadism (HH)). Exaggerated adrenarche is however commonly noted in these patients. Early puberty is rarely described: we report two girls with PWS diagnosed with premature sexual maturation.Case reports: Case 1: this 8-year-old girl was neonatally diagnosed with PWS (materna...

We report potential effects of antituberculosis (TB) treatment on vitamin D metabolism in the immediate postoperative period following total thyroidectomy.A 50-year woman of Chinese origin was incidentally found to have papillary thyroid carcinoma with local nodal metastasis following FDG–PET imaging done to assess nature of lung nodules on chest X-ray and CT chest. The nature of lung lesion was uncertain and commenced on empirical TB treatment (fou...