Endocrine Abstracts

Background and aims: Type 1 diabetes mellitus (T1DM) results from a severe autoimmune destruction of pancreatic beta cells, which renders patients insulin-dependent for life. The triggering of autoimmunity against beta cells is caused by a complex interaction between environmental, genetic and epigenetic risk factors. Although significant progress has been made in elucidating the genetic factors associated with T1DM, the non-genetic components have remained poorly understood. ...

In the Rhône Alpes region, that hosts more than 5.6 million inhabitants; thyroid illnesses are still rather common with 3,600 operations on the thyroid gland per year, comprising 650 incident cases of cancer. A progressive increase in the incidence of thyroid cancer was suspected in the 1990 s and a population based register was initiated. The collection consists of histological data validated and obtained directly from pathologists, surgical wards and controlled through ...