Endocrine Abstracts

Introduction: Endogenous subclinical hypercortisolism occurs in 5-30% of patients with adrenal incidentalomas. Adrenal adenoma is the commonest cause of autonomous cortisol secretion (ACS), while primary bilateral macronodular adrenal hyperplasia (PBMAH) is rare. In both, ACS results from activation of the cAMP/PKA pathway. This may be triggered by ligands, other than ACTH, acting upon aberrant G-protein coupled receptors (GPCRs), which may also control locally produced ACTH i...

Objective: Glycemic control of patients with type 1 diabetes is mainly based on insulin administration. The ongoing technological developments in continuous glucose monitoring (CGM) and continuous subcutaneous insulin infusion (CSII) provide new treatment strategies, with better glycemic control. This study assessed the clinical impact of two treatment strategies in adults with type 1 diabetes (T1D): multiple daily insulin injections (MDII) vs continuous subcutaneous insulin i...

Background: Pheochromocytomas are catecholamine-producing neuroendocrine tumors, arising from the adrenal medulla or from paraganglionic chromafin tissue. Their clinical presentation, mainly attributable to the increased catecholamine production and it is highly variable. We herein present a case of a 42-year-old female patient with recurrent episodes of Takotsubo cardiomyopathy due to a pheochromocytoma.Case presentation: The patient presented two years...