Searchable abstracts of presentations at key conferences in endocrinology
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25th European Congress of Endocrinology

Istanbul, Turkey
13 May 2023 - 16 May 2023

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ECE 2023 will be held in Istanbul, Turkey from 13-16 May 2023. Istanbul is known for its rich culture, historical sites and dynamic nightlife, and we are excited to come together in this city, and look forward to meeting old friends, making new ones, and sharing science, collaborations and ideas.

Poster Presentations

Diabetes, Obesity, Metabolism and Nutrition

ea0090p53 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

The concentration of Polycyclic Aromatic Hydrocarbons (PAHs) in human serum and adipose tissues and In Vitro stimulatory effect of naphthalene in adipogenesis in 3T3-L1 cells

Mlyczyńska Ewa , Bongrani Alice , Rame Christelle , Węgiel Małgorzata , Maślanka Anna , Major Piotr , Zarzycki Piotr , Ducluzeau Pierre-Henri , De Luca Arnaud , Bourbao-Tournois Celine , Froment Pascal , Rak Agnieszka , Dupont Joelle

Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants derived from the incomplete combustion of organic materials. In urban and industrial areas, level of pollution with these compounds is high, which leads to numerous negative health effects. Some literature data indicate the involvement of PAHs in the development of obesity, however, there is no data showing the distribution patterns of PAHs in human adipose tissue (AT) and their impact on the process o...

ea0090p54 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Continuous Glucose Monitoring in Hospitalized Type 2 Diabetes Patients

Verissimo David , Vinhais Joana , Machado Vania , Silva Sandra , Ivo Catarina , Claudia Martins Ana , Silva Joao , Passos Dolores , Lopes Luis , Jacome Castro J , Marcelino Mafalda

Introduction: Continuous glucose monitoring systems (CGM) have revolutionized the monitoring of diabetes, allowing real-time measurement of interstitial glucose levels. Although these devices are suitable for patients on insulin therapy, they are not yet routinely used in an inpatient setting. The difficulty observed in the glycemic control of hospitalized patients under intensive insulin therapy led to the development of a protocol to study the application of CGM in these pat...

ea0090p55 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Ceramides In Epicardial Adipose Tissue from Coronary Diabetic Patients: New Markers of Tissue Metabolism?

Berg Gabriela , Campos Jeanniel , Ancel Patricia , Svilar Ljubica , Patricio Nogueira Juan , Dutour Anne , Charles Martin Jean , Gaborit Benedicte , Rubio Miguel , Schreier Laura , Barchuk Magali

Ceramides (Cer), which are known to be altered in plasma before the onset of coronary artery disease (CAD), have been proposed as new markers for cardiovascular disease (CVD) risk. Serum Cer18:1/C16:0, Cer18:1/C18:0 and Cer18:1/C24:1 to Cer18:1/24:0 indexes are proposed to be indicative of CAD. Epicardial adipose tissue (EAT) is a visceral adipose tissue, surrounding and in direct contact with the myocardium and coronary arteries, which volume is considered a risk factor for C...

ea0090p56 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Long-Term Diabetes Remission Rates In A Group of Type 2 Diabetic Patients After Sleeve Gastrectomy and Rou and Y Bypass Metabolic Surgery: A Single-Centered Experience

Saydam Simge , Tuğberk Bakar Murat , Erol Tuğce , Gogas Yavuz Dilek

Introduction: Various rates were reported regarding diabetes remission and improvement in hyperglycemia in many studies from different populations. Determinants of diabetes remission have not been definitively established so far. In this study, we aimed to evaluate the long-term glycemic status after bariatric surgery in diabetic obese patients followed by Marmara University Endocrinology Outpatient Clinic.Method: The retrospective study included 233 typ...

ea0090p57 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

A Quality Improvement initiative to assess differences of diabetic ketoacidosis (DKA) management across hospitals in the United Kingdom

Dalzell Joseph , Skaria Maria , Kauser-Malik Saima , Raghavan Rajeev , Soghal Shamanth , Tabasum Maria , Ahmed Nabeel , Nizza Jael , Acharya Jayashekara , Saraf Sanjay , Dekode Team

Background: Joint British Diabetes Societies (JBDS) have developed guidelines for the treatment and management of diabetic ketoacidosis (DKA) in adults in the United Kingdom (UK). Multiple single center audits are known to assess compliance to guidelines. However, unified data on DKA management across multiple centers is unknown.Aims: To study the precipitating factors and assess for differences in DKA management across UK hospitals.<p class="abstext...

ea0090p58 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Vitamin B12 and diabetic peripheral neuropathy in type 2 diabetic patients

Adel Meriem , Jemel Manel , Chiboub Marwa , Grassa Anis , Ellouz Amel , Kandara Hajer , Kammoun Ines , Mahjoub Rahma , Talbi Emna

Introduction: Metformin is a cornerstone in the treatment of type 2 diabetes, but in recent years several studies have shown that metformin use is associated with a 4-24% decrease in vitamin B12 levels. It is estimated that this problem occurs in approximately 10-30% of patients using metformin and may contribute to distal symmetrical polyneuropathy (DSPN), a very common and clinically relevant diabetic complication.Objective: To study vitamin B12 concen...

ea0090p60 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Diabetes and associated risk factors for cardiovascular mortality in Cuba: prospective study of 146,556 participants

Iglesias Ileydis , Barbara Armas Rojas Nurys , Lewington Sarah , Lacey Ben , Peto Richard , Burret Julie , Diaz Diaz Oscar

Background: Cardiovascular disease accounts for about one-third of all premature deaths (ie, age <70) in Cuba. Yet, the relevance of major risk factors, including diabetes, systolic blood pressure (SBP), and body-mass index (BMI), to cardiovascular mortality in this population remains unclear.Methods: In 1996–2002, 146,556 adults were recruited from the general population in five areas of Cuba. Participants were interviewed, measured (height, we...

ea0090p61 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

The dual GIP/GLP-1 receptor co-agonist Tirzepatide vs GLP-1 receptor agonists as add-on to basal insulin in uncontrolled type 2 diabetes mellitus: A rapid review of randomized controlled trials and meta-analysis

Lisco Giuseppe , De Tullio Anna , Disoteo Olga , De Geronimo Vincenzo , Piazzolla Giuseppina , De Pergola Giovanni , Angelo Giagulli Vito , Jirillo Emilio , Guastamacchia Edoardo , Sabba Carlo , Triggiani Vincenzo

Tirzepatide, a once-weekly dual co-agonist of Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide 1 (GLP-1) receptors, has been demonstrated to improve glucose control and reduced body weight in different therapeutic approaches. With this rapid review and meta-analysis, we systematically reviewed the efficacy and safety of injectable incretin-based therapy added to basal insulin compared to basal insulin plus background treatments titrated rigorously t...

ea0090p62 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Utility of using Continuous Glucose Monitoring based MetaSense in OneCare Diabetes care program in driving the metabolic outcomes in People with Diabetes Mellitus – A real world data from urban India

G S Basavaraj , Fatema Zareen , DM Mahesh , Dasyam Srinivas , BS Narendra

Background: As adoption of continuous glucose monitoring (CGM) continues to expand, lot more studies are investigating the effects of CGM on HbA1C and hypoglycaemia risks in people with Diabetes Mellitus (PwD). In PwD, established benefits of usage of CGM along with digital diabetes self-management and education (DSME) program in Indian real-world context are scarce. OneCare compares patients engaged in its “IMPACT’ DSME program alone vs program assisted by CGM.<...

ea0090p63 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Left hemiparesis and urinary incontinence as presentation of pancreatic Insulinoma in a young female. A Case report and review of literature

Cerma Adishah , Kermaj Marjeta , Ylli Agron

Introduction: Insulinoma is a rare tumor, with peak incidence at 30 -60 years of age and more frequent in women. It is associated with a myriad of clinical manifestations: from clearly defined adrenergic and neuroglycopenic symptoms to asymptomatic hypoglycemia. We present the case of a 20-year-old patient with pancreatic insulinoma, which was surgically resected only after her second hospitalization due to repeated negative imaging.Case presentation: A ...

ea0090p64 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Covid-induced relapse of exogenous insulin autoimmune syndrome successfully treated with Rituximab and plasmapheresis

Frikha Hamdi , Mnif Mouna , Ben Salah Dhoha , Dhieb Nesrine , Elleuch Mouna , Mnif Fatma , REKIK Majdoub NABILA , Charfi Nadia , Haj Kacem Akid Faten , Abid Mohamed

Introduction: Exogenous insulin autoimmune syndrome (EIAS) is a rare cause of hypoglycemia in patients with diabetes treated with exogenous insulin. Flares of auto-immune diseases following covid-19 infection have been widely reported.Case report: A 15-year-old type 1 diabetes female patient treated with detemir and glulisine was diagnosed with EIAS based on major glycemic instability and an elevated anti exogenous insulin autoantibody titer of 40 IU (NV...

ea0090p65 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Gender differences in smoking cessation? Results of a randomized controlled trial of dulaglutide-assisted smoking cessation

Baur Fabienne , David Coynel , Atila Cihan , Lengsfeld Sophia , Burkard Thilo , Meienberg Andrea , Bathelt Cemile , Christ-Crain Mirjam , Winzeler Bettina

Introduction: Smoking harms women more than men and women seem to be less successful in quitting. Greater concerns about post-cessational weight in women and gender differences in craving and reward processing have been postulated as possible explanations. Our group recently showed that the GLP-1 analogue dulaglutide reduces post-cessational weight gain. We hypothesize that women compared to men might profit more from the weight-lowering effects of dulaglutide in terms of abst...

ea0090p66 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Weight Outcomes With Setmelanotide Over 3 Years in Patients With POMC or LEPR Deficiency Obesity

Clement Karine , Wabitsch Martin , van den Akker Erica , Argente Jesus , Navarria Andrea , Srinivasan Madhura , Yuan Guojun , Malhotra Sonali , Kuhnen Peter

Background: Rare variants in the melanocortin-4 receptor (MC4R) pathway are associated with early-onset, severe obesity and hyperphagia. Setmelanotide, an MC4R agonist, reduced body mass index (BMI) and decreased hunger in patients with obesity due to biallelic variants in genes encoding proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) in Phase 3 trials. The current analysis assesses the durability of setmelanotide ef...

ea0090p67 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Study of the prevalence, clinical correlates, and cardiovascular outcomes of central and primary hypogonadism in type 2 diabetes mellitus

Cangiano Biagio , Elena Lunati Maria , Bollino Ruggiero , Conti Antonio , Galazzi Elena , Fiorina Paolo , Persani Luca , Bonomi Marco

Background: In patients affected with type 2 diabetes mellitus (T2DM) a high prevalence of hypogonadism has been reported, even if there is no consensus on its metabolic and cardiovascular implications, especially according to the type of hypogonadism. The aim of this observational study is to evaluate: (1) the prevalence of different types of hypogonadism in T2DM according to validated criteria from the EMAS study; (2) look for correlations of gonadal status with severity or ...

ea0090p68 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

A Challenging Case of Diabetic Ketoacidosis Due to Thyrotoxicosis

Kalantzi Athanasia , Barlampa Danai , Kaliakatsou Eirini , Tsironi Ioanna , Papanastasiou Labrini , Kounadi Theodora , Markou Athina

Purpose: To present a rare case of diabetic ketoacidosis due to thyrotoxicosis and massive pulmonary embolism.Case presentation: A 40-year-old man from Cameroun, with history of type 2 diabetes treated with gliclazide and metformin, presented with vomiting and abdominal pain. His vital signs were: blood pressure 140/80 mmHg, heart rate 184 beats per minute and temperature 38.2 °C. On admission, laboratory investigation revealed hyperglycemia, hypero...

ea0090p69 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Effects of Glucagon-Like Peptide-1 Analogs on Sexual Desire: A randomized, double-blind, placebo-controlled crossover trial

Lengsfeld Sophia , Hasenbohler Flavia , Probst Leila , Baur Fabienne , Emara Yara , Bathelt Cemile , Werlen Laura , Vogt Deborah , Caviezel Brida , Vukajlovic Tanja , Christ-Crain Mirjam , Winzeler Bettina

Background: GLP-1 analogs are prescribed for diabetes and obesity due to their well-known insulinotropic, satiation-promoting and appetite-suppressant effects. Several studies also investigated the effects of GLP-1 analogs on reward to addictive drugs such as alcohol, nicotine and cocaine. Pre-clinical studies suggest that sexual desire, as another type of natural reward, could also be affected by GLP-1 analogs. Since sexuality is a very important aspect of human wellbeing and...

ea0090p70 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Association between advanced glycation end products (AGEs) and diabetic retinopathy in Latvia

Svikle Zane , Peterfelde Beate , Petersone Dace , Nagobade Renate , Janceva Julija , Valeinis Janis , Baumane Kristine , Sokolovska Jelizaveta

Background: Diabetic retinopathy is a common complication of diabetes mellitus and the leading cause of blindness in the working-age population in the developed world. Novel biomarkers are needed to improve the screening efficiency for the prevention and early treatment of this condition. Accumulation of advanced glycation end products (AGEs) is considered as one of pathogenetic pathways in development of diabetic complications. AGEs are formed in the process of non-enzymatic ...

ea0090p71 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Protective Role of Matrix Metalloproteinase-2 -1306 C/T and -1575 G/A Gene Polymorphisms Against Type 2 Diabetes Mellitus: A Case Control Study

Sarray Sameh , Dallel Meriem , Ben lamine Laila , Sellami Nejla , Turki Amira , Brock Roland , Ghorbel mohamed

Aims: Genetic variations mediating matrix metalloproteinase-2 (MMP-2) expression may result in individual differences in susceptibility to particular diseases. Our aim was to investigate the possible association of certain MMP-2 gene variants with type 2 diabetes mellitus (T2DM) in a Tunisian population.Subjects and Methods: A case-control study involving 310 normoglycemic control subjects and 791 T2D patients was performed. A total of four MMP-2 SNPs (-...

ea0090p72 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Clinical profiling of Acanthosis nigricans in Emirati patients and its association with sex-specific differences in insulin secretion and insulin resistance: a case-control study

Al-Olabi Lara , Alkaf Budour , Buckley Adam J.

Background: Acanthosis nigricans (AN) is a cutaneous condition characterised by pigmented hyperkeratosis of the skin flexures and neck and occurs most commonly in association with hyperinsulinaemia and insulin resistance (IR). A high prevalence of hyperinsulinaemia and abnormal glucose intolerance has been reported in the Emirati population. Current knowledge of AN suggests that it is a strong visible cutaneous marker associated with IR and can precede the onset of hyperglycae...

ea0090p73 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Paediatric Type 2 Diabetes in a single centre in East London in the period 2008-2018

Abdelhameed Farah , Giuffrida Anna , Thorp Ben , Moorthy Myuri , Gevers Evelien

Objective: Incidence of paediatric type 2 diabetes appears to be increasing. We describe our cohort of paediatric type 2 diabetes at Barts Health NHS Trust in East London (UK) over the period 2008-2018 to gain insight in incidence, complications and outcomes.Methods: Retrospective cohort study. Data collection from Twinkle (electronic database for diabetes) and paper notes.Results: Fourty patients (25 female) were diagnosed with T2...

ea0090p74 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Assessment of insulin-releasing and glucose-lowering actions of aqueous extracts of Pterocarpus mildbraedii cellular and diet-induced mice models of type 2 diabetes

Ojo Opeolu , Benjamin Falana Ayokunle , Abiodun Falobi Ayodele , Kaur Heer Simren , Adie Mojisola , Nneka Edeani Joy , Anyanwu Gabriel , Ejike Uju

Aim: The use of commonly consumed vegetables, such as Pterocarpus mildbraedii, in the treatment of metabolic conditions is consistent with the food-as-medicine strategy. To characterise its pharmacological actions, this study assessed insulin-releasing and glucose lowering effects of effects of P. mildbraedii in models of type 2 diabetes.Methods: Clonal pancreatic cells, BRIN-BD11, were treated P. mildbraedii extracts...

ea0090p75 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Acceptability of the switch from parenteral to oral semaglutide in patients with type 2 diabetes mellitus and obesity: Patient satisfaction, and changes in HbA1c, body weight, systolic blood pressure and tryglicerides

Javier Martinez Martin Francisco , Santana Ojeda Borja , Rios-Gomez Carlos , Jose de Leon-Durango Ricardo , Hernandez-Lazaro Alba , Arnas-Leon Claudia , Acosta-Calero Carmen , Kuzior Agnieszka , Martin-Perez Marta , Garcia-Alamo Debora

Introduction: During most of the autumn of 2022, the standard maintenance presentation of parenteral semaglutide (1.0 mg for weekly dosage) was temporarily unavailable. Many of the patients using this dose were switched to the standard maintenance dose of oral semaglutide (14 mg daily). The leaflet included with the product specifies that the 14 mg daily oral dose is equivalent to the 0.5 mg parenteral weekly dose, but this is most likely an interpolation, as there are no repo...

ea0090p76 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Very-low-calorie-ketogenic-diet (VLCKD) as a nutritional therapeutical option for chronic management in obese patients with type 2 diabetes: a case report

Parazzoli Chiara , Volpi Graziella , Morpurgo Paola S. , Gandolfi Alessandra , Mario Bolla Andrea , Fiorina Paolo

Introduction: It is known that very-low-calorie-ketogenic-diet (VLCKD) has beneficial effects on body weight in overweight diabetic patients. Adopting this diet with artificial meals or natural foods in type 2 diabetes (T2DM) has been largely studied, and conflicting results have been reported regarding its effects on glycemic profiles, dyslipidemia, and liver function. In fact, the high level of fat content in natural foods could have a negative impact on hepatic steatosis, a...

ea0090p77 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

En route to sarcopenia biomarkers: dp-ucMGP in relation to muscle mass and function

Tandl Veronika , Schweighofer Natascha , Trummer Olivia , Haudum Christoph W. , Lind Alice F. , Kolesnik Ewald , Mursic Ines , Scherr Daniel , Zirlik Andreas , Pieber Thomas R. , Verheyen Nicolas D. , Obermayer-Pietsch Barbara

Sarcopenia is characterized by progressive loss of both mass and function of skeletal muscle when ageing. It poses a serious issue for healthcare systems, as it is associated with increased risk of falls, osteoporosis, and mortality. To date, no ideal serum biomarkers for the diagnosis of this complex condition have been identified. Matrix-GLA-protein (MGP), primarily known as a vitamin K dependent calcification inhibitor, is present and active in bone, muscle, and adipose tis...

ea0090p78 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Epicardial Fat, a cardiovascular risk factor with implications in kidney function

Perdomo Carolina M. , Martin-Calvo Nerea , Ezponda Casajus Ana , Mendoza Francisco J. , Bastarrika Aleman Gorka , de Assuncao Guilherme V. , Garcia-Fernandez Nuria , Fruhbeck Gema , Escalada Javier

Aim: Epicardial adipose tissue (EAT) has important physiologic functions, nonetheless, excessive EAT leads to a proinflammatory state with adverse effects on the myocardium. EAT has also been associated with adverse outcomes in chronic kidney disease (CKD) patients. We think that visceral adipose tissue (VAT) and organ-specific ectopic fat plays an important role in cardiorenal dysfunction. The aim of our study is to analyse the relationship between EAT and the risk of develop...

ea0090p79 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Central Actions of Leptin Sensitizer Celastrol

Bernecker Miriam , Schriever Sonja , Pathak Ekta , Sterr Michael , Lickert Heiko , Yue Jessica , Pfluger Paul

Celastrol, a triterpene compound derived from the thunder god vine (Tripterygium wilfordii), has shown promising efficacy in preclinical models for the management of metabolic disorders such as obesity and diabetes. The compound exhibits anti-inflammatory properties and has been shown to enhance insulin sensitivity and modulate lipid metabolism. The observed weight loss effects are thought to be primarily mediated by its ability to augment leptin sensitivity. Despite extensive...

ea0090p80 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Cardiac Autonomic Regulation and Metabolic Syndrome: Clinical Use of A Unitary Autonomic Nervous System Index

Giovanelli Luca , Malacarne Mara , Bernardelli Giuseppina , Ardigo Alessandro , Solaro Nadia , Lucini Daniela

Background: Metabolic syndrome (MetS) represents a huge public health problem worldwide, being associated with an increased risk of cardiovascular and oncological diseases, and all-cause mortality. There is compelling evidence supporting a key role of dysfunctional autonomic nervous system (ANS) in such an association as well as the mutual correlation between the components of MetS. Autonomic Nervous System Index (ANSI) is a percent ranked (0–100) unitary proxy of cardiac...

ea0090p81 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Early impact of bariatric surgery on obesity-related kidney dysfunction

Maria Popa Miruna , Sirbu Anca , Malinici Elisabeta , Sorina Martin Carmen , soare iulia , Gabriela Barbu Carmen , Copaescu Catalin , Fica Simona

Background: Renal dysfunction is known to be more prevalent amongst patients with obesity. Metabolic and bariatric surgery is associated with positive renal effects through intricate pathways. We aimed to determine the short-term impact of laparoscopic sleeve gastrectomy (LSG) on renal function and to identify parameters associated with its variation.Materials and methods: We performed a retrospective study on 268 patients (115 males and 153 females) eva...

ea0090p82 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Testosterone serum levels predict the severity of metabolic dysfunction associated fatty liver disease (MAFLD) in hypogonadal men

Santi Daniele , Spaggiari Giorgia , Nascimbeni Fabio , Lugari Simonetta , Felicani Cristina , Dalla Valentina Leonardo , Ahmad Ali , Raffaele Michele Granata Antonio , Andreone Pietro , Simoni Manuela

Background: Metabolic dysfunction associated fatty liver disease (MAFLD), the leading cause of chronic liver disease, is defined as the presence of hepatic steatosis and metabolic risk factors. Both testosterone and estradiol seem to have a pivotal role in hepatic lipid homeostasis, although underlying mechanisms are still unclear. Low testosterone serum levels result independently associated with MAFLD, but no studies so far evaluated MAFLD prevalence and severity in hypogona...

ea0090p83 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Understanding the cultural fit of the REDE model for physician-based communication skills training: A focus group discussion with South Indian patients with T2DM

Selvan Chitra , Lathia Tejal , Chawak Shweta , Katdare Praneeta , Chittem Mahati

Background: In India, physicians recognise the need for communication skills training (CST) so as to improve patients’ physical and mental wellbeing. Yet, there is a lack of culturally informed and evidence-based training programs in the current medical curriculum. In our pilot study, we explored the cultural suitability of the Relationship: Establishment, Development and Engagement (REDE) model for CST for Indian physicians. The REDE model proposes three ways (i.e., esta...

ea0090p85 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Glycemic variability in type 1 diabetics treated with human insulin

Mahjoub Faten , Bani Ines , Ben Amor Nadia , El Amri Abir , Mizouri Ramla , Ben Othman Rym , Henda Jamoussi

Introduction: Type 1 diabetes is an endocrinopathy due to insulin deficiency. Its treatment consists in administering an exogenous insulin simulating the physiological secretion. The objective of this study was to evaluate glycemic variability in a group of adolescents with type 1 diabetes treated with human insulin.Method: This is a cross-sectional study, including type1 diabetic patients treated with human insulin, who underwent continuous glucose moni...

ea0090p86 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Depressive Symptoms in Patients With Type 1 and Type 2 Diabetes: prevalence and associated factors

Khalaf Rahma , Khamassi Sana , Boukhayatia Fatma , Achwak Mehrez , Dhieb Nesrine , Abdesselem Haifa , Ounaissa Kamilia , Amrouche Chiraz

Background and Aim: Patients with type1 and type2 diabetes both have a high prevalence of depressive symptoms. The aim of this study was to evaluate the prevalence of depressive symptoms and associated factors in patients with diabetes.Methods: This is a cross-sectional study conducted in 140 patients with diabetes. Patients’ demographic characteristics, current treatments, glycemic control, cardiovascular risk factors, diabetes-related complication...

ea0090p87 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

IADPSG Vs Carpenter and Coustan Criteria for the Diagnosis of Gestational Diabetes Mellitus in a Spanish Population: Is it Worth Switching?

Martin Borge Virginia , Mira Sharona Azriel , Garcia-Riano Garcia Taida , Rubio Valtuena Jose , Garcia Romero de Tejada Gema , Antonio Balsa Rubio Jose

Objective: The aim of this study was to evaluate maternal and perinatal outcomes before and after implementation of the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria for testing of gestational diabetes mellitus (GDM).Methods: This is a retrospective cohort study of women with GDM followed at a single university hospital. We compared maternal and neonatal outcomes of singleton pregnancies in women with GMD before (from...

ea0090p88 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Substantial Burden Associated With Hyperphagia and Obesity in Children With Bardet-Biedl Syndrome

Haws Robert , Pomeroy Jeremy , Mallya Usha G. , Buckley Brieana , Faucher Ariane , Kyle Ryan

Background: Bardet-Biedl syndrome (BBS) is a rare melanocortin-4 receptor (MC4R) pathway disease characterized by early-onset, severe obesity and hyperphagia associated with primary cilia dysfunction. Patients with rare MC4R pathway diseases of obesity and hyperphagia, including BBS, experience high disease burden, but the relationship between hyperphagia and body weight in patients with BBS is not fully understood. We assessed the correlation between hyperphagia score and obe...

ea0090p89 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Indications that the vitamin D-endocrine system is altered in obese people

Kumar Subhash , Guha Shaibal , Kumar Das Amit

Background: In obese patients compared to non-obese subjects, serum immunoreactive parathyroid hormone (PTH) is higher and decreases with weight loss.Objectives: To find out if obesity affects the vitamin D endocrine system and if the resulting secondary hyperparathyroidism is linked to a decrease in urine calcium.Material and Methods: 25 healthy individuals were examined. Between the ages of 21-30 years, there were 13 obese people...

ea0090p90 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Does intermittent fasting improves metabolic and inflammatory parameters in obeseadult ?

Mahjoub Faten , Arij Bejaoui , Ben Amor Nadia , Bani Ines , Dhieb Nesrine , Mizouri Ramla , Ben Othman Rym , Henda Jamoussi

Introduction: During these last years, Intermittent fasting was emerging as an approach that improves weight and metabolic outcomes in obese subjects.Objective: To investigate the effects of 16:8 intermittent fasting on metabolic and inflammatory parameters in adult obese.Methods: This is a comparative interventional study conducted in 60 obese women consulting the obesity unit of the Institute of Nutrition of Tunis during the peri...

ea0090p91 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Vitamin D supplementation reduces oxidative stress caused by hyperuricemia in type 2 diabetes mellitus patients

Alfaqih Mahmoud A. , Ababneh Ebaa , Sater Mai

Introduction: It is suggested that hyperuricemia in type 2 diabetes (T2DM) patients causes reactive oxygen species (ROS) accumulation, which causes the destruction of beta cells of the pancreas and contributes to T2DM. This study aimed to analyze the relationship between vitamin D deficiency (which is reciprocally related to Serum Uric Acid (SUA) levels), hyperuricemia, and levels of ROS scavengers in T2DM patients, and to investigate the effect of vitamin D supplementation on...

ea0090p92 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

A study to evaluate clinical and metabolic profile in a type 1 diabetes cohort receiving dpp4 inhibitor plus SGLT2 inhibitor compared to either drug alone as an adjuvant therapy

Dev K Chethan , Kumar Sethi Bipin

Introduction: There is always been a need for safe and effective adjuvant therapy in type 1 Diabetes not just for glycemic control but also for cardio-renal benefits.Objectives: To evaluate whether addition of DPP-4 inhibitors reduces the ketogenic potential of SGLT2i when used as an adjuvant therapy in type 1 Diabetes.Materials & Methods: 20 type 1 Diabetes subjects above 18 years of age with poorly controlled glycemia (HbA1c ...

ea0090p93 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Development and Validation of Blood Glucose Measurement Knowledge Scale - BGM-Knowledge Scale

Celik Selda , Bulbul Elif , Erdem Esin , Gokmen Derya

Aim: Self-monitoring of blood glucose has an important place in ensuring diabetes management. This study aims to develop a reliable instrument to assess blood glucose measurement knowledge in diabetic patients. The purpose of the scale is to assess blood glucose measurement knowledge in diabetic patients.Method: The data were collected from 240 patients in the diabetes polyclinic of a training and research hospital between March and September 2022. The s...

ea0090p94 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Higher SHBG, Apo A1, HDL and adiponectin might be connected with lower cardiovascular risk in women with type 1 diabetes and LADA

Ljubic Spomenka , Jazbec Anamarija , Bulum Tomislav , Tomic Martina , Rahelic Dario

Aim: Low sex hormone-binding globulin (SHBG) is accompanied with onset of diabetes (DM) and increased cardiovascular risk (CVR). Proinflammatory cytokines, including adiponectin (APN) influence SHBG production. Lipid accumulation product (LAP) advocates as an indicator of increased CVR. We investigated the influence of different types of DM and sex on CVR through changes in SHBG and related risk factors.Methods: Due to the non-normal distribution of indi...

ea0090p95 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Machine learning-derived low density lipoprotein cholesterol (LDL-C) estimation agrees better with directly measured LDL-C than conventional equations in individuals with type 2 diabetes mellitus.

Sng Gerald , Khoo You Liang , Tan Hong Chang , Mong Bee Yong

Introduction: Elevated low-density lipoprotein cholesterol (LDL-C) is an important risk factor for atherosclerotic cardiovascular disease (ASCVD). Direct LDL-C measurement is not widely performed. LDL-C is typically estimated using the Friedewald (FLDL), Martin-Hopkins (MLDL) or Sampson (SLDL) equations, which may be inaccurate at high triglycerides (TG) or low LDL-C levels. We aimed to determine if machine learning (ML)-derived LDL-C levels agree better with direct LDL-C than...

ea0090p96 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Development and Validation of the Blood Glucose Measurement Competence Evaluation Form- BGM-CEF

Celik Selda , Bulbul Elif , Erdem Esin , Gokmen Derya

Aim: Self-monitoring of blood glucose has an important place in ensuring diabetes management. For diabetic individuals to measure their blood glucose level correctly with recommended frequency and technique, their blood glucose measurement technique, knowledge, and skills should be checked regularly with reliable measurement tools. This study aimed to develop a reliable instrument for assessing blood glucose self-monitoring skills in diabetic patients. The purpose of the scale...

ea0090p97 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Bruns-Garland syndrome (diabetic amyotrophy) associated with SGLT2 inhibitor and its rapid HbA1c improvement: a case-report

Nagarajah kalyani , Panagiotou Grigorios , Karen Platts Julia

Background: Bruns Garlands syndrome is a rare disorder in people living with diabetes, manifesting as unilateral or bilateral muscle pain, weakness and atrophy in the proximal region of the lower limbs. Herein, we present the case of a patient with Bruns-Garland syndrome caused by sodium/glucose co-transporter 2 inhibitors (SGLT2i).Case description: A 55-year-old male with background of type 2 diabetes for 5 years, and currently on oral therapy, presente...

ea0090p98 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Investigation of Brain CD47 Expression and Its Relation with Cognitive Functions in Diabetic Mice Models

Kiriscioglu Nil , Asadi Amirhooman , Guven Mucahit , Ozkan Esra , Kocabay Ahmet , Deyneli Oguzhan , Yazici Dilek , Tutuncu Yildiz

Background: Diabetes Mellitus (DM) is an endocrine disorder resulting in hyperglycaemia that affects many vital organs of the body like the brain. The molecular mechanisms underlying dementia, memory loss and cognition dysfunction caused by DM are still not very clear. CD47 is a cell surface protein working in the homeostasis of the immune system. The causal relationship of CD47 has been shown in neurodegenerative diseases. CD47 also has a role in pancreatic islet cells and th...

ea0090p99 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Debilitating post-prandial hypoglycaemia as a sole presentation of coeliac disease responding to gluten free diet and plasma exchange for autoimmune neuromyotonia

Aslam Hina , Green Mark , Clarke Emily , Bujanova Jana , Umer Malik Muhammad

Post-prandial hypoglycaemia (PPH) can be associated with debilitating symptoms. Causes include altered physiology post-bariatric and upper gastrointestinal (GI) surgery and rarely noninsulinoma pancreatogenous hypoglycemia syndrome and insulin antibodies. We present a case of 49y female with no prior GI surgery presenting with debilitating hypoglycaemia with blood glucose falling to 2.8 mmol/l responding to glucose. Freestyle Libre monitoring confirmed hypoglycaemia 2-3 h post...

ea0090p100 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Gastrointestinal symptoms in patients with Diabetes Mellitus: Prevalence and associated factors

Khalaf Rahma , Olfa Berriche , Khamassi Sana , Dhieb Nesrine , Mizouri Ramla , Ben Amor Nadia , Ben Othman Rym , Gamoudi Amel , Kacem Awatef , Henda Jamoussi

Backgroud and Aim: Gastrointestinal (GI) symptoms are reportedly common in diabetes mellitus (DM) with a conflicting data on its prevalence in this specific population. The aim of our study is to determine the prevalence of GI symptoms and its associated factors.Methods: This is a cross-sectional study conducted on 60 patients with DM. Anthropometric parameters, glycemic control, duration of diabetes and diabetic treatment were collected. Lower and upper...

ea0090p101 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Role of C-peptide, body mass index and age in classification of diabetes

Chadia Zouaoui , Hadj Sliman Chayma Bel , Najla Bchir , Myriam Baltagi , Benchhida Annam , Ouertani Haroun

Introduction: Classification of diabetes is challenging in some cases, especially in the presence of inaugural ketosis with a negative autoimmune laboratory test. The aim of our study is to determine the role of age, body mass index (BMI), and fasting plasma C-peptide (FCP) in the classification of diabetes.Methods: This is a descriptive cross-sectional study that included 51 patients aged between 20 and 65 years hospitalized at the Endocrinology Departm...

ea0090p102 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

People With Newly Diagnosed T2DM Showed Significant Improvement in Glycemic Control and Effective Weight Management After Completion of Fitterfly Diabetes Digital Therapeutics Program

Lathia Tejal , Verma Ritika , Khader Mohammed Abdul , Selvan Chitra , C S Dwarakanath , Aggarwal Ajay , Ghanekar Gayatri , Bansal Beena , Goyal Ramesh , Joshi Shilpa , Singal Arbinder

Background and aim: Early glycemic control and weight reduction in diabetes has been associated with prevention of progression of β-cell dysfunction and reduction in diabetes-related complications. Digital therapeutics (DTx) platforms can provide evidence-based therapeutic interventions to improve glycemic control using sustainable behavior change. This study aims at assessing the real-world effectiveness of the Fitterfly Diabetes program in improving glycemic control and...

ea0090p103 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Transition from childhood to adult care in type 1 diabetes mellitus: Single-center experience

Yiğit Yalcın Betul , Tercan Ummahan , Yıldız Melek , Hacisahinogullari Hulya , Yenidunya Yalin Gulsah , Gul Nurdan , Selcukbiricik Ozlem Soyluk , Kubat Uzum Ayse , Poyrazooglu Sukran , Bas Firdevs , Karşıdağ Kubilay , Satman Ilhan , Darendeliler Feyza

Introduction: Type 1 diabetes mellitus (T1DM) requires lifelong management, and a well-designed protocol may facilitate transition from child-centered healthcare systems to adult-oriented systems.Aim: We aimed to evaluate sociodemographic data, clinical features and laboratory parameters that may affect the transition period and post-transition process in T1DM patients.Materials and Methods: We retrospectively analyzed 64 patients ...

ea0090p104 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Effects of Diospyros Kaki Derived Exosomes on Beta Cell Homeostasis

Kabataş Bilge , Yildirim Merve , Eren Olcay , Unsal Naz , Eren Simge

Introduction: Exosomes are nanoparticles containing bioactive molecules reflecting individual physiological status, regulating metabolism, and repairing damaged tissues. Exosomes are extracellular vesicles with nano-sized features (30-150 nm) involved in cell-to-cell communication and maintaining homeostasis. The function of exosomes is different according to their cargo and they can contain lipids, proteins and nucleic acids. Exosomes originating from mammalian cells as well ...

ea0090p105 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

New risk score for cardiovascular mortality in frail elderly people with type 2 diabetes

Vasovic Olga

Background: Cardiovascular mortality is the leading cause of death in elderly people with diabetes. Traditional cardiovascular risk factors are not principal predictors for cardiovascular events in frail elderly.Aim: This prospective study examined biomarkers associated with cardiovascular mortality in 253 community dwelling elderly aged 65 to 99 years. Patients were divided into four main groups: GROUP A-Patients with type 2 diabetes and history of MACE...

ea0090p325 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Insulin resistance and hyperglycemia induce mitochondrial dysfunction and a metabolic towards use of gluconeogenic amino acids in epithelial kidney cells

Braga Patricia , Bernardino Raquel , Guerra-Carvalho Barbara , Carrageta David F. , Rodrigues Anabela , Oliveira Pedro F. , Alves Marco

Diabetic nephropathy (DN) and insulin resistance (IR) in kidney cells are considered the main cause of end-stage renal failure. Additionally, hyperglycemia and increased fatty (FA) acids are observed in patients with type 2 diabetes mellitus, where lipid accumulation has been correlated to IR. Nonetheless, the impact of IR in early disease stages is still unclear. Moreover, proximal renal tubular cells have high mitochondrial content where aerobic respiration is their primary ...

ea0090p326 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Effects of a combinatory treatment with semaglutide and a NPY Y2 receptor selective PYY 3-36 analogue in diet-induced obese rats: surpassing bariatric surgery?

Oertel Marie , Theisen Julia , Ecker Katharina , Kohlhaas Michael , Nickel Alexander , Fassnacht Martin , Maack Christioph , Sequeira Vasco , Dischinger Ulrich

Background: Combinatory treatments with analogues of incretins might mimic the beneficial effects of bariatric surgery. We could show in the past that a combinatory treatment with PYY 3-36 and liraglutide leads to a similar body weight loss as Roux-en-Y gastric bypass (RYGB). We hypothesize that a combination of semaglutide and a modified PYY 3-36 analogue with increased selectivity for the neuropeptide Y receptor type 2 (NNC0165-1273) exceeds the weight-reducing effects of ba...

ea0090p327 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

The impact of Diabetes Mellitus in patients with Pulmonary Fibrotic Disease; disease progression and bronchoalveolar lavage evaluation

Tsakalomatis Panagiotis-Nikolaos , Vasarmidi Eirini , Tsitoura Eliza , Bibaki Eleni , Antoniou Katerina , Xekouki Paraskevi

Rationale/Objective: Diabetes Mellitus (DM) and Interstitial lung Disease (ILD) share common pathogenetic pathways involving inflammatory cells and in particular monocytes and macrophages. Diabetic patients are at higher risk of developing pulmonary fibrosis, whereas DM is a major comorbidity in ILD patients. In our study, we analyzed retrospectively patients with ILD and aimed to examine differential characteristics between patients with and without DM, including disease para...

ea0090p328 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

How do diabetes-related ketoacidosis outcomes compare between hospitals? Results from a quality improvement project

Hallum Abigail , Narendran Arjun , Dalzell Joseph , Needs Catherine , George Arun , Narendran Parth , De Parijat , Lubina Solomon Alexandra , Krishnasamy Senthil , Raghavan Rajeev , Working Group Dekode

Background: The appropriate and timely management of diabetes-related ketoacidosis (DKA) has important implications for patient outcomes. Despite the availability of national management guidelines to promote standardised care, we do not know if there are differences in DKA outcomes and complications between hospitals.Aim: To assess for differences in DKA outcomes and treatment complications between hospitals.Methods: This retrospec...

ea0090p329 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

RNA-seq profiling from white adipocyte to brown adipocyte-like cells trans-differentiation of 3T3-L1 by β3-adrenergic stimulation

Jib Yoo Soon , Hong Oak-Kee , Kim Eun-Sook , Kwon Hyuk-Sang

Beige adipocytes can be induced from white adipocytes (WAT) and precursors upon stimulation by cold temperatures and act like brown adipocytes (BAT) to increase energy expenditure. Most in vivo studies examining the mechanisms for the induction of beige/brown adipocytes have focused on subcutaneous white adipose tissue (sWAT) in the mouse. To better understand the development of beige/brown adipocytes from mammalian sWAT, we induced WAT and BAT from 3T3-L1 preadipocyt...

ea0090p330 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Cabergoline counteracts adipose and skeletal muscle lipid accumulation through promoting oxidative pathway: an in vivo and in vitro preclinical study

Negri Mariarosaria , Pivonello Claudia , Amatrudo Feliciana , Patalano Roberta , Monto Tatiana , Paola Provvisiero Donatella , Simeoli Chiara , de Angelis Cristina , Simona Auriemma Renata , Colao Annamaria , Crescenzo Raffaella , Pivonello Rosario

Obesity, characterized by an abnormal body fat accumulation mainly caused by a chronic imbalance between energy intake and expenditure, is a massive public health problem. Targeting excessive fat deposition in adipose tissue and ectopic fat accumulation in skeletal muscle through promoting lipid oxidation pathway may represent a promising strategy to counteract obesity. This study aims at investigating the effects of cabergoline (CAB), a dopamine agonist, on adipose and skelet...

ea0090p331 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Exploration of Clinical Improvements Following Setmelanotide in Patients With Bardet-Biedl Syndrome

Haqq Andrea M. , Chung Wendy , Dollfus Helene , Iqbal Anoop , A. Martos-Moreno Gabriel , Poitou Christine , Yanovski Jack A. , Malhotra Sonali , Miller Paul , Yuan Guojun , Forsythe Elizabeth , Clement Karine , Argente Jesus

Background: In patients with Bardet-Biedl syndrome (BBS), signaling impairments in the melanocortin-4 receptor (MC4R) pathway lead to hyperphagia and severe obesity, which negatively impact quality of life (QOL). We evaluated the impact of setmelanotide, an MC4R agonist, on age-appropriate weight-related parameters, hunger, and QOL in a Phase 3 trial of patients with BBS to further characterize clinical benefit in this patient population.Methods: Patient...

ea0090p332 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Enhanced antibacterial activity of green ZnO NPs against multi-drug resistant bacterial pathogens from diabetic foot ulcer using Aristolochia indica

Kumar Subhash , Prasad Singh Surendra

Introduction: Diabetic foot ulcers (DFU) have developed into a more common complication among people with uncontrolled diabetes, who also have higher morbidity rates and are more prone to polymicrobial infections that spread quickly and cause irreparable tissue damage. The most difficult aspect of treating diabetic foot ulcers (DFU) is the rising prevalence of multi-drug resistant germs, which necessitates the use of a novel antimicrobial agent.Objective...

ea0090p333 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Diabetes Distress among Type 1 Diabetic adolescents in India

Saboo Bharat , Chavda Vipul , Inamdar Aniket , Tewari Ajoy , Hasnani Dhruvi

Introduction: Diabetes distress, a term used to describe negative emotions associated with diabetes, is the key factor responsible for the elevated risk of psychological burden and compromised self-management. The aim of this study is to determine the prevalence of diabetes-related distress among adolescent patients with type 1 diabetes (T1D) and to ascertain various factors associated with it.Materials and methods: In this cross-sectional study, 102 T1D...

ea0090p334 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Usefulness of Intermittent Intersticial Glucose Monitoring in Patients Admitted to The Intensive Care Unit of The Hospital Universitario San Cecilio in Granada

Rodriguez Juarez Raul , del Carmen Andreo-Lopez Maria , Martinez Elena , Garcia Javier , Teresa Cruces Moreno Maria , Jose Lopez Ibarra Pablo

Objective: The carbohydrate metabolism dysfunctions are common in critical ill patients with diabetes or stress hyperglycaemia and the correct management of them has an important prognostic value. Despite its limitations, capillary glucose (CG) was collected more than arterial glucose (gold standard) because of its good correlation. However, the usefulness of intermittent intersticial glucose monitoring (IGM) in keeping blood glucose within target range in critical ill patient...

ea0090p335 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Dapagliflozin Improves Glycemic control and Liver Function with Body Weight Loss as Add-on therapy to Metformin Plus Evogliptin: A 24-week, Randomized, Double-blind, Clinical Trial

Jeong In-Kyung , Mook Choi Kyung , Ah Han Kyung , Kim Kyoung-Ah , kim injoo , jin Han Seung , Wan Lee Byung , Lee Won-Young , Jib Yoo Soon

Background and aims: The efficacy and safety of dapagliflozin as add-on therapy in patients with type 2 diabetes mellitus (T2DM) and inadequate glycemic control with evogliptin and metformin combinations was investigated.Materials and methods: Patients with HbA1c of 7.0% to 10.5% receiving evogliptin 5mg and metformin ≥1000 mg were randomized to receive dapagliflozin 10 mg/day (n=99) or placebo (n=99) for 24 weeks. The primary end...

ea0090p336 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Oral Semaglutide Improves Metabolic Outcomes in Type 2 Diabetes: A Spain-based Study

Casado Carlos , Jair Cardenas Salas Jersy , Miguel Sierra Poyatos Roberto , Montoya Alvarez Teresa , Meneses Gonzalez Diego , Gabriel Ruiz Sanchez Jorge , Luiza Luca Bogdana , Sanchez Lechuga Begona , de los Angeles Velez Romero Maria , Vazquez Martinez Clotilde

Objectives: To evaluate the changes in HbA1c, basal glucose, weight, and lipid profile in patients with type 2 diabetes after starting oral semaglutide.Methods: This study was conducted in Madrid, Fundación Jiménez Díaz, Infanta Elena and General de Villalba hospitals. A total of 75 patients with type 2 diabetes were included. The mean age was 62.0&pm;10.5 years and 60% were men. The mean duration of diabetes was 7.3&pm;6.6 years, and 66.7...

ea0090p337 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

PDE4 Inhibitors Act in The Brain to Ameliorate Metabolic Parameters in Diet-Induced Obesity

da Silva Hellen , Mendonca Duarte Luiza , De Souza Seixas Michele , Antunes Rodrigues Jose , de Paula Francisco , Elias Lucila

Obesity is associated with peripheral and central low grade inflammation characterized by the increase in pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF). Phosphodiesterase 4 (PDE4) modulates the inflammatory responses and its inhibitor can strongly reduce TNF release and inflammation. Additionally, PDE4 knockout mice were shown to be resistant to diet-induced obesity (DIO). The aim of this study was to investigate the role of central and peripheral effec...

ea0090p338 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

High-fat diet causes transgenerational alteration in the expression of Obesity-related genes in mouse seminal vesicles

Rodrigues Beatriz , Pereira Sara C. , Alves Marco , Oliveira Pedro F. , Bernardino Raquel

Obesity incidence is increasing globally at an alarming rate, particularly amongst children and young adults. Male obesity has been linked with a reduction in sperm quality and consequently decreased fertilization rates. Seminal vesicles are considered fundamental for male fertility and though for men’s health. Vesicle seminal secretion contributes to a significant volume of seminal fluid, being extremely important for semen coagulation and sperm motility. Recent studies ...

ea0090p339 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Therapy of overweight and obesity resistant to behavioral treatment in the adult population with metabolic comorbidities. A network meta-analysis

Samperi Irene , Persichetti Agnese , Attanasio Roberto , Busetto Luca , Cinquini Michela , Paoletta Agostino , Papini Enrico , Novizio Roberto , Scoppola Alessandro , Vettor Roberto , Chianelli Marco

Background: Overweight and obesity are an increasing concern for public health worldwide. Obesity is a chronic, progressive and relapsing disease associated with the development of several comorbidities which may improve after weight loss. The first step in the management of weight excess includes life-style modifications but, in the long-term, obesity is frequently resistant to life-style changes only. Surgical procedures and medical treatments have, therefore, been developed...

ea0090p340 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

The Effect of Foot Care Protocol Applied to Individuals with Type 2 Diabetes on Foot Health Problems and Foot Care Behaviors

Kahraman Aslı , Kir Bicer Emine

Aim: The research was conducted as a randomized controlled experimental study to determine the foot health status of individuals with type 2 diabetes and the factors affecting them, to use a protocol to protect and improve foot health for individuals with diabetes, and to determine the effects of this protocol on foot health problems (regarding dermatology, orthopedics, circulation, sensory, footwear and self-care skills), foot health knowledge and foot care behaviors.<p c...

ea0090p341 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Prevalence and Impact of Diabetes Mellitus in Adult Tuberculosis Patients;A Cross-Sectional Study

Xhardo Hysenbelli Elona , Hysenbelli Bledar , Ylli Dorina , Smaja Genta

Background: Both diabetes mellitus (DM) and tuberculosis (TB) are major public health problems and among the leading causes of morbidity and mortality worldwide. The TB-DM coexistence is known to complicate TB care, control and prevention. Globally, 10.4 million TB cases exists, of them 10 % are linked to DM. People with DM are at four to five times higher risk of getting infected with tuberculosis and evidence show poor TB treatment outcomes. This study purposed to evaluate t...

ea0090p342 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Characteristics of components of metabolic syndrome in patients with diabetic kidney disease depending on the phenotype of latent autoimmune diabetes in adults

Tsaryk Iryna , Pashkovska Nataliia

Background: Metabolic syndrome is a cluster of conditions (abdominal obesity, atherogenic dyslipidemia, hypertension, insulin resistance with or without glucose intolerance) that occur together, increasing risk of cardiovascular diseases.The objective: Of the study was to determine components of metabolic syndrome in patients with diabetic kidney disease (DKD) depending on the phenotype of LADA.Methods: 42 patients with LADA (19 pa...

ea0090p343 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Prevalence of mutations in cublin-megalin receptor genes in Diabetis Mellitus: Subset analysis of an Indian NGS (Next Generation Sequencing) study

Bangaraiahgari Ramesh , Bhargav Panchangam Ramakanth , Kumar N Udaya , Bangaraiahgari Rajesh , Mayilvaganan Sabaretnam , Bangaraiahgari Chakrapani

Background: Diabetes mellitus (DM) is the commonest endocrinopathy, Worldwide. Amongst the protean complex genetic variations, cubulin gene and megalin gene mutations in diabetes are important in dictating genotype-phenotypic correlations and natural clinical course of diabetes. The genetic studies in this area are especially very sparse from Indian sub-continent. In this context, we analyzed the prevalence of cubulin (CBN) and megalin (LRP2) gene mutations, as part of NGS (Ne...

ea0090p344 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Changes in Glycemic Risk Index (GRI) and its Association with other Continuous Glucose Monitoring (CGM) Metrics after Automated Insulin Delivery System Initiation in Adults with Type 1 Diabetes

Akturk Halis , Karakus Kagan , Klonoff David , Shah Viral

Objective: To evaluate the GRI and its association with other CGM metrics after initiation of automated insulin delivery (AID) system in adults with type 1 diabetes (awT1D).Methods: Up to 90 days of CGM data before and after initiation of an AID system from 185 awT1D were collected. GRI with hypoglycemia and hyperglycemia components and other CGM metrics were calculated using cgmanalysis R software and analyzed for 24-hour, nighttime, and daytime. GRI va...

ea0090p345 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Vitamin D deficiency and gestational diabetes

Jude Edward , Sugathan Navin , Mathew Susan

Introduction: Vitamin D deficiency is known to cause adverse outcomes in pregnancy and has shown to have an association with Gestational Diabetes Mellitus (GDM)Aim: To evaluate the relationship between GDM and Vitamin DMaterials and Methods: In a retrospective study we explored the Vitamin D levels (Sufficient >50nmol/l - G1, Insufficient 25-50nmol/l - G2, Deficient <25nmol/l - G3), GTT results, diabetes status and pregnanc...

ea0090p346 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Sex-driven factors associated with anxiety and depression in Type 1 Diabetes Mellitus (T1DM) and Latent Autoimmune Diabetes in Adults (LADA)

Saudelli Enrico , Moscatiello Simona , Baldari Michele , Bongiorno Claudio , Zucchini Stefano , Maltoni Giulio , Agostini Alessandro , Ribichini Danilo , Bruco Alessia , Lo Preiato Valentina , Laffi Gilberto , Pagotto Uberto , Di Dalmazi Guido

Aim: To analyze the prevalence of anxiety and depression in a large cohort of adults affected by autoimmune diabetes and to identify the associated factors, stratifying them according to sex.Methods: We administered to 553 patients with autoimmune diabetes the questionnaires: Hospital Anxiety and Depression Scale (HADS), Diabetes Distress Scale, Diabetes-related Quality of Life and Diabetes Treatment Satisfaction Questionnaire. We excluded 119 patients w...

ea0090p348 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Bexagliflozin in Patients with Type 2 Diabetes: Scoping Review of the Published Randomised Control Trials

Redkar Vivek , Redkar Sagar , Redkar Supriya , Manohar Manohar , Inamdar Aniket , Jumani Deepak , Kulkarni SV , Das Shreya , Das Rajarshee , Arora Muskan

Introduction: US Food and Drug Administration (FDA) has recently approved bexagliflozin, a new SGLT2 inhibitor. We examined the outcomes and metabolic effects of Bexagliflozin across the published Randomised Controlled Trials (RCCTs)Methods: A comprehensive literature search was done to extract publications from Medline-PubMed and Cochrane library, since inception till January 20, 2023, then screened and reviewed by two independent reviewers. Data includ...

ea0090p349 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Non Interventional Weight Changes are Associated with Alterations in Lipid Profile and in Trigycerides to Hdl-Cholesterol Ratio

Weinstein Shiri , Maor Elad , Kaplan Alon , Leibowitz Avshalom , Grossman Ehud , Shlomai Gadi

Background and aims: Obesity is associated with dyslipidemia through insulin resistance and adipokines secretion, and weight loss can improve obese patients’ lipid profile. Here we aimed to assess whether non interventional weight changes are associated with alterations in the lipid profile, particularly the triglycerides (TG) to high density lipoprotein (HDL) cholesterol ratio (TG/HDL) which is an emerging marker for insulin resistance, the metabolic syndrome and an elev...

ea0090p350 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Loss of visceral adipose tissue may lead to a shortened aortomesenteric distance in congenital generalized lipodystrophy

Cağrı Unal Mehmet , Uncuoğlu Furkan , Gungor Semiz Gokcen , Emin Arayici Mehmet , Yener Serkan , Altay Canan , Akıncı Barış

Introduction: Superior mesenteric artery (SMA) syndrome is a rare cause of abdominal pain due to proximal intestinal obstruction which is characterized by compression of the third portion of the duodenum secondary to the narrowing of the space between the superior mesenteric artery and aorta. The development of the SMA syndrome is primarily attributed to the loss of the intervening mesenteric fat. Lipodystrophy is a rare clinical syndrome characterized by the loss of adipose t...

ea0090p351 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

High-fat diet promotes 3’mt-tiRNA-Met epididymosome enrichment which correlates to lower spermatozoa mitochondrial translation

Pereira Sara C. , Freire-Brito Lais , Guerra-Carvalho Barbara , Carrageta David F. , Bernardino Raquel , Crisostomo Luis , Terzo Simona , Monteiro Mariana P. , Oliveira Pedro F. , Allegra Mario , Alves Marco

Metabolic and endocrine dysregulation induced by high-fat diet (HFD) can lead to decreased male fertility potential and have a negative impact on the offspring’s metabolic health. Small non-coding RNAs (sncRNAs) were proposed as being potential mediators of metabolic queues across transgenerational inheritance. During development and epidydimal transit, spermatozoa become enriched with tRNA-derived stress-induced RNAs (tiRNAs). This sncRNAs class appears to be particularl...

ea0090p352 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Obesity in pediatric patients with Bardet - Biedl Syndrome – diagnostic hint and therapeutic challenge

Nowak Maria , Ciołek Michał , Szczepańska Maria , Tomaszewska Agnieszka , Hildebrandt Friedhelm , Zachurzok Agnieszka

Introduction: Bardet-Biedl Syndrome (BBS) is an autosomal recessive disease and one of the most common causes of syndromic obesity. An excessive weight usually appears at an early age and affects almost 90% of patients. Mutations in BBS genes have been found to disrupt the function of the cilia, leading to disturbances of transduction satiety and hunger signals in hypothalamus and increased adipogenesis in the fat tissue.Methods: We present a case series...

ea0090p353 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Real-life outcomes of semaglutide therapy for weight loss

Tzoulis Ploutarchos

Background: Obesity, a chronic relapsing disease, has become a global public health challenge. Semaglutide, a weekly glucagon-like peptide-1 (GLP-1) agonist which has shown unprecedentedly high efficacy in randomised controlled trials, was recently approved in Europe for weight loss. There is paucity of real-life data about its effectiveness and safety for weight management.Methods: Our aim was to evaluate the changes in weight and metab...

ea0090p354 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Chronic inflammation linked to obesity has a negative impact on serum glycated albumin levels, but not glycated hemoglobin levels

Kumar Subhash , Prasad Singh Surendra

Background: Glycated albumin (GA) and glycated haemoglobin (HbA1c) measurements have been used to track the long-term glycemic management of diabetic patients. Other than glycemia, there are known influences on both glycated proteins. In obese, non-diabetic children, GA levels have been found to be low, while in adult diabetic patients, GA levels have been found to be adversely correlated with body mass index (BMI). The causes of the link between obesity and GA are still unkno...

ea0090p355 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

What role does the Very Low-Calorie Ketogenic Diet (VLCKD) in obesity-related kidney complications?

Verde Ludovica , Docimo Annamaria , Chirico Giovanni , Tecce Nicola , Colao Annamaria , Barrea Luigi , Muscogiuri Giovanna

Background: Obesity can damage kidney via directly, through the production of pro-inflammatory adipocytokines, and indirectly due to systemic complications. Several strategies are available for weight loss (lifestyle, anti-obesity drugs and surgery therapy), but there are no guidelines to manage subjects with obesity and chronic kidney disease. Very low-calorie ketogenic diet (VLCKD) is an increasingly used tool for weight loss in subjects with obesity. Thus, we aimed to inves...

ea0090p356 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Managing stigma of Adolescents Diabetes in developing nations

Pal S , Roy T

Issues: Adolescent diabetes social stigma in India. Such diabetics needs proper guidance/information/treatment-counselling outlets. This is burning issue in developing-nations like India. Hence we all need to unite & form a comprehensive diabetes care & counselling policy plan at ECE conference. Treatment options must be suitable for developing-nations considering cost of Rx. Incorporating NGO’s in such efforts is very effective.Our Project ...

ea0090p357 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Assessment of Western dietary patterns in Georgian population with prediabetes

Gvajaia Nino , Kvinikadze Nana , Pestvenidze Elene , Tkeshelashvili Mariam

A Western dietary pattern, characterized by high consumption of red and processed meat, soft drinks, refined grains, fats and sweets, has frequently been associated with an increased disease risk. However, the distinct association between the nutritional habits and prediabetes has only been scarcely investigated in Western populations. The aim of this study is to underline the relationship and suggest the possible causality between the two. We conducted descriptive survey and ...

ea0090p358 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Vitamin B12, lipid profile and peripheral diabetic neuropathy in type 2 diabetic patients on Metformin: any association?

Adel Meriem , Jemel Manel , Gharbi Radhouen , Kardi Asma , Khalfa Brahim , Kandara Hajer , Kammoun Ines , Mahjoub Rahma , Talbi Emna

Introduction: Several studies have evaluated the prevalence and impact of metformin induced vitamin B12 deficiency in type 2 diabetes patients. On the other hand, low vit B12 was associated with adverse lipid profile.Aim: To evaluate the relationship between vitamin B12 deficiency and the lipid profile in patients with neuropathy.Patients and methods: A cross-sectional study included 123 type 2 diabetic patients treated with metfor...

ea0090p359 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Puberty and staturoponderal development in type 1 diabetec patients

Ben Salem Dorra , Lajili Olfa , Mohsen Selma , Ben Jemaa Hana , Jemai Chaima , Ben Mami Feika

Introduction: Type 1 diabetes affects the puberty and staturopondral development of young diabetics.Objective: Assess pubertal status in young DT1 patients and determine factors influencing pubertal development.Materiel and method: Retrospective study involving 89 type 1 diabetics aged ≤ 18 years hospitalized in the department C of the National Institute of Nutrition of Tunis between January 2022 and October 2022.<p class...

ea0090p360 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Consensus Towards Reassessing Gliclazide for the Place in Therapy Based on Novel Cluster Classification of Diabetes

Sethi Bipin , A G Unnikrishnan , Ayyagari Usha , Narayanan Prem , Acharya Raviraj , Balachandran Karthik , Reena Adlyne , Lathia Tejal

Introduction: A novel classification of adult onset DM into five subgroups: Severe Autoimmune Diabetes (SAID); Severe Insulin-Deficient Diabetes (SIDD); Severe Insulin-Resistant Diabetes (SIRD); Mild Obesity-Related Diabetes (MOD); and Mild Age-Related Diabetes (MARD) has been postulated. We aim to formulate a consensus statement towards reassessing gliclazide use based on cluster classification of diabetes mellitusMethods: A virtual collaborative educat...

ea0090p361 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Urinary tract infections in patients with diabetes mellitus

Khalaf Rahma , Hadj Ali Zohra , Htira Yosra , Imene Hedfi , Jemai Chaima , Ben Mami Feika

Background and Aim: Patients with diabetes mellitus(DM) are at increased risk of infections, with the urinary tract being the most frequent infection site. High rates of antibiotic prescription, including broad-spectrum antibiotics, for urinary tract infection (UTI) in these patients may further induce the development of antibiotic-resistant urinary pathogens. The aim of our study is to determine the epidemiology of UTI and resistance patterns of bacterial isolates in patients...

ea0090p362 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Estimation of “Physical Activity Level Equivalence” of Energy Expenditure in Adults with Severe and Complicated Obesity

McGarel Sian , O'Connor Sadhbh , McGrath Aisling , Finucane Francis

Obesity is often framed as a consequence of inadequate physical activity, and patients with severe obesity sometimes attribute their weight gain to immobility and reduced exercise. We sought to compare Total Daily Energy Expenditure (TDEE) in adults with severe obesity to what their predicted TDEE would be at their Ideal Body Weight (IBW). We conducted a cross-sectional analysis of the Croí CLANN prospective cohort study of patients with severe obesity attending our regio...

ea0090p363 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Bulimia Investigatory Test of Edinburgh (BITE) use in an endocrinology outpatient clinic

Alexandra Zapata Maldonado Gabriela , Gonzalez-Villa Maria , Luis Talledo Madrid Pedro , Ines Simbana Aragon Gabriela , Alcantara-Aragon Valeria

Objectives: To evaluate the prevalence of eating disorders (ED) at an Endocrinology outpatient clinic (EOC); with the use of Bulimia Investigatory Test of Edinburgh (BITE).Methods: Descriptive analysis of clinical characteristics and BITE scores from patients with suspicion of ED at a first appointment in an EOC with an average of 128 new patients/year. Data was collected from January-2021 to December-2022. The main suspicion criteria were: self-reported...

ea0090p364 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Metformin Ameliorates Fatty Liver Disease in A High-Fat Diet-Induced Obese FVB/N Mouse Model

Lozano de la Haba Samanta , Herman-Sanchez Natalia , Ojeda Perez Betsaida , Garcia-Estrada Antonio , Sarmento-Cabral Andre , M Luque Raul , Gahete Manuel D.

Objectives: Previous studies have shown that metformin can reduce high-fat diet (HFD)-induced body weight gain and fat accumulation in the liver. However, the results obtained in animal models regarding the implication of metformin in the modulation of other whole-body and tissue-specific parameters, are controversial or need to be further explored. Consequently, we aimed to explore the capacity of metformin in modulating glucose/insulin metabolism, liver function, adiposity, ...

ea0090p365 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Metabolic abnormalities in adult population with spinal muscular atrophy

Rakusa Matej , Firbas Dejan , Rudolf Tjasa , Goricar Katja , Janez Andrej , Jensterle Mojca

Background: Spinal muscular atrophy (SMA) is hereditary, degenerative, neuro-muscular disease of lower motor neurone that leads to muscle weakness and atrophy. Several metabolic disturbances such as impaired glucose tolerance (IGT), insulin resistance (IR), hypoglycaemia and dyslipidaemia can be present. Most studies were done in children, with more severe forms of SMA. We aimed to assess body composition, IR, glucose and lipid metabolism in adult patients with SMA type 2 and ...

ea0090p366 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Assessing Foundation Doctors knowledge on the use of Sodium-glucose cotransporter 2 (SGLT2) Inhibitors: A Quality Improvement Project

Haddad Aiman , Sharma Angelica , Lee Tse Tsz , Taufik Bara , Seetho Ian

Introduction: Sodium Glucose Co-transporter 2 inhibitors (SGLT2i) are a novel class of glucose-lowering therapies that have demonstrated prognostic benefit in the management diabetes, heart failure and renal impairment. National Institute for Health and Clinical Excellence (NICE) guidance recommends offering SGLT2i, in addition to metformin, first-line in individuals with type 2 diabetes (T2D) and chronic heart failure/ established atherosclerotic cardiovascular disease. Howev...

ea0090p367 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Diabetic keto-acidosis secondary to sodium glucose co-transporter inhibitors: single-centre experience

Nozdrin Mikhail , Selyanina Maria , elshowaya suhier , Ahmed Ghada , Rzeszowski Blazej , Abreu Rafael , Mihalikova Simona , Mlawa Gideon

Background: SGLT-2 inhibitors (SGLT-2i) are used in treatment of type 2 diabetes mellitus (T2DM) through increasing urinary glucose secretion. Cases of euglycemic and hyperglycaemic diabetic ketoacidosis (DKA) have been reported in literature in patients using SGLT-2i. Increased glucose urinary excretion promoted by SGLT2i, decreases the production of insulin. In turn, lipolysis and ketone production increase predisposing the patient to developing DKA. It is hypothesised that ...

ea0090p368 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

LMF1-associated Chylomicronemia Syndrome

Yacobi Bach Michal , Serebro Merav , Baris Feldman Hagit , Greenman Yona

Introduction: Familial Chylomicronemia-FC syndrome is characterized by severely elevated triglyceride levels, i.e., levels of TG above 1000 mg/dl. Monogenic etiology is associated with a small but a significant fraction of Familial Chylomicronemia (FC) Syndrome cases, which is mainly attributed to a few genes, that are involved in Lipoprotein Lipase activity (LPL / LMF1 / APOC2 / GPIHBP1 / APOA5). Bi-allelic variants in these genes cause this rare Autosomal Recessive ...

ea0090p369 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Impact of exenatide on weight loss and eating behavior in adults with craniopharyngioma-related obesity: the Cranioexe randomized placebo-controlled trial

Gatta-Cherifi Blandine , Mohammedi Kamel , Cariou Tanguy , Poitou-Bernert Christine , Touraine Philippe , Raverot Gerald , Brue Thierry , Chanson Philippe , Illouz Frederic , Solange Grunenwald , Chabre Olivier , Sonnet Emmanuel , Cuny Thomas , Bertherat Jerome , Czernichow Sebastien , Frison Eric , Tabarin Antoine

Background: Hyperphagia leading to craniopharyngioma-related obesity (CRO) is a common and serious sequel of treatments of craniopharyngiomas. The few therapeutic approaches that have been tested until now for the control of eating behaviour and weight have poor efficacy. Glucagon-like peptide-1 (GLP-1) analogues might be an option. Methods: This multicentre, randomised, double-blind superiority trial was conducted in France. Adults with CRO (BMI > 3...

ea0090p370 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Characteristics of carbohydrate metabolism and insulin resistance in patients with chronic pyelonephritis depending on the phenotype of latent autoimmune diabetes in adults

Pashkovska Nataliia , Tsaryk Iryna

Background: Chronic pyelonephritis (CP) is a common kidney infection complication in patients with diabetes mellitus and one of the main reasons of chronic kidney disease in diabetic patients.The objective: Of the study was to determine the features of the carbohydrate metabolism and insulin resistance in patients with CP depending on the phenotype of latent autoimmune diabetes in adults (LADA).Methods: 28 patients with LADA and CP...

ea0090p371 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Prevalence and Predictive Factors of Painful Diabetic Peripheral Neuropathy in The Department of Endocrinology and Metabolic Diseases of The Uhc Ibn Rochd In Casablanca: About 623 cases

Gueddari Amine , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Peripheral neuropathy is one of the most common complications of diabetes. Its prevalence is very different according to the studies ranging from 8 to almost 60%. The symptomatology can be very polymorphic. Its painful form, painful diabetic neuropathy (PDN), is the most common cause of peripheral neuropathy.Objective of the study: Our objective was to determine the prevalence and factors associated with PDN.Material ...

ea0090p372 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Diabetic ketoacidosis as first presentation of diabetes mellitus in a subject with Friedreich’ ataxia. A case report and review of literature

Kermaj Marjeta , Zeneli Olta , Hoxha Violeta , Poshi Klodiana , Ylli Dorina , Ylli Agron

Introduction: Friedreich ataxia (FA) is a multisystem autosomal recessive disease with progressive clinical course involving the neuromuscular and endocrine system. Individuals with FA have an increased risk of developing diabetes. In FA-associated diabetes, both insulin deficiency and insulin resistance have been reported. We present a case with FA, presented with diabetic ketoacidosis (DKA) as the first presentation of diabetes mellitus.Case Presentati...

ea0090p373 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Glycemic control in Type 1 Diabetes patients using multiple daily insulin injections (MDII) vs continuous subcutaneous insulin infusion (CSII)

Tsitsimpis Anastasios , Cherolidi Helen , Kalogeris Nikolaos , Spanou Loukia , Mouslech Tzant , Somali Maria , Georgiopoulos Georgios , Vryonidou Andromachi

Objective: Glycemic control of patients with type 1 diabetes is mainly based on insulin administration. The ongoing technological developments in continuous glucose monitoring (CGM) and continuous subcutaneous insulin infusion (CSII) provide new treatment strategies, with better glycemic control. This study assessed the clinical impact of two treatment strategies in adults with type 1 diabetes (T1D): multiple daily insulin injections (MDII) vs continuous subcutaneous insulin i...

ea0090p374 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

The Effect of Diabetes Mellitus on the Outcome of Sars-Cov-2 Infection

Moschopoulos Theodoros , Athanassiou Panagiotis , Athanasiou Ifigenia Kostoglou

Introduction: Infection from the severe respiratory distress syndrome coronavirus 2 (SARS-CoV-2) virus may present as mild disease or as severe disease with high mortality. Although the majority of patients infected by the virus have a good prognosis, chronic diseases, such as diabetes mellitus (DM), especially in older adults may be a risk factor for a worse outcome. DM is a frequent comorbidity in patients with COVID-19. Aim: The aim of the present wor...

ea0090p375 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Reduction in Diabetes Distress and Improvement in Sleep Quality correlating with Better Glycemic Control Within 90 Days on Fitterfly Diabetes Program

Lathia Tejal , Verma Neha , Gupta Nishul , Rajawat Priyadarshini , Srivastava Ankita , Verma Ritika , Chhaya Gaurav , Ghaisas Nitin , Samar Ila , Agarwal Bharat , Singal Arbinder

Background: Managing the relentless requirements of diabetes management can lead to an increase in distress among people with diabetes. There is a need for feasibility studies to understand the effectiveness of multi-disciplinary care delivered using digital therapeutics interventions to provide effective glycemic control along with improved overall well-being of individuals. The study aims to evaluate the feasibility and effectiveness of the Fitterfly diabetes program to impr...

ea0090p376 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Transition to adult care in type 1 diabetes. A single center retrospective study

Bruco Alessia , Moscatiello Simona , Maltoni Giulio , Zucchini Stefano , Malaguti Anna , Saudelli Enrico , Pagotto Uberto , Di Dalmazi Guido

Background: Moving from childhood to adulthood is a challenging process for individuals with type 1 diabetes (T1D), transition has been defined as the planned movement from pediatric to adult department.Aim: To assess glucometabolic control, prevalence of autoimmune disorders, and use of glucose sensors in patients with type 1 diabetes after transition to adult care.Methods: We retrospectively evaluated HbA1c, prevalence of patient...

ea0090p377 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

“Skewing of Antimony Mediated Therapy for an Optimal Insulin Secretion During Visceral Leishmaniasis

Sinha Sukrat

Objective: Visceral Leishmaniasis is a macrophage associated disorder for the treatment of which antimony based drug like Sodium Antimony Gluconate has been the first choice in the recent past. About 5 percent of the patients may develop insulin dependent diabetes mellitus. It appears to have a direct action on pancreatic beta cells, resulting in initial insulin release followed by impaired insulin secretion. Within this context we looked into alternate therapies of treatment ...

ea0090p598 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Impact of Setmelanotide Treatment on Weight- and Body Composition–Related Outcomes in Pediatric and Adult Patients With Hypothalamic Obesity

Miller Jennifer , Shoemaker Ashley H. , Jennifer Abuzzahab M. , Gottschalk Michael , Yuan Guojun , Malhotra Sonali , Scimia Cecilia , Roth Christian L.

Background: Hypothalamic obesity (HO) is an acquired form of severe obesity that can occur following surgical resection of or radiotherapy for brain tumors and is often unresponsive to lifestyle modifications or traditional obesity pharmacotherapies. Here, we report weight- and body composition–related findings from a Phase 2 trial of setmelanotide, a melanocortin-4 receptor agonist, in patients with HO.Methods: A Phase 2, open-label, 16-week trial ...

ea0090p599 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

The new anthropometric indices and atherogenic indices are correlated with glucose status in women with PCOS

Nowak Justyna , Jabczyk Marzena , Jagielski Paweł , Hudzik Bartosz , Kulik-Kupka Karolina , Zubelewicz-Szkodzińska Barbara

Introduction: Polycystic ovary syndrome is complex endocrine disorders, characterized by ovulatory dysfunction, hyperandrogenism and polycystic ovarian morphology. Those are lipid abnormalities, hyperinsulinemia, insulin resistance, impaired glucose metabolism, type 2 diabetes mellitus, metabolic syndrome, hyperandrogenism, oxidative stress and infertility. The visceral adiposity index (VAI) is a reliable marker of adipose tissue abnormalities in women with PCOS. A body shape ...

ea0090p600 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Mitochondrial fitness in mouse Leydig cells is imbalanced by liraglutide upon glucose stimuli

Lopes Bruno , Braga Patricia , Oliveira Pedro F. , Alves Marco , Bernardino Raquel

Metabolic diseases represent a threatening worldwide epidemic that affects the entire body. It is known that metabolic diseases, namely diabetes, and obesity affect spermatogenesis via suppressing testosterone synthesis, inducing oxidative stress and other changes that lead to decreased male fertility. Glucagon-like peptide 1 (GLP1) receptor agonists, like liraglutide, are pharmacological agents recommended to normalize glucose levels in patients with type 2 diabetes mellitus....

ea0090p601 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Development of Exogenous Insulin Antibody Syndrome in a Patient with Type 1 Diabetes Mellitus Using Insulin Analogues

Durmaz Buket , Berivan Butun Tuana , Sakar Kenan , Akbaba Gulhan , Cinar Nese

Introduction: Insulin antibodies, developed in patients treated with exogenous insulin, might affect glycemic control due to their tendency to bind and/or release insulin in an unpredictable fashion. It is reported to be caused by immunoglobulin G-derived insulin antibodies. Insulin antibodies induced by exogenous insulin in diabetic patients is associated with hypersensitivity reactions, glycemic variability mainly with insulin resistance/ hyperglycemia or hypoglycemia. We re...

ea0090p602 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Effect of Origanum vulgare L. essential oil on insulin-induced PI3K/Akt signaling and glucose uptake in human adipocytes treated with palmitic acid

Cerda Alexis , Yuri Gabriela , Villagran Isidora , Muller Andrea , Foerster Claudia , Ormazabal Paulina

Background: Obesity is strongly associated with insulin resistance (IR). IR at the molecular level may be defined as a diminished activation of PI3K/Akt signaling and its related molecules (IRS-1/Akt/AS160) as well as reduced glucose uptake. Subjects with obesity have elevated plasma levels of saturated fatty acids, such as palmitic acid (PA), which triggers insulin signaling disruption in vivo and in vitro. Oregano (Origanum vulgare L.) is a plant u...

ea0090p603 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Strategic Designs to identify the best housekeeping genes for the characterization of biomarkers in adipose tissue of patients with obesity and cancer

Perez Gomez Jesus , Porcel-Pastrana Francisco , de la Luz Borrero Marina , Gahete Manuel D. , Guzman Rocio , Malagon Maria , Luque Raul M.

Obesity (OB) is caused by an energy imbalance that finally leads to adipose tissue dysfunction, and the appearance of multiple comorbidities, such as certain cancer types, including prostate cancer (PCa), which is one of the leading causes of cancer-related death in men population worldwide. In this context, periprostatic adipose tissue (PPAT) has recently gained increased attention as a key regulator of the pathophysiological relationship between OB and PCa. However, it has b...

ea0090p604 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Time In Range and Triglyceride/Glucose Index In Type 2 Diabetes with Mafld

Ragozzino Giovanni , Martina Madonna Igea , Maria Venere Cristiano Nadia , Mattera Edi

Background and Aims: The metabolic-associated fatty liver disease (MAFLD) is a fatty liver accumulation with metabolic dysfunction (diabetes, overweight/obese, insulin-resistance), a definition more practical for identifying patients with fatty liver disease with high risk of disease progression. The triglyceride-glucose (TyG) index is a marker of insulin resistance. Long-term fasting plasma glucose (FPG) variability is associated with fatty liver content (FLC). Continuous glu...

ea0090p605 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

A new referral pathway to the multidisciplinary team for inpatients with diabetic foot pathology

Brazell Madeline , Nahaboo Solim Muzammil , Rios Turek Natalia , Ashwell Simon

Background: In any given week, 2.5% of diabetic patients have a foot ulcer. In the United Kingdom (UK), there are 7000 lower limb amputations in people with diabetes every year and the annual NHS expenditure on diabetic foot-related healthcare amounts to £1 billion. As per the National Institute for Health and Care Excellence guidelines in the UK, a person with diabetes needs to be referred to an MDT within 24 h of finding a foot ulcer. The National Diabetes Footcare Audi...

ea0090p606 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Characteristics of patients admitted to the hospital with diabetes and frailty: preliminary data of an audit in a UK teaching hospital

Melson Eka , Fazil Mohamed , Davitadze Meri , Lwin Hnin , Higgins Kath , Gallagher Alison

Introduction: Older age and diabetes are both risk factors for frailty. Functional decline and disability in older, frail adults with diabetes results in an increased susceptibility to falls and hospital admission. Hypoglycaemia is common and more likely to result in hospital admission in older adults with diabetes and frailty. An HbA1c of below 7% (53 mmol/mol) is likely to represent overtreatment of hyperglycaemia. JBDS has recommended a review of HbA1c...

ea0090p607 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

SIMBA for Students – teaching endocrinology to pre-clinical medical and pharmacy students through online simulation- a pilot study

Rezai Fatema , Allison Isabel , Swaminathan Aditya , Ogiliev Tamzin , Sheikh Haaziq , Morgan Georgia , Zhou Dengyi , Sheikh Jameela , Yip Alice , and CoMICs Team SIMBA , Kempegowda Punith

Introduction: Simulation via Instant Messaging – Birmingham Advance (SIMBA) for Students is an online education model used to teach endocrine topics to pre-clinical medical and pharmacy students using simulated clinical cases delivered through WhatsApp and Zoom. In this study, we investigated the efficacy and acceptability of SIMBA for students compared to traditional small-group teaching (SGT).Methods: These SIMBA sessions were conducted from 2020 ...

ea0090p608 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Intestinimonas butyriciproducens improves glucose metabolism in subjects with obesity and prediabetes: preliminary data from a randomized controlled trial

Antoniotti Valentina , Caputo Marina , TIni Sabrina , Antonioli Alessandro , Daffara Tommaso , De Marchi Silvia , Bona Elisa , Amoruso Angela , Pane Marco , Gul Sahin , Aimaretti Gianluca , Seegers Jos , Prodam Flavia

As the prevalence of type 2 Diabetes Mellitus (T2D) is constantly increasing and the current prevention is not enough, new effective strategies are necessary, in particular in high-risk individuals. Therapeutic microbiology is one of further proposed targets, and, in particular, butyrate-producing bacteria can improve metabolic parameters in obese patients. Our study aims to evaluate the effect of Intestinimonas butyriciproducens as a preventive therapy for T2D in pre...

ea0090p609 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Comparing performance of healthcare professionals from different training grades in SIMBA simulation-based training sessions

Zhou Dengyi , Pallathoor Balakrishnan Harshin , Warmington Emily , Elhariry Maiar , Ali Anisah , Ogiliev Tamzin , Malhotra Kashish , Soran Vina , Sakthivel Pavithra , Synn Cuen Pan Carina , and CoMICs Team SIMBA , Kempegowda Punith

Introduction: Simulation via Instant Messaging – Birmingham Advance (SIMBA) is a simulation-based training model shown to have increased clinicians’ confidence in managing cases in diabetes and endocrinology, as well as sustained clinical knowledge.1 Traditional simulation models have typically focussed on a specific group of healthcare professionals. We evaluated if there is a difference in performance between different training groups during SIMBA.<p...

ea0090p610 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

A Case Report: Rapidly Onset Fournier’S Gangrene In Empagliflozin Treatment for Type 2 Diabetes

Avci Melek , Sakar Kenan , Cinar Nese , Akbaba Gulhan

Introduction: Sodium/glucose co-transporter 2 (SGLT2) inhibitors are a relatively new group of antihyperglycaemic medications for type 2 diabetes mellitus (T2DM). Euglycemic diabetic ketoacidosis (EDKA) and Fournier’s gangrene (FG) are uncommon advers effects of SGLT2 inhibitors. We report a case of a 52-year-old man who developed FG and EDKA after starting the SGLT2 inhibitor empagliflozin.Case Presentation: A-52 years old male patient attended to ...

ea0090p611 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Gaucher Disease Type 3c: A Rare Metabolic Disease Diagnosed In Adulthood

Tuğce Şah Unal Fatma , Demir Ozgur

Background: Gaucher disease (GD) is the most prevalent lysosomal disorder caused by GBA mutations and abnormal glucocerebrosidase function, leading to glucocerebroside accumulation mainly in the liver, spleen, bone marrow, lungs, and occasionally in the central nervous system. Gaucher disease type 3c (GD3c) is a rare subtype of the subacute/chronic neuronopathic GD3, caused by homozygosity for the GBA p. Asp448His (D409H) mutation. Case...

ea0090p612 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Obesity-Associated Hepatic Steatosis, Somatotropic Axis Impairment and Ferritin Levels are Strong Predictors of COVID–19 Severity

Masi Davide , Gangitano Elena , Marino Luca , Criniti Anna , Ballesio Laura , Anzuini Antonella , Angeloni Antonio , Gnessi Lucio , Gandini Orietta , Lubrano Carla

Purpose: From a clinical perspective, the full spectrum of Sars–CoV–2–infected patients has not yet been defined. This study aimed to evaluate whether liver density on computed tomography (CT) scan and serum insulin-like growth factor 1 (IGF1) values can explain the clinical variability of COVID–19 cases.Methods: We performed a retrospective study including SARS–CoV–2–infected patients hospitalized from March 2020 to Ma...

ea0090p613 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Long-term Body Composition in Patients With POMC or LEPR Deficiency Obesity Following Setmelanotide

Clement Karine , Wabitsch Martin , van den Akker Erica , Argente Jesus , Navarria Andrea , Srinivasan Madhura , Yuan Guojun , Malhotra Sonali , Kuhnen Peter

Objective: Ideally, treatment strategies designed to reduce weight or body mass index in patients with obesity should reduce fat mass while preserving lean mass because reduced lean mass can negatively impact overall health and energy expenditure, thus favoring weight regain. In Phase 3 trials, 1 year of treatment with the melanocortin-4 receptor agonist setmelanotide led to weight reduction in patients with obesity due to biallelic variants in the genes encoding proopiomelano...

ea0090p614 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Serum Vitamin B12 Levels and Diabetic Retinopathy in Type 2 Diabetes

Adel Meriem , Jemel Manel , Gharbi Radhouen , Grassa Anis , Chaari Yasmine , Kandara Hajer , Kammoun Ines , Mahjoub Rahma , Talbi Emna

Introduction: Diabetic retinopathy (DR) is a serious microvascular complication of type 2 diabetes and the leading cause of blindness worldwide. Several studies have reported the association between metformine-induced vitamin B12 deficiency in type 2 diabetic patients. However, the association between vitamin B12 and DR has only been investigated in few studies.Materials and methods: A cross-sectional study was carried out on 123 type 2 diabetic patients...

ea0090p615 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Association between diabetic peripheral neuropathy (DPN) and Hypertiglyceridemia in patients with type 2 diabetes in Georgia

Maghradze Tamar , Kurashvili Ramaz , Shelestova Elena

Background: Diabetic neuropathy is the most prevalent chronic complications of diabetes. This heterogeneous group of conditions affects different parts of the nervous system and presents with diverse clinical manifestations. Diabetic peripheral neuropathy (DPN) is one of the common complication of type 2 diabetes and can lead to foot ulcer, gangrene or amputation. The risk of developing diabetic neuropathy increases with age, diabetes duration and poor control of blood glucose...

ea0090p616 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Gender differences in lower limb amputations among persons with diabetes

Elisabeth Finnes Trine , Valland Susanna , Talsnes Ove , Eik-Nes Sindre , Holvik Kristin

Background and Aim: Recent international studies indicate a secular decrease in the proportion of patients with diabetes who undergo lower limb amputations (LLA). However, our findings suggest that the proportion of diabetics among patients undergoing non-traumatic, non-cancer related lower limb amputations has increased over the past decades despite comprehensive preoperative investigations and other surgical interventions. To further explore the underlying reasons for this, ...

ea0090p617 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Case Report: Atypical presentation of central pontine myelinolysis in hyperglycemia

Gonzalez Lazaro Paloma , Contreras Pascual Cristina , Moreno Tirado Antonio , Zhao Montero Benitez Maria , Jimenez Torrecilla Pedro , Gomez Garcia Ines

Central pontine myelinolysis (CPM) is a neurological disorder typically caused by rapid correction of severe chronic hyponatremia. Conditions causing a hyperosmolar state can also cause CPM, but it is rarely seen in diabetes. We report the case of a 33-year-old woman with personal history of Type 1 Diabetes since she was 9 years old with very poor metabolic control (A1hbC 15%) and microvascular complications, who attended the emergency department due to left hemicranial headac...

ea0090p618 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Oxidative Stress and Biochemical Indicators In T2DM

Trapali Maria , Mavrogianni Theodora , Chaniotis Dimitrios , Karkalousos Petros

Introduction: Many complications of T2DM, including retinopathy and renal failure, have been associated with glucose and triglyceride metabolism. Hyperglycemia causes oxidative stress mainly due to the enhanced production of mitochondrial reactive oxygen species ROS, non-enzymatic protein glycosylation and glucose autoxidation. Elevated levels of free fatty acids can contribute to oxidative stress by promoting mitochondrial oxidation. Furthermore, oxidative stress caused by hy...

ea0090p619 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Pancreatic autoimmunity in the diagnosis of type 1 diabetes: usefulness of zinc transporter 8 and proposal for stepwise assessment

Rodriguez Escobedo Raul , Gonzalez Martinez Silvia , Alonso Felgueroso Carlos , Morales Sanchez Paula , Diaz Naya Lucia , Delgado Elias , Luis Menendez Torre Edelmiro

Introduction: Zinc transporter 8 (ZnT8) autoimmunity has been established as one of the markers for the diagnosis of type 1 diabetes (T1D) along with glutamate decarboxylase (GAD) and tyrosine phosphatase IA-2 (IA-2) antibodies. The aim of this study is to understand the status of pancreatic autoimmunity in the diagnosis of T1D, with special attention to the usefulness of ZnT8. In addition, as a second objective, we study the proposal to perform the assessment of pancreatic au...

ea0090p620 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Mutation in MT-TV gene – a novel etiology of mitochondrial diabetes?

Ornelas Mariana , Resende Eduarda , Gouveia Pedro , Maritza Pontes Santos Sa Elena , Maria Morna Ferreira Margarida

Mitochondrial diseases are rare conditions with a wide phenotypic range. The inability of dysfunctional mitochondria to produce sufficient ATP results in multi-organic defects dependent on high aerobic such as pancreas. The most common endocrine disease related to mitochondrial diseases is diabetes mellitus and it is thought to be secondary to insulin deficiency. A 26-year-old pregnant patient with 26 weeks gestational age was referred to an Endocrinology appointment ...

ea0090p621 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Asymptomatic Pyuria/Bacteriuria and Urinary Tract Infection Risk in Women Initiated SGLT2 Inhibitors

Akkus Erman , Gokcay Canpolat Asena , Demir Ozgur , Corapcıoğlu Demet , Sahin Mustafa

Objective: The study aims to investigate the association between asymptomatic pyuria/bacteriuria at the initiation of SGLT2 inhibitors (SGLT2i) and urinary tract infection (UTI) risk in a cohort of women with type 2 diabetes mellitus (T2DM) (NCT05520684).Methods: The female outpatients with T2DM under follow-up in the department of internal medicine and initiated SGLT2i (dapagliflozin/empagliflozin) were included between February and September 2022. Excl...

ea0090p622 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Hybrid Closed Loop in obesity: to each his own (algorithm)!

Tecce Nicola , Verde Ludovica , Docimo Annamaria , Chirico Giovanni , Barrea Luigi , Colao Annamaria , Muscogiuri Giovanna

Introduction: Currently, patients with type 1 diabetes (T1D) have the option of being treated with Hybrid Closed Loop (AHCL) systems, which allow insulin delivery to be modulated according to glycemic values. These systems do not allow any kind of anthropometric or laboratory characteristics to be used to enhance the devices’ capabilities. Thus, the aim of our study was to investigate the efficacy of AHCL systems in subjects with T1D and with obesity compared to normal-we...

ea0090p623 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Hirata disease: a rare cause of hypoglycemia

Rusu Eva , Stanoiu- Pinzariu Oana , Emanuela Georgescu Carmen

Introduction: Hirata disease (or Insulin autoimmune syndrome) is characterized by the presence of high concentrations of insulin autoantibodies leading to hyperinsulinemic hypoglycemia in individuals with no history of prior exposure to exogenous insulin. Etiopathogenesis is not completely elucidated, it’s considered to result from the interaction of genetic predisposition and environmental triggers such as: medications (methimazole, carbimazole, alpha-lipoic acid, captop...

ea0090p624 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Changes of Cholesterol and Cardiovascular Risk Before and After Initiation of Statin Therapy

Simon Gyorgy , Regina Castro M. , Caraballo Pedro

Introduction: Cholesterol management is essential to prevent coronary artery disease (CAD) and related complications. Lifestyle changes are first treatment, followed by statin therapy. Multiple studies have shown statins to effectively reduce the risk of cardiovascular complications. LDL cholesterol is the main measure to assess impact of statin therapy. However, CAD risk also depends on other often neglected risk factors. We present preliminary data of the evaluation of the s...

ea0090p625 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Biomarkers of prostate cancer transgenerational transmission risk in the progeny of obese fathers subjected to dietary correction

Pereira Mariana , Pereira Sara C. , Rato Luis , Oliveira Pedro F. , Alves Marco

Metabolic disorders, such as overweight and obesity, are serious health societal challenges due to their high incidence rates. Obesity leads to metabolic dysregulation, promoting hormonal imbalance, oxidative stress, and a chronic inflammation state. Eating habits towards the intake of highly caloric fat-rich regimes induce epigenetic changes in the information transgenerationally transmitted. Furthermore, obesity promotes carcinogenesis. It is known that the prostate is sensi...

ea0090p626 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Comparison of the Effects of a Ketogenic Diet and an Isocaloric Balanced Diet administered to Obese patients on Quality of Life and Sleep: a Randomized Clinical Trial

Gangitano Elena , Elena Spoltore Maria , Lenzi Andrea , Gnessi Lucio , Ray David

Introduction: The prevalence of obesity and metabolic disturbances is worryingly increasing worldwide, therefore the study of their pathophysiology is extremely important to find new strategies for their treatment. Obesity has an impact not only on the metabolism of the patients, but also profoundly influence their daily life, and potentially affect the quality of life and the quality of sleep. These latter are strictly related to the circadian rhythm of the individuals that, ...

ea0090p627 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Impact of Bariatric Surgery in Metabolic-Associated Fatty Liver Disease

Verissimo David , Vinhais Joana , Machado Vania , Silva Sandra , Ivo Catarina , Claudia Martins Ana , Silva Joao , Passos Dolores , Lopes Luis , Jacome Castro J , Marcelino Mafalda

Introduction: In 2020, a group of experts proposed to change the term “non-alcoholic fatty liver disease” (NAFLD) to “metabolic-associated fatty liver disease” (MAFLD), which includes hepatic steatosis (HS) (using imaging or analytical scores) associated with overweight or obesity, type 2 diabetes (T2D), or the presence of two other metabolic disorders.Objectives: Analyse the impact of bariatric surgery on MAFLD.<p class="abstext"...

ea0090p628 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Features of the Course of Covid-19 in Patients With Metabolic Syndrome

Mirzaeva Umida

The COVID-19 pandemic has forced the dispatch of significant efforts to identify prognostic factors development of critical conditions and death. Elderly age, cardiovascular disease (CVD), blood sugar diabetes, chronic lung disease, arterial hypertension was associated with an increased risk of death with COVID-19. Metabolic syndrome is a significant comorbid pathology, which increases the risk of developing life-threatening complications and unfavorable outcome of the coronav...

ea0090p629 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

The new anthropometric indices and atherogenic indices are correlated with lipid status in women with PCOS

Nowak Justyna , Jabczyk Marzena , Jagielski Paweł , Hudzik Bartosz , Kulik-Kupka Karolina , Zubelewicz-Szkodzińska Barbara

Introduction: Polycystic ovary syndrome (PCOS) contributes to endocrine and metabolic complications. Cardiovascular disease (CVD) is a leading cause of mortality and morbidity worldwide. Identification of the subpopulations with a higher risk of developing CVD and lipid metabolic disorders is crucial, particularly in PCOS patients.Aim: The aim of this study was to investigate the usefulness of new anthropometric indices such as BAI, VAI, LAP, BRI, ABSI a...

ea0090p630 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Urinary C-peptide to creatinine ratio (UCPCR) as indicator for metabolic risk in apparently healthy adults - a BioPersMed cohort study

Reintar Sharmaine , Pochhacker Magdalena , Obermayer Anna , Eberhard Katharina , Zirlik Andreas , Verheyen Nicolas , Haudum Christoph , Pieber Thomas , Sourij Harald , Obermayer-Pietsch Barbara

Background: C-peptide consists of 31 amino acids, synthesized in the beta cells of the pancreas and co-secreted along with insulin. Hence, serum C-peptide may be the preferred diagnostic biomarker for evaluating beta cell function compared to insulin. The urinary C-peptide to creatinine ratio (UCPCR) recently gained attention as a non-invasive biomarker for evaluating and monitoring metabolic risk. In this study, we aimed to characterize guiding values of UCPCR in healthy indi...

ea0090p631 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Using digital technology to improve understanding and adherence of clinical guidelines for diabetic emergencies

Chopra Tanya , Patel Monali , Furness Hugh , Hui Elaine

Background: Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycaemic state (HHS) are common diabetic emergencies. However, the associated morbidity and mortality remains substantial. Non-specialist trainee healthcare professionals (HCPs) are usually the first point of contact in managing these patients in the acute medical setting. It is therefore essential that these trainees are confident in the management of these emergencies. Aims: Our aim was to ...

ea0090p632 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Changing clinical features of diabetic ketoacidosis: any impact of SGLT2 inhibıtors is there?

Genc Selin , Evren Bahri , Selcuk Yiğit Onur , Şahin İbrahim

Aims: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) increase the risk for diabetic ketoacidosis, particularly in patients with type 1 diabetes (T1DM). We aimed to determine whether SGLT2i use increase the risk of euglycemic diabetic ketoacidosis (euDKA) and to indicate its demographic, clinical features.Methods: We performed a retrospective cohort study of 51 patients over 18 years-old admitted to emergency unit at a tertiary care hospital from 2018...

ea0090p633 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

The prevalence of vitamin D deficiency in hospitalized patients with COVID-19 decreased significantly during the pandemic in Slovakia between the years 2020-2022

Smaha Juraj , Jackuliak Peter , Kužma Martin , Max Filip , Binkley Neil , Payer Juraj

Background: The coronavirus disease 2019 (COVID-19) pandemic led to changes in lifestyle, which could influence vitamin D status on a population level. The purpose of our study was to compare 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized because of severe COVID-19 during two waves of the pandemic (2020/21 vs. 2021/22).Materials and methods: We analyzed 101 patients (61 males/ 40 females) hospitalized in the internal medicine department of...

ea0090p634 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Adverse impact of Covid-19 pandemic on the glycemic status of persons with diabetes: Experience from a large Indian cohort

Baruah Manash , Bhuyan Seema

Introduction: There is a general assumption that glycemic control in persons with diabetes(PWD) has deteriorated since the onset of COVID-19 pandemic. We conducted this to compare the glycemic status of a very large cohort of PWD prior to COVID-19 outbreak with that of a similar cohort post onset of the outbreak. Methods: This was a retrospective study wherein entire data of glycated hemoglobin (HbA1c)% available in the hospital database since 3rd Octobe...

ea0090p635 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Assesment the effects of long-term leptin replacement therapy on ocular structures in the patients with congenital leptin deficiency: a case-control study

Nur Firat Sevde , Candan Ozlem

Purpose: Congenital leptin deficiency (CLD) is an extremely rare condition. The effects of the disease and leptin treatment on ocular structures are unknown in this patient group. In our study, we planned to compare the ocular findings of patients who received leptin replacement therapy due to leptin deficiency with the control groupMethods: In this prospective, cross-sectional comparative study, six patients with a diagnosis of congenital leptin deficie...

ea0090p636 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Time restricted feeding is a non-pharmacological strategy against diet induced obesity

Fatima Nazmin , Sonkar Gyanendra Kumar

Background: Obesity is the major health problem in both developed and developing countries, due to increasing its rate there is a new strategy to prevent obesity by time restricted feeding (TRF). The aim of our study is the effect of TRF intervention on diet induced obese rats and their association with circadian gene expression.Method: Total 15 Wistar rats were included in our study and divided into two groups. Control group and High Fat diet (HFD) grou...

ea0090p637 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Non-invasive methods of assessment of liver fibrosis in patients following chemotherapy

Prokopchuk Oksana , Hospodarskyy Ihor , Danchak Svitlana , Kozak Olha , Havrulyuk Nadiia

Toxic hepatitis is a diffuse inflammatory process in the liver which is caused by the impact of industrial poisons of hepatotoxic action in doses exceeding the maximum allowable concentration. Given the complexity of differentiation, in fact, the symptoms of the disease from possible side effects of treatment, the statistics of the prevalence of the disease in this profile is quite ambiguous. Data from clinical studies show that in the structure of acute and chronic liver dise...

ea0090p638 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Intake of Fruit and Glycemic Control in Korean Patients with Diabetes Mellitus

Yoon Eunju , Suh Sunghwan

Background: Despite the well-recognized health benefits of fresh fruit consumption, substantial uncertainties remain about its potential effects on glycemic control in patients with type 2 diabetes mellitus (T2DM).Methods: We examined the association of fresh fruit consumption and glycemic control in patients with T2DM using data from the 7th Korea National Health and Nutrition Examination Survey. Study samples were divided into 3 groups based on the wee...

ea0090p640 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Angiotensin-Converting Enzyme (ACE) Level, But Not ACE Gene Polymorphism, Is Associated with Prognosis of COVID-19 Infection: Connection Between Type 2 Diabetes, Hypertension and Renin-Angiontensin-Aldosteron System

Elbasan Onur , Bayram Feyza , Dincer Yazan Ceyda , Apaydin Tugce , Dashdamirova Saida , Polat Hamza , Arslan Ebru , Yılmaz İpek , Karimi Nastaran , Erturk Şengel Buket , Yılmaz Sultan , Faruk Celik Omer , Ata Pınar , Haklar Goncagul , Ilıksu Gozu Hulya

Introduction: Renin-angiotensin-aldosterone system was shown to be activated in severe COVID-19 infection. We aimed to investigate the relation between angiotensin converting enzyme (ACE) levels, ACE gene polymorphism, type 2 diabetes (T2DM), and hypertension (HT), and the prognosis of COVID-19 infection.Methods: Clinical features of adult patients with SARS-CoV-2 infection diagnosis were analyzed. ACE gene analysis and ACE level measur...

ea0090p641 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Cancer, cardiovascular disease and all-cause mortality in Iraqi- and Swedish-born individuals in Sweden - the MEDIM cohort study

Fadhel Dhaher Nadine , Pikkemaat Miriam , Shaat Nael , Nilsson Anton , Bennet Louise

Background: Immigrants from the Middle East to Sweden have a twice as high prevalence of type 2 diabetes (T2D) and obesity as native-born Swedes. Both obesity and T2D have been linked to increased incidence of cancer, cardiovascular disease (CVD) and all-cause mortality (ACM); however, data on differences between ethnicities are scarce. Aims: In a population-based cohort we aimed to study the impact of Middle Eastern and European ethnicity on ACM, cancer...

ea0090p642 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Abdominal pain in pediatric diabetic ketoacidosis: a single center study

Suchok Svitlana , Yakymenko Oleksandr

Background: Despite typical constitutional findings (polyuria, weight loss, and polydipsia), clinical presentation of diabetic ketoacidosis also includes nausea, frequent vomiting and abdominal pain. Moreover, diffuse abdominal tenderness and diminished or absent peristalsis might mimic acute abdomen in pediatric patients. There is paucity of published data regarding prevalence, dynamics and associated laboratory findings in pediatric patients with abdominal pain in DKA.<p...

ea0090p643 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Physical activity assessment is crucial for obesity risk prediction in adolescent patients

Totomirova Tzvetelina , Arnaudova Mila , Arabadzhieva Ivanina , Badarov Teodor

Physical activity is assumed to be a factor of great importance for weight maintenance. Assessment of physical activity in childhood should be done for identifying patients at risk and predicting obesity development. The aim of our study was to assess physical activity’s importance as a risk factor for weight changes in boys and girls 8-18 years aged. The study include 262 subjects (128 boys, 134 girls) in single country region in Bulgaria (mean age 12.02&pm;3.03 years, m...

ea0090p644 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Evaluation of the Frequency of Exocrine Pancreatic Insufficiency in Patients With Diabetes Mellitus

Furkan Engurulu Sadi , Ozdemir Nilufer , Can Guney Sedat , Erdal Serkan , Taneli Fatma , Kasap Elmas , Hekimsoy Zeliha

Introduction and Aim: In our study, the frequency of exocrine pancreatic insufficiency, and its relationship with the duration of diabetes and the level of glycemic control and other complications of diabetes were investigated in patients with diabetes mellitus.Materials and Methods: This paper was supported by Manisa Celal Bayar University Scientific Research Projects Coordination Unit, Project Number 2021-086. A total of 249 diabetic patients, 21 with ...

ea0090p645 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Epidemio-clinical and microbiological profile of Staphylococcus aureus bacteremia in diabetics

Lachiheb Nabil , Ichrak Bougharriou , Omar Gargouri , Ines Bartegi , Khouloud Mnif , Adnene Hammami , Senda Mezghani , Jemaa Mounir Ben

Purpose: Diabetes is a major risk factor for Staphylococcus aureus (SA) bacteremia. The purpose of this work is to study the epidemiological, clinical and microbiological profile of SA bacteremia in diabetics.Patients and methods: Retrospective study conducted in the infectious diseases department of Sfax between January 2003 and April 2022 (19 years), including all diabetics admitted for SA bacteremia (at least one positive blood culture).<p class="...

ea0090p646 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

A Case of Diabetes Mellitus Following the COVID-19 Vaccine

Calapkulu Murat

A Case of Diabetes Mellitus Following the COVID-19 VaccineBackground: Coronavirus disease-2019 (COVID-19) is a public health issue worldwide. Although COVID-19 vaccines are one of the most effective strategies against COVID-19, it has been reported in recent publications that they can trigger endocrine diseases. Herein, we aimed to present a 37-year-old male patient who had polydipsia, polyuria, thirst, fatigue, and loss of appetite a month after the fir...

ea0090p647 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

New onset diabetes mellitus and thyroid dysfunction following Prembolizumab – a case report

Matos Tania , Dias Daniela , Silvestre Catarina , Serra Filipa , Sapinho Ines

Introduction: Prembrolizumab, a programmed cell death protein 1 (PD-1) inhibitor, is one of the immune checkpoint inhibitors (ICI) that have revolutionized cancer therapy. However, ICIs can also trigger immune-related adverse events (irAEs) in different organ systems, including endocrine glands. While thyroid dysfunction is among the most common endocrinopathies reported, ICI-induced diabetes mellitus (DM) is extremely rare, with an overall incidence ranging from 0.9 to 2%.</p...

ea0090p648 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Five-year trends of Turkish nationwide survEy of glycemic and other Metabolic parameters of patients with type 2 Diabetes (TEMD-2 study), 2017-2022

Sonmez Alper , Haymana Cem , Demirci İbrahim , Cetinarslan Berrin , Gonen Sait , Murat Akbas Emin , Yenidunya Yalin Gulsah , Avci Ugur , Tasci Ilker , Salman Serpil , Bayram Fahri , Satman Ilhan , Study Group TEMD-2

Objective: Establishing good metabolic control is essential to prevent morbidity and mortality in patients with type 2 diabetes (T2DM). This nationwide survey is performed five years after the first national TEMD study, to search for any improvement in attaining glycemic and metabolic targets in Turkish patients with T2DM.Methods: The nationwide, multicenter survey consecutively enrolled patients who were under follow up for at least a year in tertiary c...

ea0090p649 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Serum Follistatin-Like-1(FSTL-1) Levels in Gestational Diabetes and The Role of FSTL-1 Gene Polymorphism in the Development of Gestational Diabetes Mellitus

Celik Ender , Akbaba Gulhan , Edgunlu Tuba , Akbaba Eren , Pirincci Fatih , Cinar Nese

Introduction: Gestational Diabetes Mellitus (GDM) is associated with maternal and perinatal morbidity. Follistatin-like 1 (FSTL-1), also known as TGFB-beta-stimulated clone 36 (TSC-36), is a glycoprotein cardiokine reported to be associated with insulin resistance and inflammatory processes. To date, there is no study evaluating the effect of FSTL-1 gene polymorphism on the development of GDM in the literature. In this study, we aimed to investigate the effect of serum FSTL-1 ...

ea0090p650 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Insulin adherence in type 1 diabetes: about 69 cases (Preliminary results)

Gueddari Amine , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Insulin, an essential treatment for type 1 diabetes, must be implemented as soon as diabetes is discovered. It helps to ensure glycemic control. Poor therapeutic compliance may be responsible for the development and progression of complications related to glycemic disorders.Objective of the study: Assess insulin adherence in type 1 diabetes and study the consequences on glycemic control.Materials and methods: This is ...