Calcium and Bone

ea0090p25 | Calcium and Bone | ECE2023

Expression of genes involved in parathyroid tumorigenesis identified different gene signatures in parathyroid adenomas

Verdelli Chiara , Maggiore Riccardo , Stefania Tavanti Giulia , Corbetta Sabrina

The expression of key molecules involved in fundamental cell processes and epigenetic gene expression modulation is altered in human parathyroid tumours, due to gene mutations, loss of heterozygosity, aberrant gene promoter methylation, DNA copy number variations. We performed a gene profiling of 26 parathyroid tumorigenesis-related genes in a series of 32 sporadic parathyroid adenomas (PAds) surgically removed from patients with primary hyperparathyroidism, with the aim to de...

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ea0090p26 | Calcium and Bone | ECE2023

Long-term trajectories of bone metabolism parameters and bone mineral density (BMD) in obese patients treated with metabolic surgery: a real-world, retrospective study

Greco Carla , Passerini Francesca , Coluccia Silvia , Teglio Marta , Bondi Mario , Mecheri Fouzia , Trapani Vincenzo , Volpe Alessandro , Toschi Patrizia , Madeo Bruno , Simoni Manuela , Rochira Vincenzo , Santi Daniele

Background and Aim: Potential adverse effects of metabolic surgery on skeletal integrity remains an important concern. Bone loss is common after surgery due to multiple factors including vitamin D deficiency, altered calcium metabolism, mechanical load reduction and hormonal pattern changes. It is still not clear if the effects on bone health and calcium homeostasis vary according to each surgical technique. Further, long-term data of different surgical approaches are poor. Th...

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ea0090p27 | Calcium and Bone | ECE2023

Evaluation of PTH deprivation effects on anxiety and stress response in a rat model of Chronic Post-Surgical Hypoparathyroidism

Saponaro Federica , Chiellini Grazia , Dettori Cristina , Scalese Marco , Ronca Francesca

Introduction: Hypoparathyroidism (HypoPT) is a rare endocrine disease which is characterized by hypocalcaemia and undetectable or inappropriately low serum parathyroid hormone (PTH). Post-surgical HypoPT (PS-HypoPT) is the most common cause, caused by accidental parathyroid removal/injury during neck surgery. From a neuropsychological standpoint, patients with PS-HypoPT present cognitive and neuropsychological symptoms: the more plausible pathophysiological mechanism resides i...

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ea0090p28 | Calcium and Bone | ECE2023

Clinical application of vitamin D metabolites measurement using LC-MS/MS – a case of a patient with persistent hypercalcemia and two pathogenic mutations in CYP24A1 gene and parathyroid adenoma

Leszczynska Dorota , Szatko Alicja , Latocha Julia , Kochman Magdalena , Duchnowska Maria , Wojcicka Anna , Misiorowski Waldemar , Zgliczyński Wojciech , Glinicki Piotr

Introduction: 24-hydroxylase, encoded by a CYP24A1 gene, is a crucial enzyme entailed in catabolism of vitamin D. Loss-of-function mutations of CYP24A1 result in hypercalcemia, not adequately concomitant high levels of 1,25(OH)2D and low PTH levels. The variety of clinical manifestations depends on age mutations can lead to fatal infantile hypercalcemia among neonates (typically precipitated by supplementation of vitamin D), whereas adults symptoms are usually mil...

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ea0090p29 | Calcium and Bone | ECE2023

TransCon PTH Improves Health-Related Quality of Life and Reduces Work Limitations in Adults With Hypoparathyroidism: Patient-Reported Outcomes in the Phase 3 PaTHway Trial

Palermo Andrea , Khan Aliya , Rubin Mishaela , Schwarz Peter , Shoback Dolores M. , Gagnon Claudia , Cetani Filomena , Clarke Bart L. , Tsourdi Elena , Kohlmeier Lynn , Sikjaer Tanja , M Kaiser Stephanie , Lai Bryant , Le John , Ukena Jenny , Sibley Christopher , Shu Aimee , An Xubei , Noori Wahidullah , Smith Alden , Vokes Tamara J.

Background: Individuals with hypoparathyroidism often experience a range of symptoms associated with reduced health-related quality of life (HRQoL) and work productivity. Conventional therapy aims to alleviate hypocalcemia and acute symptoms but fails to restore normal parathyroid hormone (PTH) physiology or improve HRQoL. In the PaTHway trial, 79% of participants treated with TransCon PTH vs. 5% placebo (P<0.0001) met the primary efficacy endpoint (normal serum c...

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ea0090p30 | Calcium and Bone | ECE2023

In vitro study of rapid non-genomic effects of 25(OH)D3 in preosteoblastic cells

Donati Simone , Palmini Gaia , Aurilia Cinzia , Falsetti Irene , Marini Francesca , Galli Gianna , Zonefrati Roberto , Iantomasi Teresa , Luisa Brandi Maria

Background: Calcifediol (25(OH)D3), the major circulating form and the direct precursor of the biologically active form of vitamin D, has been identified as an agonist ligand for vitamin D receptor (VDR) with anti-proliferative effects and gene regulatory function despite having a lower receptor affinity respect than the biologically active form of vitamin D3. In fact, recent studies have suggested that 25(OH)D3 can regulate gene expression by ...

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ea0090p31 | Calcium and Bone | ECE2023

Bone mineral density in children and adolescents with Cystic Fibrosis

Tamer Gizem , Gerardus Maria Arets Hubertus , Kors van der Ent Cornelis , Margo van Santen Hanneke , Jacoba van der Kamp Hetty

Background: Bone health can be affected in (young) adults with Cystic Fibrosis (CF) due to different risk factors in childhood. We aimed to analyze the prevalence of low bone mineral density (BMD) during childhood in patients with CF, its risk factors and course in time.Methods: A longitudinal prospective cohort study was performed in children with CF aged 8-18. Anthropometric, DEXA scans and endocrine data were collected. BMD z-scores were adjusted for ...

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ea0090p32 | Calcium and Bone | ECE2023

Plasma Sodium Increase Is Associated With an Increase in Bone Formation in Outpatients With Chronic SIAD - A Predefined Secondary Analysis of the SANDx Trial

Monnerat Sophie , Refardt Julie , Potasso Laura , Meier Christian , Christ-Crain Mirjam

Introduction: Hyponatremia is the most common electrolyte disorder encountered in clinical practice and is associated with increased mortality and morbidity, including an increased risk for osteoporosis and fragility fractures. Preclinical studies suggest osteoclast upregulation whereas a clinical study showed improved osteoblast fuction after hyponatremia normalization in hospitalized patients with SIAD.Methods: This is a secondary analysis of a double-...

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ea0090p33 | Calcium and Bone | ECE2023

Heart rate and blood pressure, but not pulse wave velocity, are higher among adults with hereditary hypophosphatemia compared to healthy controls: a cross-sectional study

Espersen Rasmus , Beck-Nielsen Signe , Rejnmark Lars

Introduction: Hereditary hypophosphatemia (HH) are rare diseases, characterized by increased levels of fibroblast growth factor 23 (FGF23), excessive renal phosphate wasting and inappropriately low 1,25-dihydroxy-vitamin D causing hypophosphatemia. In children, the diseases manifest as rickets and osteomalacia, in adults only osteomalacia. Studies in cardiovascular risk among patients with HH are few and inconclusive. Some have found left ventricular hypertrophy in children an...

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ea0090p34 | Calcium and Bone | ECE2023

Two cases of parathyromatosis in patients with recurrent primary hyperparathyroidism

Matejkova Behanova Magdalena , Libansky Petr , Vaculova Marketa , Chmelova Renata , Personova Kateřina , Vcelak Josef , Vlcek Petr

Introduction: Parathyromatosis is a rare cause of recurrent hyperparathyroidism defined as small nodules of hyperfunctioning parathyroid tissue in the soft tissues of the neck or mediastinum. The most common cause is probably the implantation of parathyroid cells into surrounding tissue during surgery and the risk of parathyromatosis increases with repeated parathyroid surgery. There is an overlap in the histologic features in parathyromatosis, atypical adenoma, and parathyroi...

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ea0090p35 | Calcium and Bone | ECE2023

Impact of a single oral bolus of 120,000 IU of cholecalciferol on vitamin D metabolites in the elderly: the results of randomized open study

Leszczynska Dorota , Szatko Alicja , Kowalski Konrad , Raczkiewicz Dorota , Ostrowska Magdalena , Misiorowski Waldemar , Zgliczyński Wojciech , Glinicki Piotr

Background: Vitamin D is a dietary micronutrient responsible for calcium and phosphorus metabolism and multiple extraskeletal actions. The assessment of vitamin D status is commonly based on measurement of 25(OH)D total concentration in serum. However, the usage of LC-MS/MS analytical technique allows to reliably assess a panel of vitamin D metabolites in serum or plasma, which may help to investigate the metabolic paths of vitamin D, especially in populations at risk of defic...

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ea0090p36 | Calcium and Bone | ECE2023

No effects of high-dose vitamin D supplementation on white blood cell count, CRP and risk of upper respiratory tract infections in infertile men – Secondary analyses from a randomized clinical trial

Wall-Gremstrup Gustav , Holt Rune , Juul Anders , Joergensen Niels , Blomberg Jensen Martin

Background: vitamin D has been associated with different beneficial effects on the immune system. The vitamin D activating (CYP2R1 and CYP27B1) and inactivating (CYP24A1) enzymes, including the vitamin D receptor (VDR) are expressed in several types of white blood cells (WBC). A range of studies have explored whether vitamin D positively affects risk of and severity of respiratory tract infections such as tuberculosis, influenza, cold and COVID-19.Object...

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ea0090p37 | Calcium and Bone | ECE2023

Vertebral fractures in acromegaly

Sorohan Madalina , Baciu Ionela , Galoiu Simona , Caragheorgheopol Andra , Iordachescu Carmen , Poiana Catalina

Introduction: Acromegalic bone disease is characterized by an increased prevalence of fragility vertebral fractures (VFs). However, an effective, non-invasive and cost-efficient imaging technique that can diagnose early bone alterations in this category of patients is yet to found. The use of bone mineral density (BMD) is not as useful as in other causes of osteoporosis as excess GH leads to specific microarchitectural alteration of trabecular bone, which dont translate ...

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ea0090p38 | Calcium and Bone | ECE2023

Association of Dietary Intakes of Calcium/Phosphorous with Biochemical Osteomalacia and its Components

Nasser Al-Daghri , Sabico Shaun , Wani Kaiser , Danish Hussain Syed , Yakout Sobhy , Aljohani Naji , Uday Suma , Hogler Wolfgang

Background: Our previous study revealed a high prevalence of abnormal mineralization markers namely low 25 hydroxyvitamin D (47.9%); high serum alkaline phosphatase (3.7%) and low calcium-phosphate product (9.8%) suggestive of biochemical signs of osteomalacia (OM, defined as any two of these risk factors). OM was more prevalent in girls (11.2%) compared to boys (5.0%). In this follow-up study, we aimed to evaluate if biochemical OM was associated with low intakes of calcium a...

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ea0090p39 | Calcium and Bone | ECE2023

4D-CT parathyroid increases the likelihood of localising parathyroid adenoma (PA) in patients with primary hyperparathyroidism (PHPT) and non-diagnostic Tc99m-Sestamibi+I-123 subtraction scan

Thin Khine May , Pandit Manish , Lee Brian

Introduction: Tc99m-Sestamibi+I-123 subtraction using planar and SPECT-CT (SPECT-CT 99mTc-MIBI parathyroid) is commonly used to investigate primary hyperparathyroidism (PHPT). We previously reported the sensitivity and positive predictive value of 4D CT parathyroid as the second line investigation in patients with non-diagnostic SPECT-CT 99mTc-MIBI parathyroid (https://www.endocrine-abstrac...

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ea0090p40 | Calcium and Bone | ECE2023

Polymorphisms in genes related to iron metabolism and DNA methylation and their interaction with estradiol in susceptibility to osteoporosis in postmenopausal women

Aguiar Laura , Ferreira Joana , Paula Barbosa Ana , Rui Mascarenhas Mario , Faustino Paula , Inacio Angela , Bicho Manuel

Introduction: Osteoporosis is a multifactorial disease characterized by reduced bone mass and increased risk of fragility fractures. Menopause predisposes women to osteoporosis due to declining estrogen levels. Iron is known to play a relevant role in the development of osteoporosis since iron suppresses osteoblast formation and may also stimulate osteoclast resorption of bone. Also, homocysteine is a known risk factor for osteoporotic fractures and is related to DNA methylati...

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ea0090p41 | Calcium and Bone | ECE2023

Vitamin D status and biomarkers of bone health in diabetic adolescents and children in a multi-ethnic cohort

Ho Clement K. M. , Lee Nicole K. L. , Vasanwala Rashida F.

Objectives: This prospective study aimed at investigating (1) the prevalence of vitamin D deficiency and insufficiency in diabetic adolescents and children in a multi-ethnic cohort, and (2) any association between vitamin D status and ethnic background, glycaemic control (HbA1C), biomarkers of metabolic bone health and lipids.Methodology: Venous blood was drawn from 199 patients with type 1 diabetes (mean age &pm; SD, 8.2 &pm; 3.7 years) and 48 patients ...

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ea0090p42 | Calcium and Bone | ECE2023

A single center experience with opportunistic diagnosis of osteoporosis by artificial intelligence-the time has come

Beeri Yehonatan , Ben-Arie Gal , Shelef Ilan , Fraenkel Merav

Background: Osteoporosis (OP) is underdiagnosed and frequently left untreated. CT derived bone mineral density (BMD) and identification of vertebral compression fracture (VCF) on CT done for another indication are 2 new artificial intelligence (AI) based techniques for opportunistic diagnosis of OP. Our aim was to assess the clinical impact of opportunistic diagnosis of OPMethods: This retrospective study included men and women over age 50, insured by Cl...

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ea0090p43 | Calcium and Bone | ECE2023

Primary hyperparathyroidism in an adolescent presenting with genu valgus progressing to extensive bone disease; a case report

Lakshitha de Silva Nipun , Denagama Jayalath Mihiran , W. K. Chaminda Sampath , Perera Ranga , Karunathilake Chandana

Background: Primary hyperparathyroidism which is rare in adolescents presents commonly with non-specific symptoms and systemic complaints. Though there are few reported cases of genu valgus, progression to extensive bone disease with fractures has not been commonly reported. Additionally, hypercalcaemia at the time of presentation was almost universal.Case presentation: A 12-year-old male had been evaluated for bilateral (left > right) genu valgus an...

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ea0090p44 | Calcium and Bone | ECE2023

CYP24A1 mutation - a rare cause of hypercalcemia and nephrocalcinosis in adulthood

Brunerova Ludmila , Reeš Ondrej , Zoubkova Veronika , Votypka Pavel

Background: CYP24A1 gene encodes the enzyme vitamin D 24-hydroxylase, which converts active vitamin D to inactive metabolites. More than 20 currently described, usually biallelic pathogenic variants of this gene are responsible for idiopathic infantile hypercalcemia manifested typically in childhood (often in newborns) with hypercalcemia, hypercalciuria and nephrocalcinosis. However, a few patients (mostly with monoallelic heterozygous pathogenic variant) can develop mild symp...

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ea0090p45 | Calcium and Bone | ECE2023

Incidence and clinical correlates of persistent hyperparathyroidism among kidney transplant patients at a tertiary specialty center

Bustamante Cassie , Dela Pena Pepito

Background: Secondary hyperparathyroidism (HPT) is a common complication seen in 12-54% of end stage renal disease patients (ESRD), owing to the calcium and phosphorus perturbations in these patients1. Successful kidney transplantation (KT) is expected to correct these abnormalities, however, it is not uncommon for hyperparathyroidism to persists post-transplantation 2,4,5,22. Persistent hyperparathyroidism is associated with significant mortality and mor...

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ea0090p46 | Calcium and Bone | ECE2023

Cardiovascular aspects of primary hyperparathyroidism

Myriam Baltagi , Najla Bchir , Hadj Sliman Chayma Bel , benchhida annam , Chadia Zouaoui , Ouertani Haroun

Introduction: Primary hyperparathyroidism (PHPT) is typically characterized by elevated serum calcium associated with elevated or non-suppressed levels of parathyroid hormone (PTH). These biochemical features are both known to affect the cardiovascular (CV) system. There is a conflicting debate regarding the CV manifestations of PHPT. the aim of our study is to evaluate the cardiovascular profile in patients with PHPT.Methods: We conducted a retrospectiv...

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ea0090p47 | Calcium and Bone | ECE2023

Case Studies of Pet Colina for Hyperparathyroidism Diagosis

Urbon Lopez de Linares Lidia , Garcia Calvo Susana , Maldonado Alfonso , Moreira Manuela

Introduction: The diagnosis of hyperparathyroidism can be challenging especially when surgery is mandatory and imaging techniques can not find the adenoma. PEt colina is a non-invasive diagnostic test that creates images of the parathyroid glands and detects abnormal activity. It is increasingly used and especially useful when there are no pathological findings in parathyroid scintigraphy.Methods: This is a retrospective observational study with data fro...

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ea0090p48 | Calcium and Bone | ECE2023

Primary hyperparathyroidism related to ectopic thymic parathyroid tissue: about two cases

Rekaya Zeineb , Bchir Najla , Chadia Zouaoui , Ghram Lina , Ouertani Haroun

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder most commonly caused by a single adenoma of the parathyroid gland and rarely related to ectopic thymic parathyroid adenoma.Observation: 1st case: we report a case of a 46-year-old woman, diagnosed with PHPT. Scintigraphy concluded to a left inferior parathyroid adenoma. She underwent a focal parathyroid surgery and the adenoma was located in the thymus. The histopa...

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ea0090p49 | Calcium and Bone | ECE2023

Pregnancy and Lactation Associated Osteoporosis -A Rare Case Report

Chanturishvili Ketevan , Zavrashvili Nino , Gvazava Qetevan , Margvelashvili Natia , Shonia Natia

Context: Pregnancy and lactation -associated osteoporosis (PLO) is an uncommon condition affecting women during late pregnancy and the early postpartum period. PLO is manifested with fractures usually in spine or occasionally in the hip with severe and prolonged pain and height loss. Pathogenesis of this rare condition is still not completely understood.Case Presentation: We report a 28 y/o female patient presenting with severe back pain during postpartu...

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ea0090p50 | Calcium and Bone | ECE2023

Impact of the Covid19 pandemic on patients with primary hyperparathyroidism

Hadj Sliman Chayma Bel , Najla Bchir , Myriam Baltagi , Benchhida Annam , Chadia Zouaoui , Ouertani Haroun

Introduction: The development of the Covid-19 pandemic infection, which started in March 2020 in Tunisia, has impacted all medical specialties. Endocrine care professionals were part of this battle, as many patients with endocrine diseases including primary hyperparathyroidism (PHPT) were also affected by the pandemic. the aim of our study was to evaluate the Impact of the Covid19 pandemic on patients with PHPT.Methods: This is a retrospective descriptiv...

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ea0090p51 | Calcium and Bone | ECE2023

Osteoporosis issues & Complementary Medicine: Three years Experiences in Asian population

Pal S , Roy T , Kumari G

Issues: No specific centre in asia for Osteoporosis patients treatment/rehabilitation. We used locally available Complementary Indian Medicines [CAM] for providing home based care in rural/tribal areas.Aims: To provide CAM to poor patients in collaboration with Traditional-faith-hearers. Evaluated cost-efficacy of CAM & response of pain of fractures to CAM alongside analgesics.Methods: from April 2014 to November 2018, 122 pati...

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ea0090p52 | Calcium and Bone | ECE2023

Characteristics of hypoparathyroidism in a tertiary referral hospital

Abderrahim Yosra , Ben Amor Bilel , El Arem Marwa , Bayar Ines , Hajji Ekram , Abid Sana , Marmouch Hela , Sayadi Hanene , Khochteli Ines

Introduction: Hypoparathyroidism (HypoPT) is a rare endocrine disease characterized by abnormally low concentrations of PTH resulting in hypocalcemia. Etiologies are various and are dominated by postoperative HypoPT. HypoPT needs a lifelong treatment and follow-up in order to maintain appropriate calcium levels and prevent chronic complications.Patients and Methods: A retrospective descriptive study was conducted at the endocrinology department in Fattou...

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ea0090p297 | Calcium and Bone | ECE2023

Chronic hypoparathyroidism is associated with skeletal muscle dysfunction and restrictive lung disease

Sahoo Saroj , Anush Babu Takasi , Hashim Zia , Neyaz Zafar , Mani Vinita E. , Jain Neeraj , Bhatia Eesh , Mishra Anjali

Introduction: Whether patients with non-surgical hypoparathyroidism have skeletal muscle dysfunction is not studied. It is also not known if skeletal muscle dysfunction involves respiratory muscles and results in a restrictive lung disease (RLD).Aim: To assess skeletal muscle and pulmonary function in patients with non-surgical hypoparathyroidism, who were asymptomatic for overt muscle and lung diseases.Methods: Thirty patients wit...

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ea0090p298 | Calcium and Bone | ECE2023

Localization studies in 443 patients with primary hyperparathyroidism by using a stepwise approach

Balcı Gulşah , Begum Bahcecioglu Mutlu Adile , Avcı Merdin Fatma , Erdogan Murat

Objective: Primary hyperparathyroidism (PHP) is a common endocrine disorder diagnosed biochemically, common use of autoanalyzers increased the incidence of PHP throughout last decades. Minimally invasive parathyroidectomy has been preferred to the explorative surgical approach due to shorter operating time, lower complication rate, and smaller incision size. Thus localization studies have become very important. We aimed to investigate clinical and laboratory characteristics of...

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ea0090p299 | Calcium and Bone | ECE2023

Parathyroid hormone levels following denosumab therapy vs. zoledronic acid therapy for osteoporosis

Rotman Pikielny Pnina , Hornik Lurie Tzipi , Barzilai-Yosef Liat , Ramaty Erez , Braginski Shapira Sofia , Kasher Miron Michal

Background: Denosumab (DMAb) and zoledronic acid (ZA) are potent, anti-resorptive agents used to treat patients with osteoporosis. It has been suggested that they increase parathyroid hormone (PTH) levels in response to their antiresorptive effect, and that PTH elevation might be responsible for DMAb modeling actions on bone. The timeline and magnitude of PTH elevation post-DMAb and ZA has not been characterized in a large patient population.Objective: T...

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ea0090p300 | Calcium and Bone | ECE2023

Bioluminescence and autofluorescence of parathyroid glands to identify an intra-thyroidal parathyroid tumour

Lin Zhimin , Wai Kit Lee James , Yuan Ngiam Kee

Bioluminescence is bringing new and exciting possibilities to the field of endocrine surgery, because we are able to better harness the property of autofluorescence of the parathyroid glands. Parathyroid glands have an inherent ability to produce infra-red autofluorescence at the wavelength of 820 nm to 830 nm, if the gland absorbs light at the wavelength of 750 nm. With highly sensitive technology and the ability to filter out other reflected light and noise, it is now possib...

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ea0090p301 | Calcium and Bone | ECE2023

Healthcare resource utilization associated with post-surgical and non-surgical chronic hypoparathyroidism in England: A linked Clinical Practice Research Datalink, Hospital Episode Statistics, and Office for National Statistics retrospective analysis

Smith Alden , Rice Caoimhe T. , Carvalho Sara J. , Davidson Jennifer , Hamlyn Mico , Sibley Christopher , Noori Wahidullah

Background: Hypoparathyroidism, a rare endocrine disorder characterised by low serum calcium due to low or insufficient parathyroid hormone levels, most commonly occurs post-surgery although can also occur due to predisposing genetic conditions or idiopathically. Hypoparathyroidism requires long-term medical management to minimise complications and detrimental impacts on health-related quality of life. Few real-world studies, particularly in the UK, have quantified healthcare ...

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ea0090p302 | Calcium and Bone | ECE2023

Evaluation of Breast Calcification, Calcification Characteristics and BI-RADS (Breast Imaging-Reporting and Data System) Categories in Patients with Primary Hyperparathyroidism

Dilek Dellal Kahramanca Fatma , FAKI Sevgul , Yiğit Koroğlu Ekin , Ozsoy Arzu , Dirikoc Ahmet , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

Aim: It is hypotethically thought that increased frequency of breast cancer in patients with primary hyperparathyroidism(PHPT)may be due to the fact that calcium accumulation in the breast may be higher in patients with PHPT giving rise to more breast-related examinations. Although there are many studies or case reports showing calcification in many organs and tissues, in PHPT, there is not any study investigating breast calcification in these patients in the literature. We ai...

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ea0090p303 | Calcium and Bone | ECE2023

SPECT/CT parathyroid scintigraphy in primary hyperparathyroidism: minimizing the risk of negative results by biochemical parameters assessment

Drynda Anna , Kucharczyk Karolina , Sokolowski Grzegorz , Trofimiuk-Muldner Malgorzata , Hubalewska-Dydejczyk Alicja

Primary hyperparathyroidism (PHP) diagnosis in clinical practice is based on biochemical blood tests. Since a single parathyroid adenoma causes about 85% of cases, the treatment of choice is parathyroidectomy, preceded by imaging studies. Ultrasound and [99mTc]sestamibi scanning can enable adenoma localization. However, the latter method is of higher sensitivity, especially if combined with anatomical imaging. In some cases, the radiotracer uptake in adenoma tissue ...

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ea0090p304 | Calcium and Bone | ECE2023

Evaluation of Laboratory Findings of Primary Hyperparathyroidism in Geriatric Patients

Calapkulu Murat , Erkam Sencar Muhammed , Sakiz Davut , Tekinyildiz Merve , Ozturk Unsal İlknur , Cakal Erman

Evaluation of Laboratory Findings of Primary Hyperparathyroidism in Geriatric PatientsBackground: Primary hyperparathyroidism (PHPT) is an endocrine disease characterized by excessive secretion of parathormone (PTH) from one or more parathyroid glands. In recent studies, it has been reported that the PHPT clinic has turned into a largely asymptomatic disease in recent years. There are few studies on the effect of aging on laboratory find...

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ea0090p305 | Calcium and Bone | ECE2023

A Phase 1/2, Open-Label, Multiple Ascending Dose Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INZ-701 in Adults with ENPP1 Deficiency

Wermers Robert , Fuhr Rainard , Schnabel Dirk , Arnason Terra , Bensacon Alix , Cizman Borut , Wenkert Deborah , Sabbagh Yves , Gunter Kurt

Background: ENPP1 Deficiency is a rare disorder due to inactivating mutations in the ENPP1 gene. It is characterized by low levels of inorganic pyrophosphate (PPi), a critical regulator of mineralization; subsequent pathologic soft tissue calcification results in ~50% infant mortality and life-long musculoskeletal and cardiovascular morbidities. No targeted therapy exists for this disease. INZ-701 is a recombinant ENPP1-Fc investigational product.<p class="abstext...

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ea0090p306 | Calcium and Bone | ECE2023

Surgical fixation of ankle fractures with bioresorbable magnesium implants: A first-in-human HR-pQCT assessment of the implantation site

Foszl Ines , Labmayr Victor , Martina Weinberg Annelie , Holweg Patrick , Obermayer-Pietsch Barbara

Background: Bioresorbable implants should provide stability for fracture healing and resorb thereafter to make implant removal obsolete. Here, we report follow-up data of 6 patients treated with bioresorbable magnesium screws following medial malleolus fractures.Purpose: Assessment of the implantation site and implant resorption of 11 implants in 6 patients with HR-pQCT (high resolution peripheral quantitative computed tomography)....

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ea0090p307 | Calcium and Bone | ECE2023

FGF-23 levels in patients with normocalcemic primary hyperparathyroidism

Chertok Shacham Elena , Maman Nimra , Lazareva Tatyana , Ishay Avraham

Introduction: Normocalcemic primary hyperparathyroidism (NPHPT) is a variant of primary hyperparathyroidism with consistently normal albumin-adjusted or free-ionized calcium levels. It may be an early stage of classic primary hyperparathyroidism or could represent a primary renal or bone disorder or result from another pathophysiologic mechanism leading to invariably elevated PTH levels.Aim of the study: The study aims to check and compare the FGF-23 lev...

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ea0090p308 | Calcium and Bone | ECE2023

Therapeutic Options for Inoperable Local Relapse of Parathyroid Carcinoma with Symptomatic Hypercalcemia: a Case Report

Filipa Araujo Barbara , Carreira Ana , Moreno Carolina , Rodrigues Dircea , Paiva Sandra , Paiva Isabel

Introduction: Parathyroid carcinoma (PC) is an extremely rare malignancy. A complete surgical excision is often difficult, and persistent/recurrent disease occurs in up to 65% of cases. Progression often leads to symptomatic hypercalcemia, the major contributor to poor quality of life and mortality. Treatment options beyond surgical resection are limited. Denosumab is an approved therapy for refractory hypercalcemia of malignancy, and its use in unresectable PC has been descri...

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ea0090p309 | Calcium and Bone | ECE2023

Hyperparathyroidism in pregnancy, should we favour surgical intervention?

Zaina Adnan , Eli Shezifi

Primary hyperparathyroidism (PHPT) during pregnancy is an uncommon condition that may have consequences for either mother, offspring, or both. Treatment can be either surgical or conservative.The study aims: To compare maternal and fetal adverse outcomes between surgically (operated group) vs conservatively (non-operated group) treated mothers with gestational PHPT and to investigate the correlation between serum calcium and PTH values with complication ...

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ea0090p310 | Calcium and Bone | ECE2023

The impact of a post hip fracture FLS on mortality and recurrent fracture - a tertiary medical center retrospective study

Alkobi-Weiss Hadar , Goldbart Adi , Hassan Lior , Polischuk Vera , Press Yan , Siris Ethel , Yoel Uri , Fraenkel Merav

Background: Rates of osteoporosis treatment following hip fractures are low. Fracture liaison service (FLS) has been shown to increase medical treatment for osteoporosis and decrease mortality. The aim of our study was to assess the impact of in hospital FLS on mortality and second hip fracture.Methods: This retrospective study included patients over 65 years of age, insured by Clalit health service who were admitted to Soroka University Medi...

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ea0090p311 | Calcium and Bone | ECE2023

Hypocalcemia and pulseless electric activity revealing chromosome 22q11.2 deletion syndrome in the midst of a conglomerate of potential etiologic factors

Balti Eric , Dashty Husein , Dominique Ballaux , Peter Coremans

Background: Chromosome 22q11.2 deletion syndrome has been reported in about 1 per 347 to 992 living births. Hypocalcemia occurs in up to 80.4% of cases.Case description: A 28-year-old man, known with autism spectrum disorder (ASD), presented at the emergency department (ED) for limbs muscle cramps. Medical history included chronic myeloid leukemia treated with tyrosine kinase inhibitor (TKI) the last 10 years, gastric bypass and recurrent fractures due t...

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ea0090p312 | Calcium and Bone | ECE2023

Teriparatide in the challenging management of hypoparathyroidism, our experience in one medical center in Argentina

Mallea-Gil Susana , Sanchez Yamila , Coca Bibiana , Lopez Cindy , de los Angeles Sosa Maria , Sankowicz Silvina , Marta Aparicio Maria , Ballarino Carolina

Hypoparathyroidism is an endocrine deficiency whose substitution treatment with PTH 1-84 is only available in compassionate use in Argentina. There is a subgroup of patients in which the conventional therapy with calcium, calcitriol, phosphorous chelators, magnesium and diuretics does not reach an adequate clinical and/or biochemical compensation. Although teriparatide (PTH 1-34) is not approved for patients with hypoparathyroidism, it is a plausible therapeutic resource.<...

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ea0090p313 | Calcium and Bone | ECE2023

Permanent Hypoparathyroidism Consecutive to Thyroidectomy: Clinical Characterization in a Tertiary Center in Quito-Ecuador

Baquero Stefany , Guevara Gabriela , Villota Acosta Xavier , Ruiz Urbaez Rossana , Garcia Cristhian , Palacios Antonio , Luis Salazar Vega Jorge

Background: Acquired hypoparathyroidism due to thyroid surgery for thyroid cancer is the most common postsurgical etiology in a tertiary health center in Ecuador. Therefore, the data published from our country is limited. An observational cross-sectional study was carried out to determine the clinical, biochemical and therapeutic characteristics of patients with permanent hypoparathyroidism in the endocrinology department.Results: 102 patients were inclu...

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ea0090p314 | Calcium and Bone | ECE2023

PTH increasing with BMI associated with cortical bone density

Melin Uygur Meliha

Objective: The goal in this study was to evaluate serum parathormone (PTH) and 25-hydroxy-vitamin D (25OHD), calcium levels and bone mineral density (BMD) in patients with obesity and determine the relationship between biochemical bone parameters, body mass index (BMI) and trabecular/cortical BMD over a wide range of body weights.Methods: We examined 337 women (mean age 41.35 years old; BMI 45.47 kg/m2) who were classified into three categorie...

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ea0090p315 | Calcium and Bone | ECE2023

Study on prevalence of hypercalcemia due to chronic liver disease and correlation with its severity

Vijayan Laiju , M V Vimal , Kumar Anish , Prashanth Sunil

Introduction: Chronic liver disease (CLD) is usually not described as a common cause of hypercalcemia unless there is hepatoma. Of late, there are some reports suggesting CLD as a cause for hypercalcemia. The exact mechanism contributing to hypercalcemia in CLD is poorly understood. It usually correlates with the severity of disease.Aim of the study: To assess the prevalence of hypercalcemia in patients with chronic liver disease To study the relation of...

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ea0090p316 | Calcium and Bone | ECE2023

Influence of musculoskeletal status on fracture risk in patients with adult hypophosphatasia

Del Carmen Andreo-Lopez Maria , Contreras Bolivar Victoria , Moratalla-Aranda Enrique , Gonzalez-Cejudo Trinidad , Martinez-Heredia Luis , Andujar-Vera Francisco , Garcia-Fontana Cristina , Garcia-Fontana Beatriz , Munoz-Torres Manuel

Introduction: Hypophosphatasia (HPP) is an inherited disease, characterized by a non-tissue-specific alkaline phosphatase deficiency that leads to abnormal mineralization of bone tissue, which promotes fragility fractures. A defective muscle status could have important clinical repercussions on fracture risk. The aim of this work was to evaluate the relationship between bone and muscle compartment.Material and Methods: Observational cross-sectional study...

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ea0090p317 | Calcium and Bone | ECE2023

Calcinosis cutis as a rare manifestation of primary hyperparathyroidism: a case report

Hamny Illias , Mendes Melanie

Background: Calcinosis cutis is a rare manifestation characterized by calcium deposits in the skin and subcutaneous tissues, mostly found in auto-immune diseases. A case of calcinosis cutis (on the vertex and the face) associated to hyperparathyroidism is presented. We discuss the etiology, diagnosis and management of this rare condition, along with a short review of the literatureCase presentation: We report a case of calcinosis cutis with primary hyper...

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ea0090p318 | Calcium and Bone | ECE2023

Rare association of primary hyperparathyroidism with type 3 multiple autoimmune syndrome

Aycha Ghachem , Elfekih Hamza , Ghada Sabbagh , Saad Ghada , Fatma Barkallah , Hasni Yosra , Chadli Chaieb Molka

Introduction: Primary hyperparathyroidism (PHPT) is most commonly sporadic and in rare circumstances, it can develop as part of multiple endocrine neoplasia (MEN). There are few cases described in the literature reporting an association of PHPT with myasthenia gravis and multiple autoimmune syndrome (MAS). These patients may present only with clinical signs of PHPT making it difficult to suspect the coexistence of MAS. Here, we report the case of type 3 MAS in a woman with PHP...

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ea0090p319 | Calcium and Bone | ECE2023

Unexpected first finding in primary hyperparathyroidism; peripheral giant cell granuloma in the mandibula

Koroğlu İpek , Abidin Sayıner Zeynel , Aytekin Alper , Akarsu Ersin

Aim and Introduction: Peripheral giant cell granulomas (PHDG) are uncommon exophytic lesions of the oral cavity that originate from the periosteum or periodontal membrane as a polypoid mass. Mandibular involvement is more common than maxillary involvement. Patients with primary hyperparathyroidism can infrequently exhibit PHDG in the early stages of the disease. We wanted to present our case who was examined for giant cell granuloma developing in the mandibula and was found to...

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ea0090p320 | Calcium and Bone | ECE2023

Evaluation of bone impact in a population of patients with Cushing’s disease

Wissam Debbah , Mezoued Mouna , Khadidja Bessaid , Azzouz Malha

Introduction: Osteoporosis is a well-recognized complication of Cushings disease (CD). It results from a combination of systemic and local effects that glucocorticoids have on bone and mineral metabolism. The prevalence of osteoporosis due to excess endogenous cortisol has been reported at 50-59%, trabecular bone is more severely affected in CS than cortical bone.Goal of the study: : To assess the prevalence of bone involvement in patients with Cus...

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ea0090p321 | Calcium and Bone | ECE2023

Severe persistent hypocalcemia and hungry bone syndrome after parathyroidectomy in a patient with giant parathyroid adenoma and concurrent osteoblastic bone metastasis from prostate cancer

Nicoleta Dumitru Alida , Sucaliuc Alina , Alexandrescu Octavian , Pena Catalina , Grigorie Daniel

Introduction: Hungry bone syndrome (HBS) is a rare condition that can appear after surgery for hyperparathyroidism, characterized by hypocalcemia, hypophosphatemia, low calciuria, especially in patients with severe primary hyperparathyroidism, bone lesions and elevated alkaline phosphatase. We present a case of severe persistent hypocalcemia after resection of a giant parathyroid adenoma in a patient with concurrent osteoblastic bone metastasis from prostate cancer.<p clas...

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ea0090p322 | Calcium and Bone | ECE2023

Clinical profile of primary hyperparathyroidism patients in a tertiary endocrine center in Kathmadu, Nepal

Joshi Ansumali , Khadka Smriti , Karmacharya Srijana , Shrestha Sushmita

There is limited data on primary hyperparathyroidism in Nepal. We did a retrospective study, where we analyzed data of sixteen patients who presented in our endocrine clinic from January 2016 to December 2022. Among them 10 patients (62.5%) were female and 6 (37.5%) were male. The mean age of the patients was 53.88 +/- 17.72 years ranging from 24 to 82 years. The mean BMI of the patients was 28.38 +/- 5.22 kg/m2. The most common presenting features were bone and joi...

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ea0090p323 | Calcium and Bone | ECE2023

Epidemiologic, clinical and biological aspects of primary hyperparathyroidism: About 107 cases

Mohamed Aghrabatt Sidi , Essabah Haraj Nassim , El Aziz Siham , Chadli Asma

Introduction: Primary hyperparathyroidism is one of the most common endocrinopathies with an estimated prevalence in the general population of 1 to 6/1000.Objective: To describe the epidemiological, clinical and biological characteristics of patients with primary hyperparathyroidism.Patients and methods: Retrospective descriptive study, including patients hospitalized in the Endocrinology Department of the Ibn Rochd University Hosp...

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ea0090p324 | Calcium and Bone | ECE2023

Non-genetic, non-pharmacologic risk factors for osteoporosis: an umbrella review of observational studies

Christou Maria , Markozannes Georgios , Christou Evangelos , Oei Ling , Tigas Stelios , Cianferotti Luisella , Goulis Dimitrios , Karasik David , Makitie Outi , Rivadeneira Fernando , Kiel Douglas , Ntzani Evangelia

Introduction: Osteoporosis is a prevalent skeletal disease associated with increased fracture risk, morbidity, and mortality. Several meta-analyses have investigated the association between non-genetic, non-pharmacologic factors and osteoporosis risk.Purpose: We aimed to perform an umbrella review of the literature to systematically evaluate the available evidence.Methods: Meta-analyses of observational studies evaluating the assoc...

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ea0090p571 | Calcium and Bone | ECE2023

Usefulness of 18F-Fluorocholine Positron Emission Tomography–Computed Tomography in locating parathyroid adenomas in primary hyperparathyroidism

Mera Carreiro Sara , Bernaldo Madrid Blanca , Avila Anton Laura , Sanchez-Maroto Garcia Noelia , Meneses Navas Maglen , Ortega Candil Aida , Pazos Guerra Mario , Espinosa De Los Monteros Patricia , Hernandez Olmeda Fernando , ochagavia camara santiago , Paz de Miguel Novoa Maria

Background: Parathyroidectomy is the only definitive treatment for primary hyperparathyroidism (PHPT). Identifying parathyroid adenomas (PA) before surgery is essential to perform minimally invasive surgery and to achieve higher cure rates.Methods: Retrospective study of patients with PHTP who underwent 18F-Fluorocholine Positron Emission Tomography- Computed Tomography (18FCH-PET-CT) between 2019 and 2021 at our center due to non-localization of PA or d...

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ea0090p572 | Calcium and Bone | ECE2023

Similarities and differences between thyroid and parathyroid nodules on ultrasound: the PARATH-US study

Yazgi Dolly , Richa Carine , Salenave Sylvie , Kamenicky Peter , Bourouina Amel , Clavier Lorraine , Young Jacques , Chanson Philippe , Maione Luigi

Context: Cervical ultrasound is a frequently used and an accessible operator-dependent tool, which contributes to the characterization of thyroid nodules and to the preoperative localization of pathological parathyroid glands. However, thyroid nodules may be confused with parathyroid lesions. There is no study directly comparing thyroid and parathyroid nodules on ultrasound.Objectives: 1) To describe the ultrasonographic characteristics of parathyroid le...

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ea0090p573 | Calcium and Bone | ECE2023

Evaluation Of Progranulin Expression in Parathyroid Adenomas and Its Relationship with Clinical Parameters

Can Uyar Bilge , Cinar Nese , Dere Yelda , Ozcan Onder , Akbaba Gulhan

Introduction: Primary hyperparathyroidism (PHPT) clinic occurs when the parathyroid glands secrete excess parathormone (PTH) due to hyperplasia, adenomatous or carcinomatous change. In the pathogenesis of the disease, dysregulation has been observed in extracellular signal-regulated 1/2 (ERK 1/2) pathways from the mitogen activated protein kinase (MAPK) family, c-Jun N-terminal kinase (JNK) pathways, and phosphatidylinositol-3 kinase (PI3K) pathways. Progranulin (PGRN) is a gl...

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ea0090p574 | Calcium and Bone | ECE2023

A long and challenging journey from the first non-typical gastrointestinal manifestations to the diagnosis of primary hyperparathyroidism and MEN 1

Kiluk Małgorzata , Łebkowska Agnieszka , Kowalska Irina , Karczewska-Kupczewska Monika

Introduction: Primary hyperparathyroidism (PHPT), as a state of chronic hypercalcemia, can be manifested by non-typical symptoms which can delay the proper diagnosis for many years and lead to serious preventable complications affecting the patients quality of life.Case report: A 52-year-old woman with hypertension, thyroid nodular goiter treated with radioactive iodine and a 20-year history of gastric and duodenal ulcerative disease, complicated b...

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ea0090p575 | Calcium and Bone | ECE2023

Cardiac MRI revealed altered structural and functional myocardium in patients with primary hyperparathyroidism: preliminary results

Ozberk Uğur , Hazirolan Tuncay , Ardali Duzgun Selin , Erbaş Tomris , Nahit Sendur Suleyman

Aim: The primary objective of this study was to evaluate the structural and functional cardiac parameters with MRI in patients with primary hyperparathyroidism (pHPT) before and after successful surgery.Method: In this prospective study 16 patients with pHPT were included. Detailed cardiac magnetic resonance imaging (MRI) examinations were performed preoperatively and at six months post-surgery. Following parameters were measured: Left ventricle ejection...

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ea0090p576 | Calcium and Bone | ECE2023

Hypercalcitoninemia in a large cohort of adult and paediatric patients with PTH-resistance syndromes

Cremaschi Arianna , Del Sindaco Giulia , Pagnano Angela , Dolci Alessia , Contarino Andrea , Ferrante Emanuele , Arosio Maura , Linglart Agnes , Mantovani Giovanna

Inactivating PTH/PTHrP signaling disorders (iPPSDs, historically named pseudohypoparathyroidism (PHP)) are a group of rare disorders associated with resistance to parathormone (PTH) and other hormones due to impaired hormonal signaling via G protein coupled receptors. Hypercalcitoninemia has been reported in these patients, however very few reports are available. The aim of this study was to further investigate the prevalence and characteristics of hypercalcitoninemia in both ...

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ea0090p577 | Calcium and Bone | ECE2023

Trabecular bone score increases the proportion of patients with asymptomatic primary hyperparathyroidism meeting surgical criteria

Malagrino Matteo , Piazza Anna , Bisceglia Nicolo , Bernardi Boari Marcello , Vandi Giulia , Altieri Paola , Pagotto Uberto , Zavatta Guido

Context: Several studies have shown that Trabecular Bone Score (TBS) predicts fractures independently of Bone Mineral Density (BMD) measured with Dual Energy X-ray Absorptiometry (DXA), even in patients with Primary Hyperparathyroidism (PHPT), known to have deteriorated bone microarchitecture. Low TBS values alone are still not considered as a single criterium to recommend parathyroid surgery. Measuring bone quality in patients with PHPT may be helpful to identify a proportion...

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ea0090p578 | Calcium and Bone | ECE2023

Assessment of dxa derived bone geometry parameters in early breast cancer patients: a cross-sectional study

Vena Walter , Pedersini Rebecca , Cosentini Deborah , Rinaudo Luca , Zamparini Manuel , Massimo Ulivieri Fabio , Mauro Pierluigi Di , Maffezzoni Filippo , Monteverdi Sara , Laini Lara , Amoroso Vito , Lucia Simoncini Edda , Farina Davide , Gerardo Lania Andre , Berruti Alfredo , Mazziotti Gherardo

Introduction: Bone mineral density (BMD) is considered a valid surrogate of bone strength in postmenopausal women, however it lacks sensitivity in individual fracture risk assessment in the setting of women with early breast cancer (EBC) patients treated with aromatase inhibitors (AIs). Indeed, mechanical resistance of bone only partially depends on bone quantity, and bone geometry and size play an important role in bone resistance to fractures. In this cross-sectional study, ...

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ea0090p579 | Calcium and Bone | ECE2023

Hyperglycemia-induced unique transcriptional changes in osteocytes

Stokar Joshua , Temkin Vladislav , Gurt Irina , Lishinsky Natan , Cox Lynne , Dresner-Pollak Rivka

Introduction: Diabetes leads to skeletal fragility and an increased fracture risk. As a master regulator of bone-remodeling, osteocyte dysfunction may play a role in the pathogenesis of diabetes-related skeletal fragility. To study the effects of hyperglycemia on the osteocyte in-isolation, we used the osteocyte-like cell line IDG-SW3 taking an unbiased multi-omics-based approach.Methods: IDG-SW3 cells were plated in a differentiation osteogenic medium u...

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ea0090p580 | Calcium and Bone | ECE2023

Low trabecular bone score better predicts prevalent vertebral fractures in younger rather than older women starting endocrine therapy for breast cancer

Malagrino Matteo , Piazza Anna , Bisceglia Nicolo , Vandi Giulia , Altieri Paola , Pagotto Uberto , Zavatta Guido

Context: Although Trabecular Bone Score (TBS) has been widely and independently associated with fragility fractures, its diagnostic power in certain populations remains to be established. Women initiating aromatase inhibitors for breast cancer should be screened for bone health to prevent cancer treatment-induced bone loss as much as possible. TBS is regarded as an adjunctive tool to evaluate these patients, but thresholds of pharmacologic interventions are still a gray zone, ...

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ea0090p581 | Calcium and Bone | ECE2023

Association Between Primary Hyperparathyroidism and Cardiovascular Outcomes: A Systematic Review and Meta-analysis

Kong Siang-Ke , Tsai Ming-Chieh , Yeh Chun-Lin , Tsai Yu-Cheng , Tsai Wen-Hsuan

Background: Parathyroid hormone excess is associated with increased risk of cardiovascular disease (CVD). The aim of the study is to evaluate the correlation between primary hyperparathyroidism (PHPT) and CVD or cardiovascular death (CV death).Method: Database research was conducted via PubMed and Embase on November 21st, 2022, with key words as following: cardiovascular disease cardiovascular death and primary hyperparathyr...

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ea0090p582 | Calcium and Bone | ECE2023

Effectiveness of Jugular Venous Sampling of Parathormone in Imaging Negative Patients with Primary Hyperparathyroidism

Sakar Kenan , Ugurlu Anil , Kapan Mehmet , Akbaba Gulhan , Cullu Nesat , Ozcan Onder , Dere Ozcan , Kandemir Ozan , Dere Yelda , Cinar Nese

Introduction: The only curative treatment of primary hyperparathyroidism (pHPT) is surgery. Accurate pre-operative localization of abnormal parathyroid glands is an essential prerequisite to reduce the complication risk associated with surgery. We aimed to determine the diagnostic value of jugular venous sampling (JVS) in cases of pHPT in which the location of parathyroid adenomas could not be determined through various preoperative imaging studies.Metho...

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ea0090p583 | Calcium and Bone | ECE2023

Impact of Zoledronate or Denosumab on Bone-related Biochemical Parameters in Osteoporotic Postmenopausal Women with Primary Hyperparathyroidism

Mlekus Kozamernik Katarina , Ležaić Luka , Hočevar Marko , Kocjan Tomaž

Introduction: Antiresorptive treatment can preserve bone mineral density (BMD) in patients with primary hyperparathyroidism (PHPT) when surgery is not feasible or desired. We aimed to compare the impact of zoledronate vs denosumab on bone-related biochemical parameters in this population.Methods: We analyzed preliminary data from our ongoing randomized trial on osteoporotic postmenopausal women with PHPT who are being treated either with zoledronate 5 mg...

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ea0090p584 | Calcium and Bone | ECE2023

Three Times Unlucky-Severe Hypercalcaemia of Immobility Compounded by Undiagnosed Hyperthyroidism and Milk Alkali Syndrome

May Rhiannon , Bujanova Jana

Background: Immobility can be associated with severe hypercalcaemia, especially when compounded by other risk factors such as concurrent hyperthyroidism and high dietary calcium/milk intake and associated complications such as renal stones and fractures.Clinical case: 59y female presented acutely with confusion, vomiting, constipation and muscle weakness. She had history of obesity, stable Crohns disease with no recent increase in colonostomy outpu...

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ea0090p585 | Calcium and Bone | ECE2023

Evidence of a non-classical phenotype of hypoparathyroidism in a cohort of adult patients with iron overload diseases

Evangelisti Selene , De Vincentis Sara , Rossi Barbara , Chiara Decaroli Maria , Locaso Michela , Ferrara Francesca , Rochira Vincenzo

Background: Iron overload disorders (IOD) are associated with a higher occurrence of unbalanced calcium (Ca)-phosphorous (P) metabolism, including hypoparathyroidism (HPT). However, data about prevalence and presentation of HPT in this setting are scanty. A Ca/P ratio <2.32 has been proposed to detect HPT in the general population.Aim: To characterize Ca-P homeostasis, particularly the prevalence of HPT, in a cohort of adult patients with IOD compare...

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ea0090p586 | Calcium and Bone | ECE2023

How well are guidelines followed in the follow-up of hypoparathyroid patients?

Turan Erdogan Beril , Keskin Caglar , Burcak Polat Şefika , Nasiroglu Imga Narin , Ozdemir Didem , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

Background: Hypoparathyroidism (HypoPT) is a rare condition that is characterized by hypocalcemia and hyperphosphatemia due to low or inappropriately normal serum levels of parathyroid hormone (PTH) for at least 6 months. The long-term complications of hypoparathyroidism indicate the necessity of screening them. In the follow-up of these patients according to hypoparathyroidism guidelines is recommended; calcium, phosphorus, albumin, magnesium, creatinine, and eGFR levels shou...

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ea0090p587 | Calcium and Bone | ECE2023

Serum Vitamin D Levels in a Group of Migraine Patients Compared With Healthy Controls: A Case–Control Study

Yarar Zeliha , Calışkan Burgucu Hatice , Altaş Mustafa , Kulaksizoglu Mustafa

Objective: Migraine is a common primary headache disorder that affects 12-15% of the general population. Also, vitamin D deficiency is a global health problem. A few studies have shown relationship between serum vitamin D levels and headache. The aim of this study was to investigate the difference in serum levels of 25-Hdroxy vitamin d [25(OH)D] between migraine patients and healthy controls and also to determine the relationship of vitamin D deficiency with frequency and seve...

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ea0090p588 | Calcium and Bone | ECE2023

Vitamin D deficiency persists despite rising use of vitamin D supplements in Western Greece

Zoupas Ioannis , Bantouna Dimitra , Livadas Sarantis , Angelopoulos Nicholas , Jaume Juan C , Karvounis Evaggelos , Imam Shanawaz , Paparodis Rodis

Introduction: Use of supplements (VDS) and vitamin-D measurements have been rising in the recent past globally. Despite increasing intake, our observations reveal that a large percentage of the population remains deficient (VDD). We designed the present real-world study, to address this controversy.Methods: We collected data from patients attending our clinics between March 2014 and December 2022. We recorded our subjects gender, age, history of VD...

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ea0090p589 | Calcium and Bone | ECE2023

Denosumab for Osteoporosis in Patients With Primary Hyperparathyroidism in a Tertiary Hospital in Spain

Alexandra Zapata Maldonado Gabriela , Isla Alberto , Piedra Maria , Ramos Ramos Laura , Vazquez Luis

Introduction: Osteoporosis is a frequent complication associated with primary hyperparathyroidism (PHPT), and surgery is the most effective treatment once established. However, many patients are not candidates for it, and different medical options have been investigated. We aimed to assess the efficacy of denosumab (DMAB) in increasing bone mineral density (BMD) and preventing PHPT-related complications.Methods: Case-control study defining cases (Group 1...

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ea0090p590 | Calcium and Bone | ECE2023

Post-thyroidectomy development of posterior reversible encephalopathy syndrome (PRES) due to over-replacement of hypocalcemia

Papalou Olga , Katechakis Nikolaos , Koukoula Chrysoula , Beka Aikaterini , Baikousi Dimitra , Gkoufa Kyriaki , Mandrapylia Angeliki , Stratigou Theodora , Vassiliadi Dimitra , Tsagarakis Stylianos

A 61-year-old woman was admitted to the Emergency Department with generalized seizures. She reported general malaise, anorexia, headache and multiple episodes of vomiting that started about 12 h before admission. She had a history of recent thyroidectomy, and she was on oral calcium carbonate (3 gr/day) and alpha calcidol (3 mg/day). Non-contrast head CT scan was negative for major findings. Laboratory work up revealed hypercalcemia (corrected calcium 14,4 mg/dl), renal impair...

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ea0090p591 | Calcium and Bone | ECE2023

Abstract withdrawn...

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ea0090p592 | Calcium and Bone | ECE2023

Clinical Features of Patients with Primary Hyperparathyroidism in Mugla: A Single-Center Experience

Sakar Kenan , Ugurlu Anil , Taskiran Uyar Irmak , Akbaba Gulhan , Kirli Ismail , Cullu Nesat , Ozcan Onder , Dere Ozcan , Kandemir Ozan , Dere Yelda , Cinar Nese

Introduction: Primary hyperparathyroidism (pHPT) is the third most frequently seen endocrine disease with autonomous overproduction of parathyroid hormone (PTH) in one or more parathyroid glands. Its associated with osteoporosis, bone fractures, nephrolithiasis, renal failure and increased cardiovascular risk. We aimed to investigate the distribution of the clinical manifestations and biochemical features in patients with pHPT.Methods: A retrospect...

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ea0090p593 | Calcium and Bone | ECE2023

Densitometry misinterpretation leading to unnecessary denosumab prescription

Hrabar Mirna , Andrić Jelena , Šamle Ivona , Pandžić Jakšić Vlatka

Background: Bone mineral density (BMD) measurement is an important tool for fracture risk assessment, but should be used with awareness of its performance and analysis pitfalls.Case Presentation: A 59-year-old patient underwent her first densitometry as part of a routine medical check-up. She had no previous fractures and no risk factors that could impair bone health. The results showed that her BMD was in the range of low bone mass. Four years later, de...

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ea0090p594 | Calcium and Bone | ECE2023

The clinical and etiological aspects of primary hyperparathyroidism

Myriam Baltagi , Najla Bchir , Hadj Sliman Chayma Bel , benchhida annam , Chadia Zouaoui , Ouertani Haroun

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by inappropriate secretion of parathyroid hormone leading to hypercalcemia. The aim of our study is to evaluate the clinical and etiological aspects of PHPT in our series.Methods: This is a retrospective descriptive study including 32 patients followed for PHPT at the endocrinology department of the military hospital of Tunisia between January 2018 and December ...

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ea0090p595 | Calcium and Bone | ECE2023

Therapeutic and evolutive aspects of primary hyperparathyroidism

Chayma Bel Hadj Sliman , Najla Bchir , Myriam Baltagi , Benchhida Annam , Chadia Zouaoui , Ouertani Haroun

Introduction: Surgery is the only curative treatment for primary hyperparathyroidism (PHPT). However, some patients may present a persistence or a recurrence after surgical treatment. The aim of our study was to evaluate the therapeutic and evolutive aspects of PHPT after the first surgery.Methods: A retrospective study was conducted at the endocrinology department of military hospital of Tunis including 32 patients diagnosed with PHPT over a period of f...

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ea0090p596 | Calcium and Bone | ECE2023

Surgery of primary hyperparathyroidism during pregnancy: case series

Libansky Petr , Fialova Martina , Jezkova Jana , Kosak Mikulas , Matejkova Behanova Magdalena , Moravcova Jitka , Vcelak Josef , Vaculova Marketa , Lischke Robert

Background: Primary hyperparathyroidism can occur at any age, the typical patient is a postmenopausal woman, primary hyperparathyroidsim is found rare by pregnant women. The maternal symptoms are similar to the symptoms by postmenopausal women.Materials and methods: Among the years 2000-2022 we have performed 3459 operations (including 6,6% reoperations) with diagnosis of hyperparathyroidism, there were six women, who underwent parathyroidectomy during p...

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ea0090p597 | Calcium and Bone | ECE2023

Better late than never - a very rare cause of short stature

Dorogi Carmen , Corlan Ana-Silvia , Golu Ioana , Daniela Toma Andreea , Vlad Mihaela

Introduction: X-linked hypophosphatemic rickets (XLH) is a very rare cause of growth deficiency that can be diagnosed even in adulthood. The mutation of the PHEX gene in these patients causes higher levels of FGF-23 and hypophosphatemia.Case presentation: A 20-year-old male patient was admitted into our clinic due to short stature, walking difficulties, joint and muscle pain, predominantly in the lower limbs. He described the presence of symptoms since c...

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25th European Congress of Endocrinology

BiosciAbstracts