Endocrine Abstracts

Introduction: Tight metabolic control reduces the risk of microvascular complications in individuals with type 1 diabetes (T1DM). Multiple studies have shown improvements in quality of life (QOL) in children following the introduction of continuous subcutaneous insulin infusion (CSII) but metabolic outcomes have been more variable. This audit looked at metabolic parameters at long-term follow up in children and adolescents using CSII over 3 years.Methods...

Aim: To investigate the glycaemic control of patients with T1DM before and after the introduction of CSII therapy.Methods: All patients with T1DM receiving CSII therapy for more than 6 months attending the Children’s University Hospital from 2005–2011 were included. Glycosylated haemoglobin (HbA1c) was recorded 12 and 6 months prior to starting therapy, at the time of CSII initiation and annually thereafter. Adverse events and BMI were also rec...

Aim: Our previous studies indicated the potential antidiabetic actions of the amphibian host-defence peptide, tigerinin-1. Tigerinin-1R was conjugated with gastric inhibitory polypeptide (GIP) as part of strategies for further development of its therapeutic effects. This study characterises the insulin-releasing and cytotoxic properties of the resulting hybrid peptide.Method: Pure G-TGN was commercially synthesized G-TGN. Insulin releasing effects were a...

Introduction: Perioperative mortality of patients who undergo heart valve surgery for carcinoid heart valve disease (CHVD) has been observed to be high (5–10%). We investigated whether peptide receptor radiotherapy (PRRT) with Lutetium-177 Dotatate can be used safely in patients with neuroendocrine neoplasms (NEN) and CHVD and if there is an associated survival advantage by reducing overall exposure of the valves to high doses of vasoactive peptides.<p class="abstext"...

There is limited research into the impact of active brown adipose tissue (aBAT) in patients with phaeochromocytomas and paragangliomas (PPGLs). A small body of evidence has shown that patients with PPGL patients can exhibit a high prevalence for aBAT recognized as ranging between 8 - 28% without specific correlation to germline mutations. Furthermore, it has been suggested that aBAT may be linked to increased mortality. Systematic searches of the Medical Literature Analysis an...

Introduction: Interpretation of renal function in patients with obesity and post-bariatric surgery is a clinical challenge. EGFR could be falsely low and weight loss does not reflect muscle mass. The aim of our study was to compare the fluctuations in renal function assessment in patients undergoing bariatric surgery.Methods: 200 patients who underwent bypass surgery or sleeve gastrectomy were analysed. Six different renal function parameters were analys...