Endocrine Abstracts

Introduction: Tubulin is a multifunctional cytoskeletal protein involved in key cellular processes, including cell movement, intracellular transport and mitosis. An increased expression of βIII-tubulin (TUBB3) has been observed in several cancer types and associated with aggressive and drug refractory disease.Expression of claudins (CLDNs), the main component of tight junctions, is frequently altered in human cancers, including papillary thyroid car...

Introduction: Human leukocyte antigen-G (HLA-G) is a non-classical HLA-class Ib molecule with multiple immunoregulatory properties. Its main role is the maintenance of tolerance between maternal immune system and semiallogenic fetus. The expression of HLA-G antigen has been reported in several cancers and seems to play an important role in the escape of tumour cells from immune surveillance. A 14 bp insertion/deletion polymorphism in exon 8 of the 3′ untranslated region ...

Background: Radioiodine (131I) therapy is performed in patients with differentiated thyroid cancer (DTC), either for thyroid remnant ablation or treating distant metastasis. Although 131I therapy is generally considered safe, a genotoxic damage has been demonstrated both in vivo and in vitro.Aim: To evaluate the possible effect of Ginkgo biloba extract (EGb 761) supplementation on the time-course (up to 1...

The long-term risk of carcinogenic and genetic damage following the treatment with 131I for differentiated thyroid cancer (DTC) is quite low. The hypothyroid status (HS), at the time of 131I administration, decreases the renal clearance of 131I and increases the whole-body, blood and bone marrow irradiation, unlike the euthyroid status (ES). Chromosome aberrations (CA) in peripheral lymphocytes reflect blood cells exposure to irradiation. This ...