Endocrine Abstracts

Case history: We present a 40 year old female admitted with hyperglycaemia, polyuria, polydipsia and weight loss of 6 kg over a 1 month period. She had no night sweats or change in bowel habit. There was no personal or family history of malignancy or diabetes mellitus. She denied any alcohol, cigarette or illicit drug use. She took no prescription or OTC medication. On examination, she was jaundiced with pale mucous membranes. The rest of systemic examination was normal. Capil...

The utility of renin measurement in guiding mineralocorticoid replacement is unclear. To address this we retrospectively examined the parameters and treatment of 97 patients with Addison’s disease over a five year period.Methods: Adrenal replacement, blood pressure (BP), orthostatic BP response, urea, sodium, potassium and renin levels of 97 patients attending our clinic were collected over the period 2012–2016. Data ...

Introduction: Nephrolithiasis and osteoporosis are more common in people with primary hyperparathyroidism (PHPT), although the clinical factors associated with this risk are not well characterised. Recent evidence has suggested parathyroid hormone concentration, but not calcium, is associated with mortality in PHPT.Methods: Retrospective analysis of all patients presenting to the Edinburgh Centre for Endocrinology & Diabetes wi...

Introduction: The performance of biochemical and imaging investigations in contributing towards successful surgical outcomes is not well characterised in PHPT.Methods: Retrospective analysis of all patients presenting to the Edinburgh Centre for Endocrinology & Diabetes with PHPT between 2006 and 2014 (n = 611). Parathyroid surgery was performed in 44.8%.Results: PTH was greater than 2x ULN in 34...

Introduction: Radioiodine (RAI) is safe and effective but further information to predict outcomes, specifically treatment failure and residual symptoms following treatment of hypothyroidism, may help improve outcomes.Methods: Retrospective, observational, single-centre study. Electronic medical record review (n= 664) and patient questionnaire (n= 174).Results: Complete cohort: Analysis of outcomes li...

The utility of renin measurement in guiding mineralocorticoid replacement is unclear. To address this we retrospectively examined the parameters and treatment of 97 patients with Addison’s disease over a five year period.Methods: Adrenal replacement, blood pressure (BP), orthostatic BP response, urea, sodium, potassium and renin levels of 97 patients attending our clinic were collected over the period 2012–2016. Data ...

Introduction: Nephrolithiasis and osteoporosis are more common in people with primary hyperparathyroidism (PHPT), although the clinical factors associated with this risk are not well characterised. Recent evidence has suggested parathyroid hormone concentration, but not calcium, is associated with mortality in PHPT.Methods: Retrospective analysis of all patients presenting to the Edinburgh Centre for Endocrinology & Diabetes wi...

Introduction: The performance of biochemical and imaging investigations in contributing towards successful surgical outcomes is not well characterised in PHPT.Methods: Retrospective analysis of all patients presenting to the Edinburgh Centre for Endocrinology & Diabetes with PHPT between 2006 and 2014 (n = 611). Parathyroid surgery was performed in 44.8%.Results: PTH was greater than 2x ULN in 34...

Introduction: Radioiodine (RAI) is safe and effective but further information to predict outcomes, specifically treatment failure and residual symptoms following treatment of hypothyroidism, may help improve outcomes.Methods: Retrospective, observational, single-centre study. Electronic medical record review (n= 664) and patient questionnaire (n= 174).Results: Complete cohort: Analysis of outcomes li...

Asfotase alfa (AA, STRENSIQ, Alexion Pharmaceuticals, Inc.) is the first FDA-Approved treatment for patients with hypophosphatasia, the result of a mutation in the tissue-nonspecific alkaline phosphatase (ALPL) gene. Because it contains the ALP active site, AA is able to catalyse the substrate as the antibody-conjugated ALP would within an assay. Therefore, AA present in a patient’s sample may generate a false positive or a false negative result. We investigated ...