Searchable abstracts of presentations at key conferences in endocrinology

ea0011p28 | Bone | ECE2006

Evidence for high prevalence of hormonal irregularities in male osteoporosis

Goebel S , Riegel C , Seefried L , Saller B , Jakob F

Introduction: Osteoporosis in males is an underdiagnosed condition. It is considered to be of secondary pathogenesis in up to 60% of cases. In order to establish rational flow charts for the diagnosis and management of osteoporosis in men solid data seem to be necessary about the incidence of certain underlying diseases.Methods: In a prospective screening for hormonal alterations we analysed 65 patients with male osteoporosis according to laboratory para...

ea0035oc1.4 | Thyroid clinical | ECE2014

Consequences of experimental hyperthyroidism on brain structure and function in humans

Dirk Anna-Luise , Goebel Anna , Heldmann Marcus , Iwen Alexander , Brabant Georg , Munte Thomas

Objective: Disturbed levels of thyroid hormones are associated with neuropsychiatric disorders, including memory impairments. Even short-term hyperthyroidism may affect properties of the human brain. To investigate the influence of thyroid hormones, we conducted functional neuroimaging. The aim of this study was to evaluate functional changes in working memory performance.Materials and Methods: Twenty healthy, male, right-handed subjects (age range 21&#1...

ea0049ep1445 | Thyroid (non-cancer) | ECE2017

Theranostic management of medullary thyroid cancer (MTC) with (111In/177Lu) CP04: how close are we to a clinical solution?

Hubalewska-Dydejczyk Alicja , Erba Paola , Decristoforo Clemens , Zaletel Katja , Mikolajczak Renata , Maecke Helmut , Maina-Nock Theodosia , Konijnenberg Mark , Kolenc-Peitl Petra , Trofimiuk-Muldner Malgorzata , Przybylik-Mazurek Elwira , Virgolini Irene , Pawlak Dariusz , de Jong Marion , Froberg Alide C , Rangger Christine , Goebel Georg , Scarpa Lorenza , Skorkiewicz Konrad , Lezaic Luka , Garnuszek Pirotr , Sowa-Staszczak Anna , Nock Berthold A , Bergant Damijan , Rep Sebastijan , Glowa Boguslaw

Effective targeted therapy for advanced endocrine malignancies is a goal of modern endocrinology. We herein present promising results of the first phase of clinical part of European project (Gran-T-MTC) aimed to assess the safety of gastrin analogue CP04 (DOTA-(DGlu)6-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2) i.v. administration in dose (50 μg) useful for translation to 177In-CP04 for PRRT. CP04 has been selected for MTC therapy based on a high CCK-2 receptor...