Endocrine Abstracts

Case history: A 28-year-old gentleman was referred with symptoms of memory fog, difficulty with concentration, mood disturbance and fatigue. His thyroid function tests had been stable but abnormal for over 8 years, with a normal FT4 between 17–19 pmol/l (12–22 pmol/l), FT3 5.6 pmol/l (3.1–6.8 pmol/l) and an elevated TSH between 12–16 mu/l (0.27–4.2 mu/l). He had no family history of thyroid disease. He was clinically euthyroid. His weight had remained ...

Introduction: Hyponatraemia, defined as serum sodium <135 mmol/l is one of the commonest electrolyte abnormalities seen in patients admitted to acute hospitals and is associated with increased morbidity and mortality. Impact of this condition is not adequately measured in critically ill patients admitted to intensive care unit. The aim of this observational study was to assess the incidence and outcomes of patients admitted to intensive care unit (ICU) in a UK based settin...

Introduction: Vitamin D deficiency/insufficiency in patients with primary hyperparathyroidism may be associated with more severe and progressive disease. In such patients there is higher levels of parathormone and markers of bone turnover, large parathyroid adenomas and more frequent fractures than vitamin D replete patients.Aims and objectives: To determine whether vitamin D repletion of patients with PHPT and co-existing vitamin D insufficiency or defi...

Retrospective audit of Patients had Parathyroidectomy over 2 years in East Sussex NHS trust; 73 patients had Parathyroid surgery for Primary hyperparathyroidism during this period. We have collected the data using case notes and hospital electronic records. Fifty-six patients were females and 17 were Males. Ninety-three per cent of patients were more than 50 years old. Common presenting symptoms were Lethargy (51%), bone pain (44%) and other symptoms were polyuria, polydipsia....

Objective: We studied the prevalence of endocrine dysfunction in subjects with idiopathic Parkinson’s disease (IPD) on newer dopaminergic agents (DA). DA are used in endocrine hypersecretory states in small doses and we hypothesized that endocrine dysfunction was likely in IPD where DA was used in comparatively much higher dosage.Patients and methods: 25 subjects with IPD on DA for were recruited to this cross-sectional study. We measured IGF1, prol...

Introduction Lithium (Li) is an effective treatment for bipolar and schizo-affective disorders. It has a narrow therapeutic index, and produces common side effects when this is exceeded. Li causes endocrine disruption by predictable and some hitherto unclear mechanisms. We present a subject who developed multiple Li induced endocrinopathies concurrently, and was a therapeutic challenge. Case presentation and investigations Mr. DM had been on Li for 10 years and developed polyu...

A 45-year-old man presented with sudden onset left sided pleuritic chest pain and breathlessness. He was hypotensive and severely hypoxic and was admitted to the Intensive Care Unit. A chest X-ray was normal and an urgent computerised tomographic (CT) pulmonary angiogram showed the presence of extensive pulmonary emboli. The CT scan also showed bilateral adrenal “incidentalomas” with the right one being 8 cm and the left 6 cm in its longest dimension. He responded we...

Case: A 43-year-old Caucasian lady presented with an acutely painful, cold left leg to the vascular surgeons. She was being treated for respiratory tract infection in the community. She has been investigated for palpitations 7 years ago with no cause identified and headache 3 years ago with normal CT head. Her peripheral vascular examination was unremarkable, including a normal ankle brachial pressure index. She was admitted for further investigations to rule out an underlying...