Endocrine Abstracts

Objective: Androgen may be detrimental in the development of coronary artery disease (CAD) in women. We investigated possible associations between the (TAAAA)n polymorphism of sex hormone binding globulin (SHBG) gene promoter, which influences transcriptional efficiency of the SHBG gene and the severity of CAD in women.Methods: One hundred and twenty women (37–82 yrs), undergoing coronary angiography. CAD severity, history of angina, myocardial infa...

Impaired estrogen (E2) action is important for cardiovascular disease (CAD) in both men and women. Associations of CAD with estrogen receptor polymorphisms, which may influence sensitivity to E2 have been reported for men but have not been confirmed for women. The aim of the present study was to investigate the association of estrogen receptor common polymorphisms with the severity of coronary disease in women undergoing coronary angiography.Estrogen rec...