Endocrine Abstracts

RT-coding genes are expressed at very low levels in differentiated, non pathological tissues, while are significantly up-regulated in undifferentiated and transformed cells, suggesting a direct correlation between the level of expression of RT and the proliferative state of the cell. Either nevirapine and efavirenz, two RT inhibitors, used in the therapy of AIDS, reversibly down-regulate cell proliferation and induce differentiation in several human tumor cell lines.<p cla...

Background: Well-differentiated neuroendocrine tumors (NETs) are characterized by the overexpression of somatostatin receptors (SSTRs). To efficiently engage and activate tumor infiltrating lymphocytes against NET cells, we designed a novel bispecific T-cells engager (BiTE) composed of 2 molecules of somatostatin-14 (SST14), the hormone that physiologically binds SSTRs, linked with a single chain variable fragment (scFV)-based anti-CD3.Methods: The optim...

Introduction: Non-functioning (NF), sporadic and MEN1 associated, G1-G2 pancreatic neuroendocrine tumors (PanNETs) usually display an indolent course. Surgery is the first-choice treatment for localized tumors >2 cm. Unresectable or metastatic PanNETs expressing somatostatin receptors (SSTRs) are treated with somatostatin analogs (SSAs). The standard treatment for patients with PanNETs ≤ 2 cm is active surveillance (AS). Yet no evidence of the value of SSA treatment ...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominantly inherited endocrine tumor syndrome characterized by development of cancer in various endocrine organs, particularly in pituitary, parathyroid and pancreas. Moreover, in some cases, also non-endocrine tumors can be diagnosed, developing atypical phenotypes.Case report: We report herein the clinical history of a patient affected by MEN-1 syndrome who developed atypical feat...