Endocrine Abstracts

Introduction: We present a case of Dunnigan Kobberling type of lipodystrophy in a young female.Case report: A 25-year-old woman presented with hirsuitism, secondary amenorrhoea, increase in neck size and reduction in breast size. On examination she had moon like facies, broad neck, small breasts and well defined male pattern musculature. Testosterone and lutenising hormone were marginally raised, serum alanine transminase was raised. Overnight dexamethas...

Introduction: Riedel's thyroiditis is a rare chronic inflammatory disease of the thyroid characterised by an invasive fibrotic process.Case report: A 48-year old lady with newly diagnosed profound hypothyroidism was started on thyroxine and referred due to a rapidly enlarging goitre. Examination revealed a hard fixed goitre in an euthyroid patient. Thyroglobulin (titre 1: 10,000) and thyroid peroxidase (titre 1: 100,000) antibodies were strongly positiv...

Background and aims: Cardiovascular (CVS) disease accounts for the majority of morbidity and mortality in diabetes. We audited lipid management in a hospital diabetes clinic.Patients: CVS disease risk factors were assessed in 241 consecutive patients with diabetes (type1 15%, type2 85%, male 53%, female 47%, mean age 59±13 years, mean duration of diabetes 10±9 years). 86(36%) had symptomatic atherosclerotic vascular disease (secondary prev...

: A 67-year-old lady, previously fit and well, presented with chest pain. She denied gastrointestinal or urological symptoms. There was no history of depression, psychosis, previous hip fracture or steroid use. She had regular menstrual cycles until hysterectomy at 50 years of age. She doesn’t smoke or drink alcohol. Her mother and father had oesophageal and lung cancer respectively with no family history of hypercalcemia. On examination, she was normotensive with BMI 23....

: A 67-year-old lady, previously fit and well, presented with chest pain. She denied gastrointestinal or urological symptoms. There was no history of depression, psychosis, previous hip fracture or steroid use. She had regular menstrual cycles until hysterectomy at 50 years of age. She doesn’t smoke or drink alcohol. Her mother and father had oesophageal and lung cancer respectively with no family history of hypercalcemia. On examination, she was normotensive with BMI 23....

64 y/o male was being investigated for raised PSA. Following an MRI and biopsy, he was diagnosed with high grade prostatic intraepithelial neoplasia requiring close PSA surveillance. Incidentally, he was found to have bilateral adrenal lesions, measuring 6.4 cm on the left and 4 cm on the right. Prior to review in endocrine clinic, adrenal workup and CT adrenals were performed. CT showed both adrenal masses contain fat and calcification and are thought to be bilateral adrenal ...

Introduction: Adrenal Incidentalomas (AI) are frequently encountered in clinical practice with radiological studies suggesting a frequency of 3% at 50 years rising to 10% in elderly. Majority of AI are non functional adenomas with malignant lesions quoted as less than 20% at most. We report a case of AI, which was found to a Melanoma on biopsy with no other primary site.Case: An 84 year old gentleman was found to have a right suprarenal mass on ultrasoun...

Introduction: Metastatic lesion in the pituitary is a rare condition with most of them being asymptomatic. Breast cancer is the most frequent primary location and the overall prognosis is poor. We describe the case of a lady with this condition, who presented to our unit with bitemporal hemianopia.Case: A 65 year old lady with history of breast cancer (surgical excision with chemoradiotherapy 4 years ago, HER2 negative, currently in remission) presented ...

Introduction: Orthostatic hypertension (OHT) is a phenomenon which may represent increased cardiovascular risk and is less well recognized compared to orthostatic hypotension.Case: A 65 year old gentleman presented with symptoms of lethargy and episodic shaking. He has a history of treated prostate cancer and was not on any regular medications. He noticed consistently elevated blood pressure on standing during home monitoring. His lying BP was 142/82 and...

A 26-year-old female presented with 5-year history of episodic muscle weakness, abdominal cramps and facial paresthesia. She had 2 hospital admissions elsewhere within 6months with severe hypokalaemia (1.9 mmol/L). She was started on Lamotrigine for epilepsy 7 years ago and changed to Levetiracetam in October 2010 following further seizures. She is now seizure-free for over 5 years. Her potassium levels before and after Levetiracetam are shown in Table 1.<table boarder="1"...