Endocrine Abstracts

Objectives: GH measurements during OGTT have profound effects on therapy and follow-up management of acromegaly. To minimize the discordance between immunoassays, it is recommended to calibrate them using 22 kDa-GH-preparation instead of the use of pituitary-derived calibrants. The aim of our study was to evaluate the between-method discrepancies in GH determinations by assays using different calibrants considering further confounders like age, gender, and BMI.<p class="ab...

Objectives: Besides the measurement of IGF-1, GH suppression during OGTT to assess the biochemical status in acromegaly is recommended. However, as a consequence of the development of highly sensitive and specific GH assays a critical re-evaluation of the criteria for the diagnosis and follow-up management of acromegaly is mandatory. The aim of our study was to evaluate the between-method discrepancies in GH determinations by different immunoassays considering further confound...

Objectives: Insulin resistance (IR) and obesity are very common metabolic abnormalities, which are often associated with reduced GH secretion. GH reduces intraabdominal fat and its deficiency may contribute to the metabolic syndrome. IGF-1 improves IR but IGFBPs have a potential role in regulating its bioactivity although only little information exists. We postulate that the elevated insulin levels in IR may persistently suppress GH provided its regulation remains insulin sens...