Endocrine Abstracts

Summary: The autoimmune polyglandular syndromes (APS) comprise a wide spectrum of autoimmune disorders and are divided into a very rare juvenile (APS 1) and a relatively common adult type with (APS 2) or without adrenal failure (APS 3). APS 1 is caused by mutations in the autoimmune regulatory (AIRE) gene on chromosome 21 and is inherited in an autosomal recessive manner. Mutations of the AIRE gene result in defective proteins which cause autoimmune destruction of target organ...

Papillary thyroid cancer (PTC) is the most common endocrine malignancy. The survival rate is excellent, however in some cases it transforms to dedifferentiated invasive tumor. Tumor cell invasion and metastasis are major causes of cancer mortality. It is a challenging task to identify critical genes controlling metastatic potential and disease recurrance. We sought molecular prognostic markers that could improve diagnostics and planning therapy.Comparati...

Introduction: In acromegaly GH excess leads to impaired insulin sensitivity with an alteration of beta-cell function. The consequent hyperglycemia leads to a further increased cardiovascular risk and mortality.Case report: A 16 years old patient was first referred to the Department of Pediatrics in 2014 with accentuated growth since the age of 10. The reason of the first referral was a sport injury (head trauma during playing basketball). Sella MRI depic...