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ea0081oc2.2 | Oral Communications 2: Adrenal and Cardiovascular Endocrinology 1 | ECE2022

Loss of SUMO-specific protease 2 leads to adrenal insufficiency limited to glucocorticoids

Dufour Damien , Dumontet Typhanie , Sahut-Barnola Isabelle , Onzon Meline , Pussard Eric , Wilmouth Jr James , Olabe Julie , Levasseur Adrien , Bossis Guillaume , Yeh Edward , Val Pierre , Martinez Antoine , Anne-Marie Lefrancois-Martinez

The adrenal gland produces corticosteroids essential for hydromineral and metabolic homeostasis. It is organised, in mice, in two concentric layers. The zona glomerulosa (zG) and fasciculate (zF), renewed from progenitors located in the capsular periphery. Centripetal renewal and maintenance of cortical zonation are dependant of a balance between WNT/β-catenin and ACTH/PKA signalling pathways. They provide recruitment and consecutive differentiation of progenitors into zG...

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ea0050p330 | Obesity and Metabolism | SFEBES2017

Blunt response to a stress test and higher prevalence of risk polymorphism of glucocorticoid receptor gene (NC3C1) in obese patients

de Gortari Patricia , Valdes Mariana , Camarena Beatriz , Hernandez-Munoz Sandra , Falcon Elena

Chronically exposure to stress promotes in individuals high intake of foods with high content of carbohydrates and fat and may develop obesity. Stress-induced sustained elevation of glucocorticoid serum levels may be due to impaired functioning of the hypothalamic glucocorticoid receptor GR, altering the hypothalamic-pituitary-adrenal axis regulation. As a result, chronically stressed individuals are unable to respond with higher cortisol levels wh...

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ea0050p330 | Obesity and Metabolism | SFEBES2017

Blunt response to a stress test and higher prevalence of risk polymorphism of glucocorticoid receptor gene (NC3C1) in obese patients

de Gortari Patricia , Valdes Mariana , Camarena Beatriz , Hernandez-Munoz Sandra , Falcon Elena

Chronically exposure to stress promotes in individuals high intake of foods with high content of carbohydrates and fat and may develop obesity. Stress-induced sustained elevation of glucocorticoid serum levels may be due to impaired functioning of the hypothalamic glucocorticoid receptor GR, altering the hypothalamic-pituitary-adrenal axis regulation. As a result, chronically stressed individuals are unable to respond with higher cortisol levels wh...

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Endocrine Abstracts

Loss of SUMO-specific protease 2 leads to adrenal insufficiency limited to glucocorticoids

Blunt response to a stress test and higher prevalence of risk polymorphism of glucocorticoid receptor gene (NC3C1) in obese patients

Blunt response to a stress test and higher prevalence of risk polymorphism of glucocorticoid receptor gene (NC3C1) in obese patients

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