Endocrine Abstracts

Introduction: The global patterns of aberrant DNA methylation in thyroid cancer are not known. In this study, we have used DNA methylation arrays to determine, for the first time, the genome-wide promoter methylation status of different subtypes of thyroid tumors.Material and methods: We analyzed a cohort of 54 snap frozen thyroid samples (thirteen papillary tumors, six follicular, eleven anaplastic, twenty medullar and four normal tissue samples). Also ...

Aim: Obesity represents a risk factor for the development of type 2 diabetes mellitus (T2DM). Although, this seems to reflect common environmental and genetic factors underlying both pathologies, the link between these conditions is not so clear. A diverse group of elements, including miRNAs, has been implicated in the development of these two metabolic diseases. miRNAs are involved in complex regulatory networks of gene expression. This suggests that alterations in ...