Endocrine Abstracts

The pulse mode of gonadotrophin-releasing hormone (GnRH) release from the hypothalamus and following luteinising hormone (LH) pulses from the pituitary induce follicular development in female animals. Kisspeptin neurons in the hypothalamic arcuate nucleus (ARC) are suggested to be the GnRH pulse generator. Adrenomedullin (AM) is a secretory peptide expressed in various tissues, including the hypothalamic paraventricular nucleus, but its functions in the central regulation of r...

Delayed puberty (DP) is traditionally defined as the absence of testicular enlargement by the age of 14 years in boys and absence of breast development by 13 years in girls (1). In both sexes, DP is most frequently caused by constitutional delay of growth and puberty (CDGP), which represents a late variant of the normal timing of puberty (1-3). Other possible causes for DP include permanent hypogonadotropic hypogonadism (HH), functional hypogonadotropic hypogonadism and hyperg...