Endocrine Abstracts

Hyponatraemia is common in acute medical admissions, to district general hospitals presenting with neurological complications and increasing length of stay. We have carried out an audit against the following standards: full drug history; assessment of volume status; paired plasma and urinary osmolalities; appropriate fluid and Na+ management and monitoring; and target Na+>125 mmol/l on discharge.Fifty two patients with hyponatra...

Reactive hypoglycaemia is usually mild, often presents with non-specific symptoms and may be difficult to distinguish from neuropsychiatric illnessThe diagnosis should be considered when these symptoms are related to eating. We present a severe case of idiopathic hypoglycaemia which responded dramatically to the alpha-glucosidase inhibitor acarbose.A 25 year old woman presented with a nine year history of intermittent thirst, feeling hot, distal paraesth...

A 54yr old female presented with a 12-month history of tremor, sweating, anxiety and occasional palpitations. There was no past medical or family history of note. On examination, she had a fine tremor but no neck masses or eye signs. Her FT4 20.8 pmol/l (8pmol/l-22pmol/l), FT3 7.3 pmol/l (3.5-6.5pmol/l) with a suppressed TSH less than 0.01mu/l (0.35mu/l-5.5mu/l); 99Tc scan showed an autonomous hot nodule in the right lower lobe of the thyroid with partial suppression of the re...

Background: Risperidone is a widely used antipsychotic, known to cause secondary hyperprolactinaemia. Hyperprolactinaemia is associated with erectile dysfunction, amenorrhea and reduced bone mineral density (BMD). However, there is insufficient information about the extent, severity and association between these side effects, particularly among the south Indian population.Aim and objectives: To estimate the prevalence of erectile dysfunction and amenorrh...

Introduction: There are many reports describing the association of alternations of bone and mineral metabolism in patients with epilepsy receiving long term anticonvulsant therapy. However, there are only a few Indian studies which have looked at this aspect. Objective: This study was done to compare the prevalence of changes in bone mineral parameters and bone mineral density (BMD) in ambulant individuals on long term anticonvulsant therapy with age and BMI matched healthy co...

AZP-3601, a long-acting PTH/PTHrP(1-36) analog, is a candidate new treatment option for hypoparathyroidism (HP). As compared to conventional PTH(1-34), AZP-3601 binds with higher affinity to the R0 conformation of the PTH-1 receptor, resulting in prolonged signaling and sustained elevations in blood calcium (Ca++) in vivo, despite a very short circulating half-life. We assessed whether repeated injection of AZP-3601 into TPTX rats at doses aimed to normalize serum C...

We report a case of two incidental lesions, a benign adrenal schwannoma and cerebral meningioma. There are no cases in the literature to link de-novo adrenal schwannoma and meningioma in patients. This case highlights the importance of multidisciplinary working to ensure expedited management in such cases.A 76 year old gentleman presented to ED with a seizure and a community-acquired pneumonia. Past medical history included atr...

We report a case of two incidental lesions, a benign adrenal schwannoma and cerebral meningioma. There are no cases in the literature to link de-novo adrenal schwannoma and meningioma in patients. This case highlights the importance of multidisciplinary working to ensure expedited management in such cases.A 76 year old gentleman presented to ED with a seizure and a community-acquired pneumonia. Past medical history included atr...

Case history: Our patient is a 64 year old lady who had bilateral adrenalectomy in 1978 for Cushing”s disease. This was followed by radiotherapy in late 1978. To get further reduction of the ACTH producing pituitary adenoma she had transsphenoidal surgery in 1979 and then transfrontal craniotomy in 1982. This was followed by further radiotherapy in 1985. It left her with panhypopituitarism and she was on full hormone replacement. She presented to our hospital in late 2008...

Case history: 73-year-old woman recently commenced on oral diuretics for peripheral oedema was admitted with severe hypokalaemia and refractory hypertension. Conn’s syndrome was initially considered but admission of regular liquorice consumption made a diagnosis of hypokalaemic hypertension (pseudoaldosteronism) secondary to liquorice over-indulgence more likely. She went on to develop cardiomyopathy and had haematemesis from a bleeding duodenal ulcer (DU). Endocrine test...