Endocrine Abstracts

Introduction: Total daily insulin required to achieve glycaemic control in type 1 diabetes (T1D) depends on numerous factors. Correlation of insulin requirement to BMI and waist circumference has been variably reported in the literature, whilst that of WHtR has not been studied.Aims: To study the correlation between daily insulin requirement (TDD) and WHtR in a multi-ethnic population.Methods: A cross-sectional study of children (5...

Introduction: Several studies have described ethnic differences in HbA1c. Non-Caucasian patients have been found to have a higher HbA1c than the Caucasian ones. These differences have often been attributed to disparities in access to medical care or quality of the care. However differences in HbA1C in ethnic minorities could also relate to biological factors so we looked at mean levels of glycaemia. The aim of our study was to observe if there is a similar correlation between ...

Background: Over-dosing and under-dosing of vitamin D in children and young people appears to be common, based on our audit of current practice. The contribution of ethnicity, skin colour, and vitamin D binding protein (VDBP) genotype has not been fully explored during vitamin D treatment.Objective: To investigate how ethnicity/skin colour and genetic variation affect the response to 150 000 units of vitamin D administered to young adults of white Caucas...

Background: Pediatric patients with diabetes are required to adhere to strict regimens including blood glucose testing, insulin therapy, and dietary restrictions. Adequate glucose control is necessary to prevent acute and chronic complications. Testing Hemoglobin A1c (HgbA1c) provides a simple evaluation of diabetes control and compliance with therapy. Psychological factors (depression, anxiety) play a major role in pediatric diabetes compliance. Access to psychological suppor...

Background: There is uncertainty as to whether glucocorticoid receptor (GCR) polymorphisms play a role in the development of glucocorticoid-related side-effects in individuals receiving hydrocortisone replacement for Addison’s disease.Method: One-hundred-and-forty-seven Addison’s patients were age, gender, ethnicity and body mass index (BMI) matched with 147 control subjects. Genotyping was performed using polymerase chain reaction (PCR) for th...

Cushing’s syndrome (CS) is a rare but severe disease associated with an increased mortality especially due to cardiovascular diseases, and associated with various systemic complications, including hypertension, glucose intolerance or diabetes mellitus, dyslipidemia and coagulopathy. Few studies have systematically evaluated the mortality of CS in a large and worldwide population of CS. The MISSION study is a retrospective study aimed at assessing the mortality in a large ...

Objectives: Limited evidence exists studying the impact of ethnicity on diabetic ketoacidosis (DKA). We aimed to study the impact of ethnicity on presentation, management and outcome of DKA in type 1 (T1DM) and type 2 (T2DM) diabetes.Methods: All DKA episodes from April 2014 to September 2020 in a UK tertiary care centre were identified. Data were collected on diabetes type, demographics, biochemical and clinical features on admission, and DKA management...

Background: More than 12,000 people are diagnosed with neuroendocrine malignancies each year in the US. There are limited data on YO-NETs/YO-NECs. In the present study, we seek to evaluate clinical characteristics/trends of patients with GI-YO-NETs and GI-YO-NECs.Methods: Using the National Cancer DataBase, NCDB, we identified 124,081 GI-NETs and 52,063 GI-NEC cases 18 or older, diagnosed between 2004 and 2019. Histology codes to identify NETs and NECs w...