Endocrine Abstracts

Background: Hyponatraemia is known to be associated with significantly increased mortality in hospitalised patients. We identified the number of cases of hyponatraemia referred for an endocrine opinion in our hospital, examined the causes present, and assessed how the speed of referral to endocrinology could affect the management. Methods: Inpatient referrals were audited over a 6-month period from 1st October 2021 to 30th April 2022. Data regarding the ...

Introduction: In April 2019 a team of healthcare professionals took a group of young people with type 1 Diabetes to Botswana for a healthcare partnership project with Diabetes Botswana. The trip included a joint diabetes youth camp and the delivery of Botswana’s first ever Diabetes Educational Symposium.Objectives: The primary aim of the project was to provide a reciprocal learning experience for the management of type 1 diabetes for healthcare prof...

Objective: Clinical and histopathological assessment of a consecutive series of Munich patients operated between 2016 and 2018 for unilateral primary aldosteronism (PA).Background: Unilateral PA is the most common surgically curable form of hypertension mainly caused by an aldosterone-producing adenomas (APA). Somatic mutations in KCNJ5, CACNA1D, ATP1A1 or ATP2B3drive the aldosterone excess in the majority of APAs. Genetic variants in <...

Introduction: Children with type 1 diabetes mellitus are at increased risk of autoimmune thyroid and coeliac disease. Reported prevalence figures for thyroid and coeliac disease in this population has been reported in European studies as 3–8%1 and 1–10%2 respectively. Current NICE guidelines (June 2009) recommend screening for both conditions at diagnosis, and then screening annually for thyroid disease thereafter. We aimed to: i) estimate preva...

Hyperthyroid cats have elevated parathyroid hormone (PTH) concentrations and suppressed fibroblast growth factor-23 (FGF-23) concentrations, both of which normalise following treatment of hyperthyroidism. PTH, FGF-23, and thyroid hormone can influence the renal reabsorption of calcium and phosphate. The aim of the present study was to assess the influence of hyperthyroidism on renal tubular function in cats indirectly, by comparing the FE of electrolytes in hyperthyroid cats w...

Hungry bone syndrome is common in tertiary hyperparathyroidism after parathyroidectomy. Less frequently, it has been described after thyroidectomy in patients with hyperthyroidism. We hereby report a case of hungry bone syndrome in a patient who suffers with Graves’ disease.A 44-year-old woman with a history of refractory Graves’ disease presented with 4 weeks history of shortness of breath, palpitations and peri-oral paraesthesia following tot...

T3 regulates bone development and its actions are mediated by TRα and TRβ. Using TR knockout mice we demonstrated that TRα1 is the predominant mediator of T3 action in bone, although TRα2 (a non-T3 binding isoform of unknown function) and TRβ1 are also expressed in the skeleton. We show that mice lacking TRα2 have characteristic skeletal abnormalities of delayed closure of the skull sutures, abnormal clavicle development and reduced bone mineraliz...

Annexin 1 (ANXA1) externalised from folliculostellate cells is known to be an essential intermediate in the early delayed (30 min- 3 h) negative feedback of glucocorticoids on the release of ACTH and other pituitary hormones. We have used a well-characterised folliculostellate cell line (TtT/GF cells) to investigate the mechanism by which ANXA1, a cytoplasmic protein, is externalised by cells. Externalisation is stimulated by dexamethasone (Dex) and inhibited by inhibitors of ...

A 26-year-old woman presented with vomiting and cortical blindness. CT scan of the brain confirmed a right-sided parietal-occipital infarct, She subsequently developed seizures and neurological extension resulting in global dysphasia. Serum and CSF lactate were elevated (4.4 and 4.3 mmol/l respectively, NR<1.8). MELAS syndrome was confirmed by mitochondrial DNA analysis, which revealed an A3243G mutation in muscle and serum (85% muscle, 63% urinary epithelial cells and 33%...

Thyroid Eye Disease (TED) is an autoimmune inflammatory condition of the orbit occurring in the setting of thyroid disease. Prevention of the distressing physical and psychological sequelae of TED depends on accurate quantification of disease activity to allow selection of the most appropriate treatment modality. Current practice is based on the use of a Clinical Activity Score (CAS). As an alternative approach, and with the potential benefits of reproducibility and ease of us...