Endocrine Abstracts

Patients with Cushing's disease have high levels of circulating corticosteroids. Treatment may result in unmasking of steroid dependant conditions. We report a case of ulcerative colitis presenting after bilateral adrenalectomy.Case reportA 19 year old girl underwent bilateral adrenalectomy in November 1998 for pituitary dependant Cushing's disease. She was discharged on hydrocortisone and fludrocortisone and post operatively her c...

Case: A GP with autoimmune hypothyroidism presented with a phaeochromocytoma during labour at the age of 36 y. A left adrenalectomy confirmed the diagnosis and a basal cell carcinoma was also removed. She had a history of Dupuytren's lesions of both soles and palms starting in her teenage years and multiple keratosis. There was no family history of any endocrine or skin disorder. At 41y, a benign breast lump was removed and also a gastrointestinal spindle cell stromal tumour (...

Case: A GP with autoimmune hypothyroidism presented with a phaeochromocytoma during labour at the age of 36 y. A left adrenalectomy confirmed the diagnosis and a basal cell carcinoma was also removed. She had a history of Dupuytren's lesions of both soles and palms starting in her teenage years and multiple keratosis. There was no family history of any endocrine or skin disorder. At 41y, a benign breast lump was removed and also a gastrointestinal spindle cell stromal tumour (...

Section 1: Case history: We present the case of a 35-year-old gentleman referred by his GP to Endocrinology clinic for loss of libido and testosterone deficiency. His co-morbidities included obesity (BMI 59 kg/m2), hypertension and obstructive sleep apnoea (OSA) requiring overnight continuous positive airways pressure (CPAP) therapy. Routine pituitary profile showed luteinising hormone 4.8 IU/l (1–8), testosterone 7.1 nmol/l (8–25), prolactin 232 mU/l (86&...

A 34-year old lady presented in the postpartum period following her 3rd pregnancy with severe hypertension. Her first two pregnancies were 3 and 5 years previously where she delivered via elective Caesarean section without any complications. During this pregnancy which was a twin pregnancy, her antenatal care was mainly unremarkable but on specific questioning, she reported increased sweating for a period of 4 months. Her blood pressure was noted to be normal during her antena...

Introduction: Hormone-secreting teratomas are well described. However teratomas secreting pancreatic hormones are rare, with even fewer cases producing clinically significant effects. We describe possibly the first documented case of hyperinsulinaemic hypoglycaemia due to an insulin-secreting ovarian teratoma.Case report: A 23-year-old woman presented with transient symptoms of lethargy and weakness. She had used her father’s capillary glucose meter...

Case history: We present the case of a 40-year-old man who was referred to a cardiologist with hypertension. He was initiated on bisoprolol and doxazosin. Investigations revealed elevated urinary metanephrines and catecholamines, with normetadrenaline 7.4 μmol/24 h (normal <2), noradrenaline 820 nmol/24 h (normal <500) but normal dopamine levels. He was referred to our clinic. Two further 24 h urine catecholamine assays were elevated. Dexamethasone suppression tes...

Introduction: Palpable thyroid nodules have a prevalence of 4–7%, which increases with imaging. About 5% are malignant. Efficient management is essential. USG and FNAC are valuable in assessing and preventing unnecessary thyroidectomies. Objective To compare our practice with local and Royal College of Pathologists guidelines. Methods All thyroid nodule patients seen in clinic between April to September 2010 were included. Data collected included age, gender, TFT, thyroid...

We describe our patient, a 50 year old lady who developed Addisons disease 10 years ago with typical signs and symptoms of weight loss, hyperpigmentation, tiredness and postural hypotension. She is under follow up at our clinic for last 4 years. Her identical twin was diagnosed with Addisons disease and hypothyroidism at age 27 and with Coeliac disease when she was 43. Both of them are positive for anti-adrenal and TPO antibodies.Our patient developed le...

We present the case of a Caucasian girl who in 1991 at the age of 4 started virilising and was diagnosed to have 21-hydroxylase deficiency. She started her periods at 10 and has been under regular follow up. In 2004 she underwent vaginoplasty and clitoral reduction and made good recovery. She has been stable on hydrocortisone 10 mg in the morning, 12.5 mg in the evening and fludrocortisone 50 mcg once daily (Testosterone<0.7 mmol/l (0.5–3.0), 17-hydroxy progesterone=1...