Endocrine Abstracts

Introduction: A woman’s iodine requirements increase substantially during pregnancy to ensure adequate supply to both mother and fetus. The deficiency of this element may cause several maternal-fetal repercussions. For this reason, iodine supplementation for pregnancy has been recommended and the World Health Organization (WHO) commends an iodine urinary concentration at a median UIC 150–249 μg/l. As in many other countries around the world, there is evidence of...

The ingestion of high-fat diet has been considered a crucial factor in the genesis of subclinical systemic inflammation and insulin resistance. The resistance training (RTr) can be an effective tool for the prevention and treatment of immune-metabolic disorders through physiological and morphological adaptations. The purpose of the present study was to analyze the effects of RTr and cessation of training on muscle inflammation and expression of genes related to glucose metabol...

Introduction: Acromegaly is a chronic disease caused by growth hormone (GH) oversecretion. A pituitary macroadenoma is found in mostly of cases, but the secretion pattern of GH and insulin-like growth factor 1 (IGF-1) and the natural history of somatotropinomas are heterogeneous. The objective of the present study was to evaluate the relationship between tumor size, GH and IGF-1 levels in patients diagnosed with acromegaly.Methods: A cross-sectional, obs...

Introduction: In most cases, adrenal masses are non-functioning adrenocortical adenomas. On ‘Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline’ published in 2016, the experts ‘suggest against repeated hormonal work-up in patients with a normal hormonal work-up at initial evaluation unless new clinical signs of endocrine activity appear or there is worsening of comorbidities’.C...

Introduction: Hypoparathyroidism is characterized by hypocalcemia and low or inappropriately normal levels of PTH. The most common cause of hypoparathyroidism is iatrogenic due to anterior neck surgery. In recent years it was documented that vitamin D insufficiency is widespread.Aim: To investigate the cause of hypocalcemia in thyroidectomized patients with PTH within the reference range.Methods: Retrospective review of clinical re...

Introduction: Treatment of hyperthyroidism in older adults is crucial to reduce its morbidity and mortality. Radioactive iodine has been widely used in this age group due to its efficacy, safety and cost-effectiveness.Aim: To determine the efficacy of 131I for treatment of hyperthyroidism in the elderly.Methods: Retrospective study of 86 hyperthyroid patients aged ≥65 years who performed radioiodine therapy. We eva...

Cushing disease is defined by signs and simptoms of hypercortisolism due to augmented ACTH secretion from pituitary origin. It is very rare in pediatric age, with general incidence around 13 cases/1 000 000 persons/year.Case description: S.G.N, male, 14.5 years old, was brought for medical attention due to weight gain and weakness in the last 4 months. At physical examination, he presented with moon face, cervical acanthosis nigricans, hypertrichosis and...

Introduction: Pendred syndrome is a rare autosomal recessive disease and the classic triad is congenital sensorineural hearing impairment, goiter and impaired iodine organification with abnormal perchlorate discharge test, but hypothalamic tumors are not a feature of this syndrome.Case report: We report a case of a 32-year-old female with Pendred syndrome confirmed by genetic testing and perchlorate discharge test, with goiter, hypothyroidism treated wit...

Introduction: Radiodine (131I) is widely used in the treatment of patients with thyroid cancer. This therapy is associated with some adverse effects including possible impairment of ovarian function and earlier menopause.Objective: The aim of this study was to evaluate female fertility after treatment with 131I of differentiated thyroid cancer (DTC).Methods: We retrospectively analysed 250 women with DTC treat...

Introduction: Liquid silicone is an inert material that as minimal local tissue reaction, but it is the systemic complications, such as silicone embolism and acute respiratory distress syndrome (ARDS) that carry the highest associated morbidity. Liquid silicone is frequently used for illegal cosmetic procedures in transsexual patients, and the most common injection sites are the hips, buttocks, face and breasts.We report a case of silicone embolism with ...