Endocrine Abstracts

Objectives: To assess the androgens profile (total testosterone (TT),free testosterone (fT), SHBG, and DHEA-sulphate), cortisol, aldosterone, insulin, and leptin in patients with obesity (OB), metabolic syndrome (MS) and healthy men (HM).Subjects and methods: Group 1: 26 men with obesity, age 30±6 years. BMI 27–35 kg/m2. Group 2: 34 men with MS, age 31±6 yrs. BMI 30–36 kg/m2. Group 3: 20 healthy men, age 28±...

Background: It is known women suffer from macroprolactinaemia more frequently than men. Often men with unclear genesis of hyperprolactinaemia have normal or a little depressed Testosterone level. High macroprolactin level in blood serum can explain this type of hyperprolactinaemia.Materials and methods: Sixty-four men with hyperprolactinaemia (Prl >600 mU/l) were studied. Clinical, biochemical and MRI methods were used. Prl and Testosterone levels we...

Recently, the phenomenon of macroprolactinaemia has manifested itself into a great interest for physicians. This problem forces both physicians and patient to waste sizeable resources, and can lead to iatrogenic and unjustified emotional stress and further material losses. At the same time the problem of differential diagnostics of pseudoprolactinomas and true prolactinomas remains challenging. The purpose of the present study was to determine the clinic-analytical repercussio...

Hypoestrogenemia is associated with dislipidemia and is an independent risk factor for cardiovascular diseases in postmenopausal women. However, there is a cohort of young women with gonadal steroid deficit caused by the disorders of central regulation. Twenty women with hypogonadotropic hypogonadism (HH) were included in group 1. (median age - 29 years and 3 months, median duration of amenorhea - 5 years 3 months, mean BMI - 24.6±6.05 kg/cm2. Women were examined before a...

Objectives: To assess prevalence of antipsychotic-induced hyperpolactinemia (AIH) in psychiatric in-patients and to describe its clinical characteristics and association of AIH with sexual function.Methods: A cross-sectional study in 143 consecutive psychiatric in-patients (F/M=65/78), mostly with schizophrenia (93%), currently taking antipsychotics. The patients were screened for serum prolactin, sex hormones, gonadotropin levels and macroprolactin. For...

We examined 56 normoprolactinemic women of reproductive age (18–45 y.o.) with isolated hypogonadotropic hypogonadism (group 1) initially and on treatment with 2 mg of 17β-estradiol and 10 mg of dydrogesterone in sequenced manner (HRT), duration of HRT was from 18 to 42 (median 36) months; 45 healthy women (20–38 y.o.) were included in control group 2.Initially hypercholesterolemia was observed in 50% of cases in group 1 and 6.6% in group 2...

It is known that a subset of obese individuals do not exhibit features of the metabolic syndrome (Met-S); these are referred to as being metabolically healthy obese (MHO) individuals. Conversely there are other individuals who although have a normal BMI are insulin resistant and exhibit some of the features of the Met-S and are termed as being metabolically unhealthy normal weight (MUHNW) individuals. This study aims to identify the prevalence of metabolic health among a diffe...

Elevated macroprolactin level is one of the reason of misdiagnosis and mismanagement of hyperprolactinamia. About 10% of population have incidentalomas and it also can combine with increasing of prolactin (Prl).Three hundred and thirty patients with hyperprolactinemia (Prl>600 mU/l) were studied: 192 women and 138 men in age of 30 (25; 39) and 35 (29;46) years respectively. Clinical, biochemical and MRI methods were used. Prl, LH, FSH and Testosteron...

Germline mutations in the aryl hydrocarbon receptor interacting protein gene (AIP) predispose to pituitary adenomas in young patients, often presenting as familial isolated pituitary adenoma (FIPA) kindreds. Pituitary adenomas in patients with AIP mutations (AIPmut) are usually somatotropinomas, which are more aggressive and have poorer responses to somatostatin analogues than their non-mutated counterparts. Given the rarity of this condition, the molecular pathogenesis of the...

Introduction: We report the clinical presentation of pheochromocytoma with Cushing’s syndrome due to ectopic production of ACTH, and assess the histopathological diagnosis, treatment modality and prognostic factors compared with the literature.Results: Cushing’s Syndrome due to ectopic ACTH production is uncommon and due to pheochromocytoma is extremely rare. We discuss the case of a 50-year-old female who initially presented with vague, non-sp...