Endocrine Abstracts

Background: Maternal free testosterone (FT) increases during 3rd trimester pregnancy and FT levels are higher in women with polycystic ovary syndrome (PCOS) compared to controls. Fetal exposure to maternal FT during 3rd trimester was associated with lower weight, length and shorter abdominal circumference at birth, in boys. Furthermore, lower birth weight has been related to higher abdominal fat mass in young children.Aim: To examine associations between...

Background: Prolactin is associated with metabolic risk inside and outside of pregnancy. Maternal prolactin levels could be associated with offspring body composition.Aim: To investigate if maternal prolactin-levels were linked to offspring body composition at seven years of age.Design: Prospective observational cohort study (the Odense Child Cohort).Methods: Maternal fasting blood samples were assessed durin...

Computed Tomography (CT) constitutes the basic technique for imaging of adrenal tumours and neuroendocrine tumours (NETs). The major work-load in adrenal imaging is characterisation of adrenal incidentalomas, i.e. adrenal tumours diagnosed on imaging performed for other reasons than adrenal disease. Myelolipomas, which have a typical appearance with areas of macroscopic fat, and simple cysts are easy to characterize and require no follow-up. Morphologically benign adrenal tumo...

Puberty marks the transition period from childhood into adulthood with the attainment of adult reproductive capacity. Timing of puberty exhibit marked interindividual variation and depends on genetic and lifestyle factors. Onset of puberty has started earlier during the last 20 years, which cannot be attributed to genetic factors. Thus, lifestyle and environmental factors must be responsible for these worrying trends....

Computed tomography (CT) is the basic method for morphological imaging of neuroendocrine tumours (NETs) for visualization of local tumour extent and staging of regional and distant metastases. Magnetic resonance imaging (MRI) and intravenously contrast-enhanced ultrasound (CEUS) are complementary methods but are less frequently available and are therefore predominately used when CT does not suffice. This, however, varies depending on the local situation and expertise. Endoscop...

Klinefelter syndrome (KS) which affects 1–2- per 1000 males, is not only challenging for the patients and their families. Professionals, who manage KS patients need a much better scientific foundation for decision making in patient care. Surprisingly little research on how to manage boys, adolescents and men with KS has been carried out in comparison to management of other clinical problems like, e.g. Turner syndrome. One of the problems has been that management, which mu...

Klinefelter syndrome (KS) is the most common sex chromosome disorder affecting 1:600 men.We know from previous clinical and epidemiological studies that men suffering from KS have an increased risk of diabetes and an increased risk of dying from diabetes, but the reasons for the increased risk are unknown.Seventy KS patients and 71 age-matched men participated in a study on body composition, measures of sex hormones, insulin sensit...

Glucocorticoids act via the glucocorticoid receptor (GR). Upon ligand binding, GR translocates to the nucleus and binds directly to glucocorticoid responsive elements (GREs) to regulate transcriptional output. Glucocorticoid secretion increases in response to stress to affect transcriptional output within specific areas of the brain including the hippocampus (HC). Therefore, here we assess changes in genome-wide GR chromatin binding profiles in the rat HC in response to a gluc...

Background and aim: Patients with GH deficiency (GHD) have increased risk of cerebrovascular events. The aim of this study was to evaluate the rate and factors associated with the occurrence of stroke, a major cause of death and disability, in adults with GHD.Patients and methods: Data from 15,188 GHD patients treated with GH replacement therapy (GHRT) enrolled in KIMS were analyzed. Stroke incidence rates were compared to rates from the Oxford Vascular ...

Introduction: Patients planned for first time surgery for clinically non-functioning pituitary adenoma (NFPA) were included in this prospective study.Aims: – To study the prevalence of hypothalamic-pituitary-adrenal (HPA) axis failure preoperatively and 3 months after surgery for clinically NFPA.– To investigate factors predicting risk of HPA axis failure postoperatively.Hypotheses<p class="abst...