Endocrine Abstracts

Introduction: Amiodarone is an anti-arrhythmic drug rich in iodine compounds. One 200 mg tablet corresponds to about 25 times the daily requirement of iodine. One of the major complications of taking Amiodarone is the development of dysthyroidism which is observed in 15% to 20% of cases. Hyperthyroidism occurs in 1 and 13% of these patients.Case report: We report the case of an 34 year old female patient, followed for complete arrhythmia by atrial fibril...

Background: Diabetic ketoacidosis (DKA) is the most serious acute metabolic complications of diabetes. Unfortunately, there is a dearth of published data on this entity from Egypt. The aim of our work was to determine the clinical characteristics, precipitating causes and mortality rate of patients with diabetic ketoacidosis in National Institute of Diabetes and Endocrinology.Methods: Our work is a retrospective study in which we reviewed and analyzed th...

Background: Current criteria for the diagnosis of diabetic ketoacidosis (DKA) are limited by their nonspecificity (serum bicarbonate [HCO3] and pH) and qualitative nature (the presence of ketonemia/ketonuria). A new method is now available to measure capillary levels of beta-hydroxybutyrate (beta -0HB), It is a quantitative and enzymatic test that uses the same equipment as for home capillary blood glucose determination but with specific strips. Aim of the work: The aim of thi...

Obesity is a major risk factor for chronic non communicable diseases and plays a central role in the insulin resistance or metabolic syndrome, which includes hyperinsulinemia, hypertension, hyperlipidemia, type 2 diabetes mellitus, and an increased risk of adult onset obesity and atherosclerotic cardiovascular disease (1). Insulin resistance is a state in which a given concentration of insulin produces a less than expected biological effect. The metabolic syndrome is a cluster...

Thyroid hormones disturbances may lead to glucose metabolism abnormalities but little is known about the risk of hyperglycaemia in hypothyroidism.The aim of our study is to determine the frequency and the predisposing factors to hyperglycaemia in hypothyroidism.Subjects and methods: It is a retro and prospective study including 425 hypothyroid subjects (383 F/42 M). We search for hyperglycaemia which means fasting glycaemia ≥...

Autoimmune thyroiditis (AIT) is a group of inflammatory thyroid disorders with either hyperthyroid, euthyroid or hypothyroid state. The aim of this study is to detect the subclinical thyroiditis among the Egyptians type 1 diabetic patients and to study the relation of the thyroid antibodies to different metabolic control indices of diabetes. The study group consisted of 50 type 1 diabetic patients aged from 8 to 18 years. They were selected from the out-patient daily clinics o...

Type 1 diabetes is a chronic autoimmune disease with a subclinical prodromal period characterized by the presence of circulating antibodies to various islet cell proteins. Our main objective is to estimate the prevalence of diabetes-associated autoantibodies in a group of 1st degree relatives, compared to healthy control subjects. Also, we tried to assess the insulin secretory capacity in subjects having multiple antibodies using first phase insulin response (FPIR) to intraven...

Introduction: Blood groups and the Rh factor are involved in several pathologies. Some studies have also identified them as risk factors for diabetes. The objective of this work is to evaluate the possible association between ABO blood groups, rhesus (Positive, Negative) and the risk of diabetes.Patients and methods: This is a case-control study involving 257 diabetic patients followed in the hygiene department and 266 controls followed at Sidi Othmane H...

Introduction: Obesity is a risk factor for cardiovascular disease and diabetes. The objective of this work is to study the prevalence of obesity among a consultant population at the Hygiene Service of the Sidi-Othman District (ASO) in Casablanca.Patients and methods: This is a case-control study of subjects consulting the Sidi Othmane hygiene service. Socio demographic, anthropometric data (weight, height, waist circumference, hip circumference, body mas...

Introduction: Mast cells are critical effectors in inflammatory diseases, including cardiovascular and metabolic diseases and their associated complications. These cells exert their physiological and pathological activities by releasing granules containing histamine, cytokines, chemokines, and proteases, including mast cell-specific chymases and tryptases.Aim of the study: To detect the role of mast cell in diabetic obese and correlation to different dia...