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Endocrine Abstracts (2019) 63 P157 | DOI: 10.1530/endoabs.63.P157

Diabetes, Obesity and Metabolism 1

Relationship study between blood groups, rhesus factor and the risk of diabetes type 2 in a population of the Sidi Othmane district, Casablanca

Fatima Zahra Kehailou1, Houriya Mestaghanmi1, Mohammed Jabari2, Ali Labriji3, Souad Amrani4 & Ahmed Dibane5


1Laboratory of Pathophysiology and Molecular Genetics, Team of Metabolism Nutrition Toxicologie, Ben M’Sik Faculty of Sciences, Hassan II University of Casablanca, Casablanca, Morocco; 2Hygiene Service of the District of Sidi-Athmane, Casablanca, Morocco; 3Laboratory Modelisation Analysis and Simulation, Department of Computer Mathematics, Ben M’Sik Faculty of Sciences, Hassan II University of Casablanca, Casablanca, Morocco; 4Laboratory of Ecology and Environment, Faculty of Sciences Ben M’Sik, University Hassan II-Casablanca, Casablanca, Morocco; 5Sidi Othmane Hospital, Casablanca, Morocco.

Introduction: Blood groups and the Rh factor are involved in several pathologies. Some studies have also identified them as risk factors for diabetes. The objective of this work is to evaluate the possible association between ABO blood groups, rhesus (Positive, Negative) and the risk of diabetes.

Patients and methods: This is a case-control study involving 257 diabetic patients followed in the hygiene department and 266 controls followed at Sidi Othmane Hospital. Blood groups were taken from medical records and blood glucose was determined. Statistical analysis is performed using SPSS software 23.

Results: 523 subjects were included in this study, of whom 71.2% are women and 28.8% are men with an average age of 50.62±14.93. The mean fasting blood glucose level was 1.57±0.78 in diabetic subjects and 1.01±0.11 g/l in controls. The distribution frequency of group O in the population is 45.5%, while that of non-O (A, B and AB) is 54.5% with (31.4% of group A, 5% of the AB group and 16.6% of the B group). The distribution of ABO blood groups in diabetics by sex (women vs men) is respectively A (73.3% vs 26.7%), AB (81.2% vs 18.8%), B (83, 8% vs. 16.2%) and O (82.2% and 17.8%). On the other hand, among controls, it is 65.2% vs 34.8% for group A, 77.8% vs 22.2% for AB, 78% vs 22% for B and 51.4% and 48.8%, 6%) for O. 94.4% of the control population and 91.1% of the diabetic population consisted of Rh+. Analysis of the association between diabetes and blood group O and non-O revealed a low but significant correlation (r=0.093, P=0.034, OR =1.452, CI =1.027–2.051), with an effect protective agent for blood group O (OR =0.861, CI =0.676–0.986) and a pejorative effect for non-O blood groups (OR =1.185, CI =1.185–1.388) and with a significant difference by female gender. In addition, no association was observed between diabetes and Rhesus factor (P=0.098).

Conclusion: Our study showed a slight association between blood group O and the risk of diabetes probably related to the female sex. Further studies are needed to support it.

Keywords: ABO blood groups, Rhesus, diabetes

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

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