Endocrine Abstracts

We have previously attributed the hypoglycaemic effects of Syzygium cordatum leaf extract to crude ethyl acetate extract solubles (EAS) containing triterpenoid compounds. The present study was designed to isolate and characterize triterpene components EAS and investigate the antihyperglycaemic effects alone or in combination with insulin in non-diabetic and streptozotocin (STZ)-induced diabetic rats. EAS soluble extracts were obtained after defatting the S. cordatum<...

Previous studies from our laboratories indicate that the anti-diabetic effects of Syzygium cordatum (Hochst.) (Myrtaceae) leaf extract in streptozotocin-induced diabetic rats may be attributed in part to mixtures of triterpenes, oleanolic acid (OA) and ursolic acid (UA). For the bioactive compounds to have potential in diabetes management, they should also alleviate or prevent complications of diabetes mellitus; kidney function and cardiovascular disorders. This study i...

Background: Some regrowing nodules after radiofrequency ablation (RFA) of symptomatic large benign thyroid nodules are revealed as malignancies in surgery. The aim of the study was to assess the ultrasound (US) characteristic of thyroid nodules diagnosed as cancer later, the predictive factors for cancer after RFA, and the prevention methods for these cancers to avoid RFA.Materials and Methods: The medical records of 22 thyroid nodules with 18 patients w...

Background and aims: Type 1 diabetes mellitus (T1DM) results from a severe autoimmune destruction of pancreatic beta cells, which renders patients insulin-dependent for life. The triggering of autoimmunity against beta cells is caused by a complex interaction between environmental, genetic and epigenetic risk factors. Although significant progress has been made in elucidating the genetic factors associated with T1DM, the non-genetic components have remained poorly understood. ...

Circadian rhythms in behaviours and gene expression are driven by the autonomously rhythmic cells of the hypothalamic suprachiasmatic nucleus (SCN). In nocturnal rodents, restricting a daily meal to the lights-on phase, leads to entrainment of behaviour and gene expression in many extra-SCN hypothalamic nuclei and peripheral tissues. This anticipatory activity is independent of the SCN and is likely to arise from the activities of multiple hypothalamic centres including the do...

Introduction: The majority of current guidelines recommend surgery for benign solid nodules with pressure symptoms or a significant growth. Currently, minimal invasive techniques have emerged such as radiofrequency ablation (RF) which achieve significant volume decrease and many cases, the improvement or disappearance of pressure symptoms.Results: We describe the efficacy and safety of one single-session of RF in our centre performed in thyroid nodules f...

Background: The aim of this study was to assess health-related quality of life (HRQoL) of patients living in cities and towns with different population in the Russian Federation (RF) using EQ-5D questionnaire, to calculate health utility index (QALY) and cost-utility ratio (CUR).Methods: One of the goals of the multicenter, observational, epidemiologic study FORSIGHT-DM2 was to evaluate HRQoL using the EQ-5D Questionnaire. The study included more than 20...

Male infertility arises as a global public health in the context of the dramatic decrease in birth rates. However, the underlying causes of male infertility remain unknown in many cases. An increasing number of studies suggest that environmental and behavioral factors (smoking, drinking, etc) may affect the hormone levels and other pathways involved in male fertility. The aim of this study was to investigate the influence of various environmental factors and hormonal profiles ...

Determination of radiochemical purity (RCP) of radiopharmaceuticals based on 68Ga-BCA-peptides (68Ga-DOTA-TOC/-TATE, 68Ga-NODAGA-RGD2, 68Ga-PSMA-HBED-CC, etc.) is an extremely important part of QC in routine clinical practice. Nature of gallium leads to formation of two major radiochemical impurities in the radiopharmaceutical: hydrolyzed 68Ga (colloid) and unbounded ionic forms of 68Ga. The amounts o...

Background: In the last decades mini-invasive techniques have been proposed to reduce costs and complications of emithyroidectomy and thyroidectomy, both for benign nodular goiter and thyroid microcarcinoma, and image-guided laser and radiofrequency ablation are the most used.Purpose: To investigate short and long-term efficacy of image-guided laser and radiofrequency ablation as therapy options for benign nodular goiter.Methods: F...