Endocrine Abstracts

Background: By regulating the concentration of active estrogens in tumor cells, steroid hormone-inactivating estrogen sulfotransferase (SULT1E1) and estrogen activating steroid sulfatase (STS) may influence the progression of EOC. Therefore, we determined the expression and prognostic impact of both enzymes together with the ERα/β and the progesterone receptor (PGR) in this tumor entity.Methods: The mRNA expression levels of STS, SULT1E1, ER&#9...

Introduction: In 1960, Van Wyk and Grumbach described the association of hypothyroidism and precocious puberty. Hypothyroidism leads to delayed bone age and a reduction in growth rate by reducing the amplitude of GH pulses. When precocious puberty is associated with thyroid hypofunction, estrogen action on the epiphyseal plates reduce this delay. We report the case of a child who developed incomplete puberty and reduced growth rate, caused by primary hypothyroidism.<p clas...

Introduction: Several studies identified pre-treatment parameters that could help in the prediction of the thyroid functional outcome after radioactive iodine therapy (RAI) in Graves’ disease. However, the role of the thyroid peroxidase antibody (TPO Ab) status is not well studied.Objectives: We investigated if a positive TPO Ab status before radioactive iodine (RAI) therapy in patients with Graves’ hyperthyroidism is a predictive factor for de...

Objective: We investigated if a positive thyroid peroxidase antibody (TPO Ab) status before radioactive iodine (RAI) therapy in patients with Graves’ hyperthyroidism is a predictive factor for developing hypothyroidism after RAI.Methods: We performed a retrospective study of patients with Graves’ hyperthyroidism with known TPO Ab status, receiving a first administration of RAI. Patients from 4 thyroid outpatient centres in Belgium receiving a f...

Introduction: Van Wyk-Grumbach syndrome was first described in 1960 in patients presenting with long standing juvenile hypothyroidism, delayed bone age and precocious puberty. Literature review indicates only few cases reported in males compared to females. We are reporting this case in a male patient who presented with short stature.Case: A 7.25-year-old boy was referred for endocrine opinion due to short stature. He had not grown over the last 18 month...

Introduction: Children with long-standing primary hypothyroidism usually have growth retardation, neurodevelopmental impairment, and delayed puberty. However, paradoxical precocious puberty, namely Van Wyk-Grumbach syndrome (VWGS), has been described. The postulated mechanism is high levels of TSH stimulate gonadal FSH receptors, resulting in ovarian over-stimulation and precocious puberty. Since the enlarged ovarian cyst is commonly found in VWGS, malignancy is often suspecte...

Introduction: Precocious puberty occurs is associated with initial increase in linear growth and acceleration of bone maturity presenting as advanced bone age with early epiphyseal fusion which ultimately results in short stature. ‘Van Wyk Grumbach Syndrome’ (VWGS) is a rare syndrome associated with incomplete isosexual precocious puberty and macroadenoma seen in cases of longstanding, untreated hypothyroidism is associated with a delayed bone age. Complete resolutio...

Aims: To identify factors associated with early postpartum weight retention (PPWR) in women with recent gestational diabetes mellitus (GDM).Methods: Multicentric prospective study in women with a recent history of GDM based on the IADPSG criteria at the oral glucose tolerance test (OGTT) 6-16 weeks postpartum. Data obtained from electronic medical records, self-administered questionnaires, clinical examination and blood sample collection were used for th...

Aims: To determine predictors of neonatal adiposity and differences in associations by fetal sex in women with gestational diabetes mellitus (GDM), normal-weight and overweight (BMI ≥ 25 kg/m²) normal glucose tolerant women (NGT).Methods: Skinfold thickness was measured in 576 newborns, and cord blood leptin, c-peptide and lipids in 327 newborns in a multi-centric prospective cohort study.Results: Compared to ...

Aim: To determine the association between thyroid function and the risk for gestational diabetes mellitus (GDM) and adverse pregnancy outcomes.Methods: This case-control study was a sub-analysis of the BEDIP-N study, in which 199 GDM women were matched for age and body mass index with 398 controls. Thyroid stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3), and thyroid peroxidase (TPO) antibodies were measured at 6-14 weeks and ...