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Endocrine Abstracts (2022) 84 PS3-13-115 | DOI: 10.1530/endoabs.84.PS3-13-115

1Ku Leuven, Clinical & Experimental Endocrinology, Leuven, Belgium; 2Az St Jan Brugge, Department of Endocrinology, Brugge, Belgium; 3Ku Leuven, Medicine, Leuven, Belgium; 4Olvz Aalst-Asse-Ninove, Endocrinology, Belgium; 5Uz Leuven; 6Uz Leuven, Obstetrics & Gynecology; 7Olvz Aalst-Asse-Ninove, Obstetrics & Gynecology, Belgium; 8Imelda Bonheiden, Endocrinology, Belgium; 9Imelda Bonheiden, Obstetrics & Gynecology, Belgium; 10Uz Antwerpen, Endocrinology, Belgium; 11Uz Antwerpen, Obstetrics & Gynecology, Belgium; 12Kliniek St-Jan Brussel, Endocrinology, Belgium; 13Kliniek St-Jan Brussel, Obstetrics & Gynecology, Belgium; 14Ku Leuven, Center of Biostatics and Statistical Bioinformatics, Belgium; 15Uz Leuven, Obstetrics & Gynecology, Belgium; 16Uz Leuven, Leuven, Belgium; 17Ku Leuven, University Hospitals Leuven, Endocrinology, Leuven, Belgium; 18Uz Leuven, Endocrinology, Belgium

Aim: To determine the association between thyroid function and the risk for gestational diabetes mellitus (GDM) and adverse pregnancy outcomes.

Methods: This case-control study was a sub-analysis of the BEDIP-N study, in which 199 GDM women were matched for age and body mass index with 398 controls. Thyroid stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3), and thyroid peroxidase (TPO) antibodies were measured at 6-14 weeks and 26-28 weeks pregnancy. TSH and fT4 were also measured in early postpartum in GDM women.

Results: TSH and TPO were not associated with the risk to develop GDM. The fT3-to-fT4 ratio at 26-28 weeks was positively associated with GDM risk with an adjusted odds ratio (aOR for smoking, education, parity, ethnicity, gestational weight gain and (family) history of diabetes or GDM) of 2.12 (95% CI 1.07; 4.23) comparing the highest with the lowest tertile. Higher fT3 levels and fT3-to-fT4 ratio were associated with a less favorable metabolic profile with higher BMI and more insulin resistance in pregnancy and postpartum. Women in the upper fT3 tertile and upper fT3-to-fT4 ratio had a higher rate of preeclampsia [respectively 4.6% (10) vs. 1.0% (2), P = 0.040, and 4.4% (9) vs. 0.5% (1), P = 0.020], gestational hypertension [8.3% (18) vs. 3.1% (6), P = 0.034 and 8.9% (18) vs. 2.0% (4), P = 0.003], and caesarean sections [29.4% (63) vs. 16.1% (31), P = 0.002 and 32.2% (65) vs. 12.7% (25), P < 0.001].

Conclusion: Higher fT3-to-fT4 ratio late in pregnancy was associated with GDM, adverse pregnancy outcomes, and an adverse metabolic profile in early postpartum.

Volume 84

44th Annual Meeting of the European Thyroid Association (ETA) 2022

Brussels, Belgium
10 Sep 2022 - 13 Sep 2022

European Thyroid Association 

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