Endocrine Abstracts

Introduction: Hyponatremia is the most common electrolyte disorder in hospitalized patients. SIADH is characterized by euvolemic hyponatremia with sodium and urine osmolality inappropriately high. The selective antagonist of the vasopressin V2 receptor (tolvaptan) helps to eliminate water free of solute (aquaresis), being effective in treating this condition.Objetive: Evaluate the efficacy and safety of tolvaptan in the treatment of SIADH.<p class="a...

Introduction: Thyroid dysfunction has been described as a common clinical entity in HIV infected patients, commonly with negative autoimmune tests. The aim of this work was to determine the prevalence of thyroid abnormalities in a cohort of HIV-infected males in a stable clinical state, the effect of exposure to ART on thyroid function and to identify the risk factors.Materials and methods: This is a cross-sectional, observational study of 90 HIV infecte...

The mTOR and IGF pathways have been suggested to play a role in the pathogenesis of pheochromocytomas (PCC). mTOR inhibitors, as sirolimus (S) and everolimus (E), as well as IGF1R antagonists could be a potential novel treatment for malignant PPC.The aim of this study was to evaluate the expression of the main components of the IGF/mTOR pathway in human PCC and to investigate the effects of the mTOR inhibitors S and E and of the IGF1R/insulin receptor (I...

Objective: The soluble leptin receptor (sOb-R) is generated by ectodomain shedding of the membrane-associated Ob-R and may modulate leptin action in metabolic dysregulations. The objective of our study was to investigate whether or not sOb-R generation may be induced by indicators of energy availability or metabolic regulators in a cell model.Material and methods: The four human Ob-R isoforms were cloned, characterized by binding experiments with 125-iod...

Ghrelin, the natural ligand for the GHS-R, modulates proliferation in cell lines derived from malignant breast tissue. It has been suggested that this action is independent of the GHS-R. We have previously demonstrated that MCF7 cells expressed ghrelin but not GHS-R mRNA and MDA-MB231 cells expressed GHS-R but not ghrelin mRNA. To determine whether ghrelin modulates proliferation in MCF7 and MDA-MB231 cells we performed proliferation assays treating with saline, 1 and 10nM ghr...

Introduction: Obesity and its associated chronic comorbidities represent a worldwide health problem in epidemic increase. Recent researches have reported notable differences in the amino acids metabolism signatures between obese, mild insulin resistant but non-diabetic, and lean individuals. Moreover, amino acids metabolites are emerging as strong predictors in the development of diabetes in obesity. The contribution of the obese adipose tissue from various depots to the syste...

Introduction: HIV-infected patients often display a moderate to severe GH deficiency (GHD). To investigate the effects of r-hGH on hormonal parameters and body composition in patients with HIV-related lipodystrophy (HIV-r-L) and concomitant GHD, we studied 60 patients with HIV-r-L, 28 male and 32 females aged 18–65 years. According to their response to GHRH+Arginine (GH peak assumed to be normal when >7.5 ng/ml) patients were assigned to the following 3 groups: Group ...

Background: Adult growth hormone (GH) deficiency (AGHD) is related with alterations in body composition, increased abdominal and visceral adiposity, adverse change in lipid and carbohydrate metabolism, and reduction of bone mineral density (BMD).Aim: To compare baseline outcomes concerning body composition and biochemical/hormonal data among adult patients with AGHD referring to a single endocrinological center and grouped according to their history of r...

Objectives: Eating disorders often co-occur with diabetes, and this comorbidity is associated with severe medical complications. The DEPS-R is a 16-item diabetes-specific self-report measure of disordered eating that can be completed in <10 min. The purpose of the study was to translate and validate the Russian version of the Diabetes Eating Problem Survey–Revised (DEPS-R).Methods: 372 patients with diabetes mellitus using insulin injections par...

The gut microbiota is now the subject of considerable investigation and our knowledge of its composition and understanding of functions are rapidly growing.Gut microbiota has profound impact on host physiology and it is now well-established that dysbiosis is associated with altered glycemic control and type 2 diabetes development. Targeting microbiota appears therefore as a promising strategy for the treatment of diabetic patients. Using probiotics in order to modulate blood g...