Endocrine Abstracts

Background: The prevalence of hypothyroidism is around 1–2% in the UK. Hashimoto’s thyroiditis is thought to cause 0.1–2% of overt disease and 10–15% of subclinical hypothyroidism. This case presents a patient with severe hypothyroidism, secondary to Hashimoto’s thyroiditis, found incidentally on a surgical admission. The case study discusses the challenges and management of severe hypothyroidism in the need for an acute surgical intervention....

Yu Pei and Sanjiv Risal are joint first authors. Elisabet Stener-Victorin and Qiaolin Deng are joint corresponding authors. Polycystic ovary syndrome (PCOS) affects around 15% of women of reproductive age and the key feature of the syndrome is hyperandrogenism. To understand the complex pathophysiology of PCOS, more than 30 PCOS-like animal models have been developed to mimic certain pathophysiological features. So far, not much is known about the common and unique molecular a...

Objective: To investigate frequency of secondary GH deficit (SGHD) in patients with acromegaly in the Republic of Uzbekistan (RUz).Material and methods: There are 366 patients with acromegaly registered in RUz. We observed 15 patients with acromegaly with SGHD, among them 3 male and 12 female with middle age 51.6 years. All patients undergone following tests: pituitary hormones levels (GH, IGF1, ACTH, prolactin, TSH, FSH, LH, etc.), blood glucose, bioche...

Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED), is a rare autosomal recessive cause of polyendocrinopathy. Mutations in the AIRE (Autoimmune regulator) gene results in failure of T cell tolerance. APECED occurs in about 1 in 90,000 to 1 in 200,000 people but is more prevalent in certain groups (Iranian Jews, Sardinians, and Finns). Its presentation depends on the gene mutation. The classic triad of symptoms are chronic mucocutaneous candidiasis, hypopa...

Background: Patients with acromegaly usually presented symptoms of the hypersecretion of growth hormone (GH). GH may increase insulin-like growth factor 1 (IGF-1), affect energy homeostasis, and cause complications in cardiovascular, skeletal, or metabolic systems. Follistatin is a glycoprotein with various biologic functions that plays a role in adipocyte differentiation, muscle stimulation, anti-inflammation and energy homeostasis. We evaluated the serum levels of follistati...

Introduction: Subjects with papillary thyroid cancer (PTC) usually have a long survival time after diagnosis. However, the prognosis of PTC subjects with lung metastasis noted at the time of initial diagnosis is unknown.Material and methods: From 1998 to 2009, patients with PTC were recruited by medical chart review. Patients with lung metastasis at initial diagnosis (PTC-L) were identified. Their follow-up courses were evaluated and compared to patients...

Objective: Myostatin may negatively regulate skeletal muscle mass. Serum myostatin levels have positive associations with obesity and insulin resistance. Thyroid dysfunction may affect body weight, energy expenditure, and glucose metabolism. We evaluated the serum myostatin levels in different thyroid function statuses.Subjects and methods: We recruited 30 newly-diagnosed hyperthyroid (HY) patients and treated them with anti-thyroid regimens as clinicall...

Objective: Craving of sweet foods and sucrose may be a big obstacle for glycemic control of diabetic patients. It is generally believed that diabetic patients may prefer sweet taste. However, few studies have examined sucrose preference in diabetic patients. Therefore, we investigated changes in sucrose preference in diabetic condition.Research design and methods: We performed two-alternative staircase methods and forced-choice tracking procedures to ass...

Objective: To estimate the value of the questionnaire QoL – AGHDA, KIMS for revealing of GH deficiency (GHD) in adults for estimation of the condition of patients with various pituitary adenomas.Material and research methods: We examined 72 adult patients with pituitary adenomas and GHD from 2008 till 2009. From them there were 30 men (41.6%), and 42 women (58.3%). Middle age was 38.0 years.Research methods included: i) Clinic...

Aim of the research: To reveal neuroendocrine disorders rate in patients with different pituitary adenomas retrospectively.Patients and methods: We analyzed 81 patients records with different pituitary adenomas from 2000 to 2009. Of 81 patients 23 were men (28.4%) and 58 women (71.6%). Mean age of male patients was 37.2 years-old whereas in women this was 34.5 years-old.1st group of patients was with Cushing’s disease (CD) &#1...