Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2011) 26 P159

ECE2011 Poster Presentations Neuroendocrinology (36 abstracts)

Frequency of secondary GH deficit in patients with acromegaly undergone radiation or surgical treatment

Yu M Urmanova 1, & M Yu Shakirova 1,


1Republican Specialized Scientific-Practical Medical Center of Endocrinology under the Ministry of Health of the Republic of Uzbekistan, Tashkent, Uzbekistan; 2Tashkent Medical Pediatric Institute, Tashkent, Uzbekistan.


Objective: To investigate frequency of secondary GH deficit (SGHD) in patients with acromegaly in the Republic of Uzbekistan (RUz).

Material and methods: There are 366 patients with acromegaly registered in RUz. We observed 15 patients with acromegaly with SGHD, among them 3 male and 12 female with middle age 51.6 years. All patients undergone following tests: pituitary hormones levels (GH, IGF1, ACTH, prolactin, TSH, FSH, LH, etc.), blood glucose, biochemical blood indicies, ECG, pituitary MRI/CT, densitomertry, visual fields, and others. Total hypophisectomy (THE) was performed to 4 patients, pituitary radiation therapy (PRT) – to 8 patients, THE+PRT – to 1 patient. Two patients undergone medical treatment.

Study results: We established that mean level of GH was significantly decreased (by 0.4±0.01 ng/ml). IGF1 level were also significantly decreased (97.5±7.3 ng/ml). All patients had deficit of 2 or 3 stimulating hormones, including SGHD.

We revealed post radiation hypopituitarism in 8 patients (53.3%), post operative hypopituitarism in 4 (26.6%), and combined hipopituitarism – in 1 (6.6%) patient. In 2 patients (13.3%) hipopituitarism has developed after medical treatment.

Conclusion: According to preliminary data, SGHD in patients with acromegaly may be the criterion of the process remission.

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