Searchable abstracts of presentations at key conferences in endocrinology
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13th European Congress of Endocrinology

Poster Presentations


ea0026p155 | Neuroendocrinology | ECE2011

Short-term balneotherapy is associated with changes in salivary cortisol levels

Matzer F , Bahadori B , Fazekas C

Since ancient times, physicians have speculated that balneotherapy (therapeutic bathing in medicinal and thermal springs) has a stress-relieving effect, but this has not yet been scientifically established. The aim of this study was to evaluate the stress-relieving effects of short-term balneotherapy in a controlled trial by measuring salivary cortisol as a sensitive stress marker. Forty-nine healthy probands were randomised into three intervention groups. Group one performed ...

ea0026p156 | Neuroendocrinology | ECE2011

Character of macrovascular complications as per the Uzbekistan National Register of patients with the combined diabetes mellitus and diabetes insipidus

Ismailov S I , Khalimova Z Yu , Urmanova Yu M , Alieva D A , Aripova V

Aim: To study character of macrovascular complications in combination of diabetes mellitus (DM) and diabetes insipidus (DI).Materials and methods: Within the period from 2006 to 2010, we examined 2208 cases of DI among them 106 DM–DI combinations. The patients had their endocrine and neurologic statuses assessed with blood and urine density investigation, including complete urinalysis and Zimnitskyi urine count, RIA and measurement of pituitary horm...

ea0026p157 | Neuroendocrinology | ECE2011

Clinical presentation peculiarities of constitutional puberty delay in boys

Urmanova Yu M , Mavlonov U Kh

Aim: To study clinical presentation peculiarities of constitutional puberty delay in boys.Materials and methods: We examined 54 boys (mean age 13.8 years) with constitutional puberty delay (CPD). All examinees underwent general clinical examination as well as biochemical and hormonal investigations (levels of GH, LH, FSH, free testosterone, prolactin, cortisol, TSH, etc.), having their bone age and anthropometric parameters by Tanner-Whitehouse measured ...

ea0026p158 | Neuroendocrinology | ECE2011

Evaluation of the questionnaire for revealing of GH deficiency in adults with various pituitary adenomas

Shakirova M Yu

Objective: To estimate the value of the questionnaire QoL – AGHDA, KIMS for revealing of GH deficiency (GHD) in adults for estimation of the condition of patients with various pituitary adenomas.Material and research methods: We examined 72 adult patients with pituitary adenomas and GHD from 2008 till 2009. From them there were 30 men (41.6%), and 42 women (58.3%). Middle age was 38.0 years.Research methods included: i) Clinic...

ea0026p159 | Neuroendocrinology | ECE2011

Frequency of secondary GH deficit in patients with acromegaly undergone radiation or surgical treatment

Urmanova Yu M , Shakirova M Yu

Objective: To investigate frequency of secondary GH deficit (SGHD) in patients with acromegaly in the Republic of Uzbekistan (RUz).Material and methods: There are 366 patients with acromegaly registered in RUz. We observed 15 patients with acromegaly with SGHD, among them 3 male and 12 female with middle age 51.6 years. All patients undergone following tests: pituitary hormones levels (GH, IGF1, ACTH, prolactin, TSH, FSH, LH, etc.), blood glucose, bioche...

ea0026p160 | Neuroendocrinology | ECE2011

Hormonal disorders in patients with acromegaly in Khorezm region, Republic of Uzbekistan

Urmanova Rikhsieva , Khodjaev Sh O , Eshmetov Sh A , Rakhmetova M A , Khodjaeva F S , Azizov B A

Aim: To study spectrum of hormonal disorders in patients with acromegaly, residents of Khorezm region, Republic of Uzbekistan.Materials and methods: We examined 22 acromegalics (9 men and 13 women, mean age 39.8 years), residents of Khorezm region, Republic of Uzbekistan. All patients were clinically and biochemically examined with their hormonal parameters, such as levels of GH, LH, FSH, IGF1, prolactin, cortisol and TSH measured, ECG, perimetry and pit...

ea0026p161 | Neuroendocrinology | ECE2011

Incidence of diabetes mellitus and diabetes insipidus combination in the Republic of Uzbekistan

Khalimova Z Yu , Urmanova Yu M , Alieva D A , Aripova V

Aim: To study clinical–epidemiological peculiarities of diabetic macroangiopathies in diabetes mellitus (DM) and diabetes insipidus (DI) combination.Materials and methods: We examined 2208 cases of DI registered in the RUz in 2006–2010, 106 DM–DI combinations among them. DM–DI combination prevalence, calculated for 100 000 of adult and infant population, was assessed analysis of data on patients registered at the endocrine ambulances....

ea0026p162 | Neuroendocrinology | ECE2011

Incidence of puberty delay risk factors in boys

Urmanova Yu M , Mavlonov U Kh

Aim: To study significance of risk factors in puberty delay in boys.Materials and methods: We examined 54 boys (mean age 13.8 years) with constitutional puberty delay (CPD). All examinees underwent general clinical examination as well as biochemical and hormonal investigations (levels of GH, LH, FSH, free testosterone, prolactin, cortisol, TSH, etc.), having their bone age and anthropometric parameters by Tanner-Whitehouse measured and their sexual devel...

ea0026p163 | Neuroendocrinology | ECE2011

Structure of neuroendocrine disorders rate in patients with different pituitary adenomas (retrospective analysis)

Shakirova M Yu

Aim of the research: To reveal neuroendocrine disorders rate in patients with different pituitary adenomas retrospectively.Patients and methods: We analyzed 81 patients records with different pituitary adenomas from 2000 to 2009. Of 81 patients 23 were men (28.4%) and 58 women (71.6%). Mean age of male patients was 37.2 years-old whereas in women this was 34.5 years-old.1st group of patients was with Cushing’s disease (CD) &#1...

ea0026p164 | Neuroendocrinology | ECE2011

Sexual desire in female-to-male transsexual persons

Wierckx K , Van De Peer F , Dedecker D , Van Caenegem E , Elaut E , T'Sjoen G

Objective: The current study aims to describe sexual desire in female-to-male transsexuals post SRS (sex reassignment surgery) using a validated questionnaire. The association between serum androgen levels and the intensity and frequency of sexual desire are examined. The data are compared to those of male-to-female transsexual persons.Design: Cross sectional study.Methods: Female-to-male transsexual persons, post SRS, (n=48...

ea0026p165 | Neuroendocrinology | ECE2011

Role of IGF1 system in human longevity. A study in a wide population of centenarians and centenarians’ offspring

Vitale G , Brugts M P , Ogliari G , Castaldi D , Fatti L M , Hofland L J , Monti D , Cavagnini F , Franceschi C , Mari D , Janssen J A M J L

Increasing evidence has recently accumulated suggesting that IGF1 system is involved in the regulation of longevity. While in animal models alterations of IGF1 signalling increase life expectancy, in humans there are contradictory data. Centenarians are an extraordinary model to study human longevity, however, they present a number of drawbacks: rarity, frailty due to extreme age and lack of a control group of the same age. The availability of an age-matched control group is c...

ea0026p166 | Neuroendocrinology | ECE2011

Evaluation of insulin secretion and sensitivity and lipid profile in GH deficient children before and at the end of rhGH therapy

Prodam F , Savastio S , Bellone S , Balossini C , Ricotti R , Genoni G , Aimaretti G , Bona G

Introduction: A rise in serum insulin levels during GH therapy is reported. Insulin resistance is a risk factor for type 2 diabetes, atherosclerosis, dyslipidemia, and hypertension. Few data describe insulin secretion and lipids after the end of GH therapy.Subjects and methods: Aim of our study was to evaluate changes in insulin secretion, sensitivity and lipid profile in children with isolated GHD longitudinally followed during rhGH treatment. We measur...

ea0026p167 | Neuroendocrinology | ECE2011

Immune status and functional activity of blood neutrophils in patients with active acromegaly

Dudina M A , Dogadin S A , Savchenko A A

The chronic GH and IGF1 excess causes a specific changes in immune system due to presence of its receptors on T-, B-lymphocytes, granulocytes. The aim of this study was to evaluate the subpopulation composition and chemiluminescence’s indices of neutrophils in patients with active acromegaly.Thirty-three patients with active acromegaly (11 men and 22 women, mean age 51.7±11.7 years) and 53 healthy subjects sex- and age-matched with the patients...

ea0026p168 | Neuroendocrinology | ECE2011

Dexamethasone supression test (BDST) and bilateral inferior petrosal sinus sampling (BIPSS) in diagnosis of ACTH: dependent hypercortisolism

Dreval A , Komerdus I , Britvin T , Demidov I , Nechaeva O , Murzina A , Denisova L

Background: BIPSS is the most reliable procedure for differentiation Cushing’s disease (CD) from ectopic ACTH secretion (EAS).Aim: To determine the comparability of 8-mg dexamethasone supression test (BDST) and BIPSS for differential diagnosis ACTH-dependent hypercortisolism.Materials and methods: We present 6 patients with confirmed ACTH-dependent hypercortisolism. All of them BDST (8 mg dexamethasone at 2300 h) and BIPSS (wi...

ea0026p169 | Neuroendocrinology | ECE2011

The NAD- and NADP-dependent blood lymphocytes dehydrogenases activity in acromegaly

Dudina M A , Dogadin S A , Savchenko A A

GH and IGF1 regulate plastic and synthetic intracellular lymphocytes process. We aimed to investigate the NAD- and NADP-dependent dehydrogenases activity in blood lymphocytes in patients with active acromegaly.Thirty-three patients (11 men and 22 women, mean age 51.7±11.7 years), with the 6–10 years active phase duration of acromegaly, and 53 age- and gender matched healthy controls were determined the activity of NAD(P)-dependent dehydrogenase...

ea0026p170 | Neuroendocrinology | ECE2011

Metabolic encephalopathy and quadriparesis induced by severe hyponatremia in the patient with Sy Seehan

Bogdanovic Jelena , Perusko Radmila Stojanovic , Popovic Dragana , Dzomlija Radojka , popovic Vera , Ercegovac Marko , Bogdanovic Ljiljana , Micic Dusan

Sy Sheehan or postpartal pituitary necrosis presents with symptoms and signs of hypopituitarisms. It is usually a consequence of complicate delivery followed by intensive uterine bleeding. Diagnosis can be delayed years after delivery, up to 20 years.We present a case of 51-year-old female patient. She was admitted in the department of neurology in the Emergency center, Belgrade, with disturbance of consciousness. Few days before she felt leg weakness an...

ea0026p171 | Neuroendocrinology | ECE2011

Effects of orexin–monoaminergic interactions on vasopressin secretion in rat neurohypophyseal cell cultures

Kis G K , Galfi M , Radacs M , Kadar K , Molnar Z , Molnar A H , Laszlo F , Varga C , Laszlo F A

Introduction: The effects of dopamine (DA), serotonin (5-HT), histamine (HA) adrenaline (ADR), noradrenaline (NADR) and K+ administration on vasopressin (VP) secretion were studied in 13–14 days cultures of rat neurohypophyseal (NH) cells, and it was examined whether orexin (ORX) can modify the VP release enhancement induced by these monoaminergic compounds.Methods: An enzymatic dissociation technique was used to prepare the rat NH cell c...

ea0026p172 | Neuroendocrinology | ECE2011

Age related distribution of the endothelial nitric oxide synthase gene G894T polymorphism: relationship with metabolic-endocrine and cognitive features

Ianas O , Manda D , Heltianu C , Vladoiu S , Popa O , Rosca R , Oros S , Covic M , Joja O

Background: Genetic variants of the endothelial nitric oxide synthase (eNOS) gene have been reported to be associated with vascular disease. We hypothesized that G894T polymorphism might trigger many of the endocrine-metabolic cognitive changes related to aging.Study design: One hundred and eighty subjects aged 55–80+ years with moderately cognitive impairment (MCI) (MMSE<28) (lot 1), 140 age-matched subjects without cognitive impairment (MMSE&#...

ea0026p173 | Neuroendocrinology | ECE2011

Glucose homeostasis in GH deficient adults not treated with GH: more than 10 year follow-up

Djurdjevic S Pekic , Doknic M , Stojanovic M , Miljic D , Djurovic M , Stojanoska M Medic , Popovic V

Study objective: We investigated prevalence of impaired glucose homeostasis in a large cohort of adult patients with GH deficiency (GHD), not treated with GH after more than 10 years of follow-up.Design: Seventy-one adult GHD patients (30 males, 41 females; mean age 48.3±2.0 years, mean BMI 28.8±0.7 kg/m2, GH deficient for 10.2±1.2 years) were evaluated. Ninety percent of patients had multiple pituitary hormone deficiencies whic...

ea0026p174 | Neuroendocrinology | ECE2011

A raised GRα/β expression ratio in monocytes of schizophrenic and bipolar patients

Weigelt K , Spijker A , Drexhage R C , Wijkhuijs A M , Drexhage H A

Purpose: Individuals with mood disorders and schizophrenia (SCZ) exhibit altered function of the HPA axis in response to stress. The glucocorticoid receptor (GR) plays an important role in negative feedback regulation of the HPA-axis. There are two protein isoforms, GRα and GRβ, which have activating and blocking activity respectively. In line with aberrant expression of GR mRNA in the brains of depressed, SCZ and bipolar (BD) patients (1), lymphocytes of depressed, ...

ea0026p175 | Neuroendocrinology | ECE2011

The role of food choice in the effects of a high-fat high-sugar diet on leptin sensitivity

van den Heuvel J K , Eggels L , Luijendijk M C M , Kalsbeek A , Fliers E , Adan R A H , la Fleur S E

Background: Rats on a free-choice (fc) diet of saturated fat and liquid sugar in addition to chow (fcHFHS) overeat persistently, and show increased hypothalamic neuropeptide Y and decreased melanocortin signaling, which reflects a hunger state despite hyperphagia. This response is specific for a fcHFHS diet, because when given the choice between fat and chow (fcHF) or between liquid sugar and chow (fcHS) hyperphagia is not observed. Because leptin signaling is important for th...

ea0026p176 | Neuroendocrinology | ECE2011

Hypothalamic neuropeptide Y controls the hepatic secretion of VLDL triglycerides in rats via the sympathetic nervous system

Bruinstroop E , Pei L , Ackermans M , Fliers E , Kalsbeek A

During fasting neuropeptide Y (NPY) neurons in the mediobasal hypothalamus are activated to increase food intake and to conserve energy. Under conditions of food deprivation, lipid metabolism plays an important role in providing fuel for muscle. We investigated if central NPY affects VLDL-TAG secretion directly via the autonomic nervous system. We measured VLDL-TAG secretion in Wistar rats by an intravenous bolus of tyloxapol to inhibit uptake of triglycerides by peripheral ti...

ea0026p177 | Neuroendocrinology | ECE2011

Inverse association of dehydroepiandrosterone sulfate with stroke severity and poor functional outcome in a female stroke population

Pappa T , Vemmos K , Saltiki K , Mantzou E , Stamatelopoulos K , Alevizaki M

Introduction: DHEAS is among the most abundant sex steroid products of the adrenal gland. DHEAS levels have been repeatedly associated with cardiovascular disease, but data concerning cerebrovascular disease, especially in women, is lacking. In this study, we aimed to investigate the role of DHEAS in a female population suffering an acute stroke.Patients and methods: We studied 302 consecutive female patients presenting with an acute stroke hospitalized ...

ea0026p178 | Neuroendocrinology | ECE2011

Normosmic congenital hypogonadotropic hypogonadism due to TAC3/TACR3 mutations: characterization of neuroendocrine phenotypes and novel mutations

Francou B , Bouligand J , Voican A , Amazit L , Brailly-Tabard S , Lecomte P , Young J , Guiochon-Mantel A

Introduction: TAC3/TACR3 mutations have been reported in normosmic congenital hypogonadotropic hypogonadism (nCHH). In the absence of animal models, studies of human neuroendocrine phenotypes associated with neurokinin B and NK3R receptor dysfunction can help to decipher the pathophysiology of this signaling pathway. Our objective was to characterize novel TACR3 mutations and to analyze neuroendocrine profiles in nCHH patients with TAC3/TACR3 biallelic mut...

ea0026p179 | Neuroendocrinology | ECE2011

X-linked adrenoleukodystrophy: an intersection between Endocrinology and Neurology

Gouveia S , Gomes L , Ribeiro C , Vieira A , Alves M , Saraiva J , Carvalheiro M

Introduction: X-linked adrenoleukodystrophy (X-ALD) is an important cause of primary adrenocortical insufficiency (PAI) in men. It’s characterized by impairment in peroxisomal degradation of very-long-chain-fatty-acids (VLCFA), leading to its accumulation on central nervous system, adrenal cortex and testes.Adrenomyeloneuropathy, the most common phenotype of X-ALD, coexists with PAI in up to 70% cases.Case report: A 28-year-ol...

ea0026p180 | Neuroendocrinology | ECE2011

Targeting PKC in human pancreatic neuroendocrine tumor cells

Mole D , Gagliano T , Gentilin E , Bondanelli M , Tagliati F , degli Uberti E , Zatelli M C

The currently curative therapy for pancreatic endocrine tumours (PET), accounting for <3% of pancreatic tumors, is complete surgical resection, which is achieved in the minority of cases. Most tumors are diagnosed in a late stage, especially in endocrine-inactive forms, indicating the need for further medical therapy. The serine–threonine protein kinase C (PKC) family plays central regulatory roles in several cellular processes, including cell proliferation. PKC signa...

ea0026p181 | Neuroendocrinology | ECE2011

GH enhances breast cancer chemoresistance by inhibiting JNK-mediated apoptosis

Minoia M , Gentilin E , Tagliati F , Mole D , Ambrosio M R , Baroni A , degli Uberti E , Zatelli M C

GH and insulin-like growth factor 1 (IGF1) are known to promote breast carcinogenesis. Breast cancer (BC) incidence in not increased in female acromegalic patients, but mortality is greater as compared to general population. We previously demonstrated that GH/IGF1 excess influences BC response to therapy, possibly accounting for the increased mortality. We indeed showed that GH and IGF1 induce cell proliferation of a BC cell line, the MCF7 cells, providing protection towards t...

ea0026p182 | Neuroendocrinology | ECE2011

Glycoproteic pituitary hormones in the cerebrospinal fluid of patients with pituitary adenomas

Coculescu M , Capatina C , Caragheorgheopol A , Dumitrascu A , Hortopan D , Raica M , Cimpean A M , Constantinoiu S , Gandea C

Introduction: The concentrations of pituitary hormones in the cerebrospinal fluid (CSF) are much lower that their serum counterpart.Aim: To study the CSF access for pituitary glycoprotein hormones (GPH) in patients with pituitary adenomas (PA).Patients and methods: In 221 cases submitted to transsphenoidal surgery for PA (85 acromegaly – ACM, 92 nonfunctioning pituitary adenomas – NFA, 44 prolactinomas – PRM) the sur...

ea0026p183 | Neuroendocrinology | ECE2011

Hipothalamo–pituitary–adrenal axis function in posttraumatic stress disorder

Bozic I , Macut D , Popovic B , Isailovic T , Petakov M , Ognjanovic S , Bogavac T , Damjanovic S

Introduction: Posttraumatic stress disorder (PTSD) is anxious disorder that occurs following exposure to trauma. In the last two decades, numerous studies showed that dysregulation of hipothalamo–pituitary–adrenal axis (HPAA) is a core feature of the PTSD. Still, results are heterogeneous and often conflicted with one another. Therefore, we conducted strictly controlled study in order to characterize relationship between ACTH and cortisol secretion in patients with c...

ea0026p184 | Neuroendocrinology | ECE2011

Vasopressin and vasopressin receptor expression in the rodent retina

Saunders C , Rowe I , Widmer H , Ludwig M

Vasopressin acts through G protein-coupled receptors on the cardiovascular and renal system to induce vasoconstriction and antidiuresis. Vasopressin also has important functions within the CNS influencing cognition, olfaction and a range of complex social interactions and behaviours. In addition, vasopressin has been reported in the mammalian retina and here we investigated the location and expression of vasopressin and vasopressin receptors (V1a, V1b, and V2) in the rat retin...

ea0026p185 | Neuroendocrinology | ECE2011

Serum leptin levels in patients with Alzheimer’s disease

Rizoulis A A , Karaoulanis S E , Dardiotis E , Rizouli K A , Bargiota A , Hadjigeorgiou G M , Papadimitriou A

Introduction: Leptin receptors have been identified in many peripheral tissues as well as the CNS including the hippocampus, which is particularly vulnerable in Alzheimer’s disease (AD). Animal data shows that leptin may be implicated in the pathophysiology of AD. The aim of this study was to examine if there is any differences in serum leptin levels between patients with AD and normal controls.Material and methods: Ninety patients with AD and 95 no...

ea0026p186 | Neuroendocrinology | ECE2011

Estrogen signaling in the hypothalamus regulates glucose metabolism in female rats

Liu J , Bisschop P , Eggels L , Foppen E , Zhou J N , Fliers E , Kalsbeek A

Background: Previous studies reported that direct injection of estrogen (E2) into different hypothalamic nuclei affects food intake, body weight and locomotor activity. We hypothesized that E2 signaling in the hypothalamus regulates glucose metabolism independently of circulating estrogen levels.Methods: We investigated the effects of hypothalamic estrogen administration on basal glucose production as well as on hepatic and peripher...

ea0026p187 | Neuroendocrinology | ECE2011

The role of the Diphereline (Triptoreline) test in the etiological diagnosis of gonadal dysfunction

Dobrescu Ruxandra , Militaru Roxana , Jercalau Simona , Gavan Vadim , Caragheorgheopol Andra , Badiu Corin

Objective: To assess the usefulness of the GnRH analogue Diphereline (Triptoreline) in the evaluation of central gonadal dysfunction in children and adults.Methods: A 18-month retrospective study of dynamic testing of the hypothalamic pituitary gonadal axis in 36 patients, 10 prepubescent children (<13 years for girls and 14 years for boys) and 26 postpubescent subjects. The children were investigated for disorders of sexual development while the adu...

ea0026p188 | Neuroendocrinology | ECE2011

Glucocorticoid receptor gene polymorphisms are associated with disease course during pregnancy and the post-partum period in rheumatoid arthritis

Quax R A M , de Man Y A , Koper J W , Willemsen S P , Lamberts S W J , Hazes J M W , Dolhain R J E M , Feelders R A

Background: The mechanism underlying the spontaneous improvement of rheumatoid arthritis (RA) during pregnancy and the subsequent post-partum flare is incompletely understood. The glucocorticoid receptor (GR) polymorphisms Bcl1 and 9β are associated with an increased and decreased glucocorticoid sensitivity respectively. We examined the relation between carriership of these functional GR polymorphisms and disease course during pregnancy and post-partum in RA...

ea0026p189 | Neuroendocrinology | ECE2011

Cabergoline influence on antioxidative protection enzymes activity in complex therapy in patients with non-functioning pituitary adenoma (NFPA)

Ismailov S I , Khalimova Z Yu , Kholova D Sh

Aim: To evaluate influence of cabergoline on LAO and BAS processes in treatment of patients with NFPA.Materials and methods: We included 64 patients with NFPA in the study. Mean age was 43.6±3.84 years (range 30–55 years). Of 64 patients 26 (40.6%) were men and 38 (59.4%) were women. Duration of the disease from diagnosis based on MRI constituted 1–15 years. Severity criteria used in the evaluation were LH, FSH and prolactin (PRL) growth a...

ea0026p190 | Neuroendocrinology | ECE2011

The role of centrally applied ghrelin on hypothalamic AMPK activity and pituitary–adrenal responses in differently fed rats

Stevanovic Darko , Milosevic Verica , Nesic Dejan , Micic Dragan , Sumarac-Dumanovic Mirjana , Popovic Vera , Starcevic Vesna

The pandemic increase of obesity, malnutrition and associated comorbidities encouraged intensive studies on energy balance control. Ghrelin is a brain-gut orexigenic hormone that is involved in both the short-term and long-term regulation of energy homeostasis. The aim of this research was to investigate the role of centrally applied ghrelin on the pituitary morphofunctional features and corticosterone secretion in normal-fed, food-restricted and obese 8 weeks old Wistar male ...