Endocrine Abstracts

Aim: To study the effect of testosterone replacement treatment in the aging male with T2DM.Material and methods: Twenty-six hypogonadal men with T2DM and late-onset hypogonadism (Total testosterone at diagnosis <12 nmol/l) between the age 50–65 years (55.00 (50.00;58.00)) were treated with a 1% testosterone gel (AndroGel) (5 g/day) within 6 months. Patients were assessed before the first using of AndroGel, in one week interval and in 6 months. A...

Hypogonadism occurs in myotonic dystrophy (DM) type 1 and 2, a multisystemic autosomal dominant disorder. DM patients have genetically induced insulin-resistance (IR) and visceral obesity, providing a model to study the impact of metabolic disruptions on hypogonadism. We assessed hypothalamic-pituitary-gonadal function and metabolic features in 22 DM1 and 8 DM2 males (mean±S.D., 46±11years). Hypogonadism, defined as total testosterone (T)<320 ng/dl...

Introduction: The disorders of orgasm/ejaculation include premature ejaculation, delayed ejaculation and perceived ejaculate volume reduction (PEVR). To explore the specific associations of PEVR in subjects with erectile dysfunction (ED).Methods: A consecutive series of 3141 subjects (mean age 51.6±13.1 years old) was studied. Among these, 71 have been excluded because they underwent prostate surgery. Different clinical and biochemical factors were ...

Introduction: Perceived reduced sleep-related erections (PR-SREs), along with erectile dysfunction (ED) and hypoactive sexual desire, have been recently recognized as the most important symptoms characterizing late onset hypogonadism in community-dwelling European men. However, the clinical correlates of PR-SREs have not been thoroughly investigated. The aim of this study is to evaluate the psychobiological correlates of PR-SREs in a large series of subjects consulting for ED....

Background: Hypogonadism is a major feature of Prader–Willi syndrome, but clinical manifestations are variable. Sexual interests and behavior in this population have not been previously described.Objectives: We studied PWS adolescents and young adults to assess: i) satisfaction with physical and sexual development ii) frequency of romantic and sexual experiences, iii) aspirations and expectations regarding marriage, iv) investigate the relation betw...

Background: The penis has been compared to a barometer of endothelial health, being erectile dysfunction (ED) an early sign of endothelial dysfunction. The aim of the study was to investigate the association between ED and endothelial dysfunction in patients with HIV infection on ART.Methods: In this observational cross-sectional study we evaluated the prevalence and factors associated with ED in a cohort of 133 HIV-infected men. Evaluation tools include...

AROM+ mice express universally the human P450 aromatase enzyme, leading to increased serum and intratesticular E2/T ratio. AROM+ mice are infertile and present with testicular inflammation characterized by a high amount of macrophages, mast cells and fibrosis. Interestingly, testis macrophage and mast cell infiltration together with fibrosis has also been connected to infertility in men. The aim of the study was to find out whether there are similar changes at the molecular le...

Introduction: We evaluated the efficiency of TESA–ICSI method in infertile men with obstructive azoospermia. Testicular spermatozoa are obtained by fine-needle aspiration of testis (23 G) and than injected into cytoplasm of the oocyte.Methods: In the study, there were 173 married couples with 253 attempts of artificial fertilization (1.45 attempts per couple). Average age of women were 31 years and of men 36 years. Obstructive azoospermia was detect...

Introduction: The 2006 Endocrine Society – testosterone therapy in adult men guidelines were audited against the clinical practice at a UK teaching hospital endocrine department. The aim of the audit was to determine whether patients were undergoing appropriate screening tests for prostate cancer and polycythaemia as described in these guidelines.Method: Patients were initially identified by searching the endocrine clinic letter database for the nam...

Chromosomal translocations or inversions, may cause spermatogenic failure. We present a case of a 35-years-old couple of identical twins: GD and GS. Both had criptorchidism and bilateral varicocele and underwent medical treatment first, and orchipexy and varicocelectomy subsequently at 7 years and 28 years respectively. GD at 31 years had left orchiectomy because of Leydig cell tumor. They were referred to our clinic for azoospermia and fatherhood desire. The patients were a n...

Introduction: Cellular differentiation and development of germ cells critically depend on a coordinated activation and repression of specific genes. The underlying regulation mechanisms, however, are largely unknown. Here, we describe the interplay between two transcription factors to be critical for cell type-specific expression in testis.Methods: We investigated the binding of CREMτ (cAMP response element modulator tau) and GCNF (germ cell nuclear...

To study the efficacy of rhFSH treatment on male infertility we evaluated the response of 79 hypo-normogonadotrophic patients referring to our clinic for couple infertility after a period of not <12–18 months of finalized unprotected intercourse without conception. rhFSH 150 IU were given subcutaneously every other day for 12 months (mean 15±3 months). All men, between 23 and 56 years (mean 34±8 years), were divided into three subgroups: i) hypogonadotropic ...

Introduction: Male hypogonadism is very frequent in men treated with highly active anti-retroviral therapy (HAART) for Human Immunodeficiency Virus-1 (HIV-1) infection, reaching a prevalence of about 20%. Literature data regarding the time course of serum total testosterone (T) levels in these patients are lacking.Aim of the study: To evaluate changes of T levels over time in HIV-positive men with an initial finding of low T (<300 ng/dl).<p class...

Background: Testosterone substitution with favourable kinetics and tolerance is important for hypogonadal men. Intramuscular injections of long-acting testosterone undecanoate (TU) offer a convenient modality.Methods: We report data from 281 patients (134 with primary, 88 with secondary hypogonadism and 59 with late-onset (‘mixed’ or ‘metabolic’) hypogonadism aged 15 to 72 years (mean 40±13 years) receiving altogether 4913 intram...

Objectives: Elderly men often show a concurrence of a decline of testosterone with features of the metabolic syndrome.Materials and methods: One hundred and twenty-two men of a mean age of 59.5±6.0 years, with baseline testosterone 5.9–12.1 nmol/l were treated with parenteral testosterone undecanoate for 42 months as the sole intervention.Results: Plasma testosterone rose from 9.3±1.7 to 18.7±2.1 nmol/l reaching...

Objectives: To investigate the safety of the administration of long-acting parenteral testosterone undecanoate (TU) to hypogonadal, mainly elderly men.Design and methods: One hundred and twenty-two men of a mean age of 59.5±6.0 years, with baseline testosterone 5.9–12.1 nmol/l were treated with parenteral TU. These 122 patients were followed for 42 months.Results: Plasma levels of testosterone rose from 9.3±1.7 to 18...

In this study, we attempted to demonstrate the expression of GHSR-1a receptor and possible effects of its activation in human, rat and boar spermatozoa. For demonstration of GHSR-1a immunocytochemical, immunofluorescence and western blotting techniques were applied. The effects of receptor activation was tested in a series of in vitro incubations of spermatozoa with or without addition of ghrelin and the effects were evaluated using confocal microscopy and flow cytometr...

Introduction: At puberty, the raise of serum estradiol (E2) (after testosterone conversion) is needed to fuse ephiphyses and to complete bone maturation in boys. Owing to severe hypogonadism and very low circulating testosterone, adult men with congenital hypogonadotropic hypogonadism (CHH) may present with unfused epiphyses and continuing linear growth if androgen deficiency is unrecognized and untreated. In order to establish the minimal amount of sex steroids nee...

Aim of the study: Assessing prevalence and severity of erectile dysfunction in patients with pituitary diseases.Materials and methods: International Index of Erectile Function (IIEF) and Sexual Health Inventory for Men (SHIM) questionnaires were used to assess erectile dysfunction (ED) in 83 patients having pituitary diseases (31 patients had hypopituitarism, 11 diabetes insipidus, 10 prolactinomas, 11 nonfunctional adenomas, 16 operated acromegaly, 4 GH...