Endocrine Abstracts

Growth hormon (GH) counteracts the effects of insulin on glucose metabolism and GH excess may lead to insulin resistance (IR). Impaired glucose tolerance (IGT) and diabetes mellitus (DM) are frequently associated with acromegaly. Microalbuminuria (MAU) is a well established cardiovascular (CV) risk factor and a predictor of CV mortality in both diabetic and nondiabetic subjects.The aim of this preliminary study was to investigate the MAU levels as a mark...

Adrenoleukodystrophy has a prevalence rate of 1:20 000 and is a cause of adrenal insufficiency in association with demyelination within the nervous system due to a failure of β-oxidation of fatty acids within peroxisomes due to reduced activity of very long chain acyl-CoA synthetase. Several forms are recognized; a childhood cerebral form (30 to 40% cases), adult adrenomyeloneuropathy (40% cases), and Addison’s disease only (7% cases). Adrenomyeloneuropathy, by contr...

ApoB plays a central role in lipoprotein metabolism through regulation of total cholesterol and LDL-cholesterol (LDL-C) concentrations in plasma. Two restriction fragment length polymorphisms (ECoRI and XbaI) represent single base alterations in the coding region of ApoB gene. ECoRI polymorphic region of ApoB gene is due to on an amino acid change (Glu→Lys). The XbaI polymorphic region of ApoB gene results from a substitution of (A→T) in the threonine codon and doe...

Although the existence of the interaction between sex steroids and immune system is well known, the mechanisms of this interaction are still unclear. Recently a second form of GnRH (GnRH-II) has been described in human, which is significantly expressed in immune tissues suggesting a potential function. In a recent in-vitro study it has been demonstrated that GnRH-II decreases local expression of IL-2R in peripheral lymphocytes (1). However in-vivo interactions of...

Recent studies indicate that atherosclerotic process is associated with bone metabolism. The aim of this study was to evaluate carotid intima media thickness (CIMT) and its association with bone mineral density and bone turnover markers as well as inflammation markers in type 2 diabetic male patients.Material-method: 184 type 2 diabetic males (56±8 y) and 85 non-diabetic control subjects (52±7 y) were recruited. Bone mineral density was measure...

Symptomatic hyperparathyroid patients are under risk of increased cardiovascular mortality, associated with left ventricular hypertrophy, diastolic dysfunction and accelerated atherosclerosis. Data on asymptomatic hyperparathyroid patients are conflicting. This study aimed to determine diastolic dysfunction and its association with carotis intima media thickness (CIMT) and flow-mediated vasodilation (FMD) in a group of asymptomatic hyperparathyroid patients.<p class="abste...

Introduction: Multiple endocrine neoplasia type 2B (MEN 2B) is an aggressive disorder characterized by medullary thyroid cancer (MTC) and pheochromocytoma. Peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTATATE is an effective new treatment for inoperable or metastatic neuroendocrine tumors (NETs). Hematologic problems, myelodysplastic syndrome or leukemia can be seen after alkylating agent and peptide receptor radionuclide therapy treatments. We present metastatic m...

Introduction: Graves’ disease is an autoimmune thyroid disease presenting with hyperthyroidism. In Graves’ disease, there may be diffuse enlargement in the thyroid gland, as well as nodular appearance. The risk of papillary carcinoma should always be kept in mind while the risk of malignancy is low in Graves’ disease.Case presentation: A 50-year-old woman was admitted to our center for a second-time exacerbation of hyperthyroidism in 2015....

Background: Paragangliomas (PGLs) and pheochromocytomas (PCCs) arise from chromaffin cells. We evaluated the inflammatory markers. The pan-immune-inflammation value (PIV) has recently been used as a new marker. Therefore, we evaluated the PIV association in patients with PGLs/PCCs.Methods: In the study, the data of 82 patients with PGLs/PCCs who applied between 2005 and 2020 were collected retrospectively from the records. NLR (neutrophil/lymphocyte rati...

Generously supported by IPSEN)-->Acromegaly is a chronic disease with an important impact on patients, health-related quality of life (HRQoL). Acromegaly quality of life questionnaire (AcroQoL) is a disease-generated QoL questionnaire comprising 22 questions each having five possible responses scored 1–5, the maximum score of 110 reflecting best possible QOL, and quoted as a percentage. The 22 items break down into two categorie...