ECE2007 Poster Presentations (1) (659 abstracts)
Symptomatic hyperparathyroid patients are under risk of increased cardiovascular mortality, associated with left ventricular hypertrophy, diastolic dysfunction and accelerated atherosclerosis. Data on asymptomatic hyperparathyroid patients are conflicting. This study aimed to determine diastolic dysfunction and its association with carotis intima media thickness (CIMT) and flow-mediated vasodilation (FMD) in a group of asymptomatic hyperparathyroid patients.
Twenty six patients with asymptomatic hyperparathyroidism (HP) (23.4±3.9 y; F/M:17/9) and 25 healthy controls (24.4±3.6 y; K/E:18/7) were recruited. Left ventricular mass index (LVMI), isovolumetric relaxation time (IVRT), early (E) and late (A) atrial peak filling velocity were measured by conventional and Doppler echocardiography. Tissue Doppler imaging, a method with better results in determining diastolic dysfunction, was used to determine mitral annular early (E) and late (A) peak diastolic filling rate. FMD and CIMT were determined by Doppler echocardiography. The study was approved by the local Ethical Committee.
|ASYMTOMATIC HP (n=26)||CONTROL (n=25)||P|
LVED, LVMI, IVRT, E/A, E/A and E/E ratios were comparable between groups. PTH was weakly correlated with CIMT (r=−0.26; P=0.23), but not with echocardiographic parameters and FMD.
Diastolic dysfunction was not observed in asymptomatic hyperparathyroid patients. It is evident from this preliminary data that cardiac manifestations do not start at this stage of disease, but further studies with larger groups are needed to confirm this finding.