Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2007) 14 P415

ECE2007 Poster Presentations (1) (659 abstracts)

Evaluation of diastolic function and its relationship with carotis intima media thickness and endothelial function in asymtomatic hyperparathyroid patients

Dilek Yazici 1 , Ozlem Tarcin 1 , Beste Ozben 2 , Ahmet Toprak 2 , Oguzhan Deyneli 1 , Seda Sancak 1 , Dilek Yavuz 1 & Sema Akalin 1


Symptomatic hyperparathyroid patients are under risk of increased cardiovascular mortality, associated with left ventricular hypertrophy, diastolic dysfunction and accelerated atherosclerosis. Data on asymptomatic hyperparathyroid patients are conflicting. This study aimed to determine diastolic dysfunction and its association with carotis intima media thickness (CIMT) and flow-mediated vasodilation (FMD) in a group of asymptomatic hyperparathyroid patients.

Twenty six patients with asymptomatic hyperparathyroidism (HP) (23.4±3.9 y; F/M:17/9) and 25 healthy controls (24.4±3.6 y; K/E:18/7) were recruited. Left ventricular mass index (LVMI), isovolumetric relaxation time (IVRT), early (E) and late (A) atrial peak filling velocity were measured by conventional and Doppler echocardiography. Tissue Doppler imaging, a method with better results in determining diastolic dysfunction, was used to determine mitral annular early (E’) and late (A’) peak diastolic filling rate. FMD and CIMT were determined by Doppler echocardiography. The study was approved by the local Ethical Committee.

Calcium (mg/dL)9.72±0.419.69±0.76NS
Phophorus (mg/dL)3.98±0.663.90±0.40NS
PTH (pg/mL)91.53±24.5042.98±10.69P<0.0001
FMD (%)9.62±3.749.52±3.13NS
CIMT (mm)0.46±0.050.47±0.04NS

LVED, LVMI, IVRT, E/A, E’/A’ and E/E’ ratios were comparable between groups. PTH was weakly correlated with CIMT (r=−0.26; P=0.23), but not with echocardiographic parameters and FMD.

Diastolic dysfunction was not observed in asymptomatic hyperparathyroid patients. It is evident from this preliminary data that cardiac manifestations do not start at this stage of disease, but further studies with larger groups are needed to confirm this finding.

Article tools

My recent searches

No recent searches.