Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2007) 14 P406

ECE2007 Poster Presentations (1) (659 abstracts)

Carotid intima media thickness and bone turnover in type 2 diabetic patients

Seda Sancak 1 , Dilek Yavuz 1 , Ahmet Toprak 2 , Oguzhan Deyneli 1 , Ozlem Tarcin 1 , Dilek Yazici 1 , Hasan Aydin 1 & Sema Akalin 1


1Marmara University Medical School Section of Endocrinology and Metabolism, Istanbul, Turkey; 2Marmara University Medical School Depatment of Internal Medicine, Istanbul, Turkey.

Recent studies indicate that atherosclerotic process is associated with bone metabolism. The aim of this study was to evaluate carotid intima media thickness (CIMT) and its association with bone mineral density and bone turnover markers as well as inflammation markers in type 2 diabetic male patients.

Material-method: 184 type 2 diabetic males (56±8 y) and 85 non-diabetic control subjects (52±7 y) were recruited. Bone mineral density was measured by dual X-ray absorptiometry at lumbar spine and proximal femoral areas. Carotid intima media thickness was evaluated by Doppler ultrasound. Serum osteocalcin, CTX, intact parathyroid hormone (iPTH), hsCRP and HbA1c were measured.

Results are shown in table 1:

Diabetic subjectsControl subjectsP
Serum calcium (mg/dl)9.91±0.49.8±050.03
Serum phosphorus (mg/dl)3.59±0.573.39±0.520.02
Serum PTH (pg/mL) 49.7±2453±22Ns
Osteocalcin (ng/ml)6.8±3.49.5±40.0001
CTX (ng/ml)0.27±0.160.38±0.10.004
hsCRP (mg/L)3.66±42.11±10.01
HbA1c (%)7.02±1.75.1±0.320.0001
Fasting blood glucose (mg/dl)151±6592.62±7.90.0001
Density of Proximal Femur (gr/cm2)0.91±0.10.93±0.10.4
CIMT (mm)0.70±0.160.61±0.230.008

There was a negative correlation between bone mineral content of femur neck and CIMT in diabetic patients (r=−0, 22 P=0.008).

Conclusion: Atherosclerosis and bone mineral density (BMD) may be related through similar or common pathophysiological mechanisms in type 2 diabetics. Low-grade inflammation may be one of the pathologic mechanisms that depressed bone turnover in diabetic patients.

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