Endocrine Abstracts

Introduction and objective: The research was conducted with the aim of highlighting the awareness and understanding of the disease among diabetic patients.Methods: The study included 85 patients with type 2 diabetes, aged 40+ years old, who had been monitoring their blood glucose levels and HbA1c levels in the previous 4 months. Patients were presented a questionnaire with 5 questions about diabetes. The patients’ responses were classified and expre...

Introduction: Diabetes mellitus (DM) is a chronic disease that can be largely managed in the primary care system.Aim: We analysed medical records of diabetic patients (pts) treated in Center for diabetes in our institution, during 1 year, determining the quality of care.Material and methods: The search was focused on pts at first admission to the diabetologist. Analysis included demographic and clinical characteristics of pts, meta...

Background: GLP-1 agonism have the potential to affect gastric emptying (GE), yet the reports for subcutaneous semaglutide, currently the most effective GLP-1 RA approved for weight management, remain inconclusive. It has been demonstrated that semaglutide either had no effect on GE or it delayed GE only within the first hour, without late phase retention. Notably, those conclusions were made by an indirect method of estimation of GE through ingestion, absorption and determina...

Introduction: Antiresorptive treatment can preserve bone mineral density (BMD) in patients with primary hyperparathyroidism (PHPT) when surgery is not feasible or desired. We aimed to compare the impact of zoledronate vs denosumab on bone-related biochemical parameters in this population.Methods: We analyzed preliminary data from our ongoing randomized trial on osteoporotic postmenopausal women with PHPT who are being treated either with zoledronate 5 mg...

Functional interplay between different classes of receptors has emerged as a notable factor of cellular response in health and disease. One of the most prominent examples of cross-talk involves the regulation of glucose metabolism, a major regulatory function under the influence of both insulin receptor (IR) and β2-adrenergic receptor (β2-AR) representing the receptor tyrosine kinases (RTKs) and the seven transmembrane receptors (7TMRs) respecti...

Introduction: Early hyperglycemia in acute pancreatitis (AP) is prognostic sign of severe attack. Elevated lipid levels are one of the major risk factors for AP. The objective of this work was to evaluate the glycaemic and lipid profile in patients (pts) with acute pancreatitis, treated in our institution.Methods: A total of sixty nine pts with AP were admitted to a Department of Internal medicine, from January to December 2012.At ...

Background: Cranial Diabetes Insipidus (CDI) or Arginine-Vasopressin Deficiency (AVP-D) is a potentially life-threatening condition requiring treatment with desmopressin. Omission or delay in desmopressin can result in serious patient harm.Aims: Evaluation of desmopressin prescription/administration practice and implementation of an action plan to improve patient safety.Methods: Re...

Background: Syncope is a transient loss of consciousness resulting from cerebral hypoperfusion. Despite the extensive efforts by the scientific community over decades, the pathophysiology remains unclear. Although syncope itself is a reversible, short-lasting, benign condition, it negatively impacts quality of life. Vasovagal syncope (VVS) is a form of orthostatic intolerance (OI). Its clinical signs such as dizziness and hypotension may mimic symptoms of adrenal insufficiency...

Introduction: Primary hyperparathyroidism (PHPT) is a state of increased bone turnover that can result in secondary osteoporosis. Antiresorptive treatment can be used to preserve bone mineral density (BMD). We compared the impact of zoledronate and denosumab on bone-related biochemical parameters.Methods: We analyzed interim data from our ongoing randomized trial on osteoporotic postmenopausal women with PHPT who are being treated with either zoledronate...

Introduction: To understand the pathological changes associated with glucose homeostasis in old age, it is necessary to know the natural changes in the processing of proinsulin into mature insulin. Surprisingly, while there is abundant information about insulin function in diabetics, the situation in healthy adults and old humans was rarely examined.The study aimed: To determine how the proinsulin secretion in individuals with normal glucose tolerance ch...