Searchable abstracts of presentations at key conferences in endocrinology
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193rd Meeting of the Society for Endocrinology and Society for Endocrinology joint Endocrinology and Diabetes Day

Poster Presentations

Endocrine tumours and neoplasia

ea0004p48 | Endocrine tumours and neoplasia | SFE2002

Prolactin, bilirubin and bile acid concentrations in breast cyst fluid

Sikri S , Szamel I , Ghilchik M , Parish D

Gross cystic disease of the breast is a condition afflicting 7% of western women and confers an increased risk of developing breast cancer. Biochemical analyses of breast cyst fluid (BCF) have allowed the identification of various components of BCF and the classification of breast cysts into type I and II cysts. Gross cystic disease fluid proteins (GCDFP) are a family of proteins found in BCF and include albumin, apolipoprotein D and prolactin inducible protein (PIP). It is pr...

ea0004p49 | Endocrine tumours and neoplasia | SFE2002

Pituitary surgery for Cushing's should be carried out by a specialised neurosurgeon

Collier K , Mendoza N , Barakat M , Todd J , Meeran K

Transphenoidal hypophysectomy is often carried out to remove ACTH-secreting tumours of the pituitary. A postoperative serum cortisol of <50nmol/l usually indicates cure of the disease but after other audits found persistent cases, 'remission' is thought to be a more appropriate term.Charing Cross Hospital is the tertiary neurosurgical centre for West London where a single, dedicated pituitary surgeon was appointed in 1995. We analysed the success of e...

ea0004p50 | Endocrine tumours and neoplasia | SFE2002

No activating point mutation in Cyclin-Dependent Kinase 4 (CDK4) in pituitary adenomas, insulinomas and Leydig cell tumours

Bibi R , Diaz-Cano S , Vax V , Gueorguiev M , Kola B , Bressac B , Walker G , Grossman A , Korbonits M

BACKGROUND: Cell cycle dysregulation is one of the defining features of cancer. Cyclin-dependent kinase 4 (CDK4), together with its regulatory subunit Cyclin D, governs cell cycle progression in G1 phase. CDK4 is in turn regulated by cyclin-dependent kinase inhibitors, including p16INK4A (CDKN2A). Dysregulation of the INK4A/CDK4/cyclin D complex has been established in different a variety of types of human tumours. Dominant mutations affecting codon 24 of the CDK4 gene (replac...

ea0004p51 | Endocrine tumours and neoplasia | SFE2002

Making the diagnosis of Cushing's disease: A cautionary tale

Collier K , Jackson J , Mendoza N , Barakat M , Todd J , Meeran K

Eliciting an accurate diagnosis of Cushing's disease before transphenoidal hypophysectomy is essential to avoid unnecessary surgery. Localisation of the tumour increases the chance of operative success.In the right hands, Inferior Petrosal Sinus Sampling (IPSS) can provide invaluable information in distinguishing ectopic ACTH from pituitary Cushing's and localising the tumour in patients who are known to have Cushing's syndrome. Due to the invasive natur...

ea0004p52 | Endocrine tumours and neoplasia | SFE2002

No evidence of a role for mutations in the cAMP-dependant Protein Kinase A regulatory subunit in hyperfunctioning adrenocortical adenomas

Swords F , Arola J , Clark A

The molecular mechanisms underlying adrenal adenomas have not yet been elucidated. Many groups have sought mutations within the ACTH receptor as well as its downstream signalling pathway, although none have yet been identified. However, mutations in the alpha regulatory subunit of the cAMP dependant Protein Kinase A (PRKAR1A) have recently been described in more than 50% of patients with Carney complex. This syndrome is characterised by nodular adrenocortical hyperplasia as we...

ea0004p53 | Endocrine tumours and neoplasia | SFE2002

Midnight Cortisol Revisited

Noimark D , Barakat M , Meeran K , Todd J

Midnight Cortisol RevisitedD Noimark, MT Barakat, K. Meeran, JF ToddEndocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, LondonBackground: The diagnosis of Cushing's syndrome must be established before any attempt at differential diagnosis. The diagnosis of Cushing's syndrome can be made initially on an outpatient basis with the measurement of 24 hour urinary free cortisol ...

ea0004p54 | Endocrine tumours and neoplasia | SFE2002

Cushing's syndrome due to an adrenocortical carcinoma

Nag S , McCulloch A

Primary adrenal tumours are responsible for about 10% of cases of Cushing's syndrome. Adrenocortical carcinomas are rare with an incidence of 2 per million per year. Both adrenocortical adenomas and carcinomas occur more commonly in women.A 46 year old previously fit woman presented with a short history of hirsutism, facial plethora, amenorrhoea, acne and progressive weight gain. Hypertension and glucose intolerance had been diagnosed recently. There was...

ea0004p55 | Endocrine tumours and neoplasia | SFE2002

Improved 5 year actuarial survival rates in patients with prostate cancer managed by intermittent androgen suppression

Lane T , Ansell W , Oliver R

INTRODUCTIONWe assessed the long-term outcomes of patients managed with intermittent androgen suppression (IAS) following their enrolment in an open, non-randomised feasibility study initiated 10 years ago.PATIENTS AND METHODSAll patients were required to have been managed with androgen suppression for a minimum of 9 months and achieved PSA remissions to levels <4ng/ml. Therapy was stopped and the patients...

ea0004p56 | Endocrine tumours and neoplasia | SFE2002

Acromegaly: Treatment outcomes and relationship of Growth Hormone (GH) to IGF-1

Kodali V , Sibal L , Connolly V , Kelly W

Aim: To ascertain the types of treatment, results and correlation between GH and the simultaneous IGF-1. Setting: Endocrine and Neurosurgical Unit. Methods: Endocrine and laboratory database of 17 acromegalic patients (11 male) with mean (SD) age 51(3) years and follow up 11 years. Results: Pituitary surgery 11 patients (3 twice), external radiotherapy 10 (one heavy particle therapy). GH levels have come down from a median value 32.5 mU per litre (Mean plus/minus SEM: 51.9 plu...

ea0004p57 | Endocrine tumours and neoplasia | SFE2002


Razvi S , Wright M , Weaver J

Introduction:The genetics of most cases of familial phaechromocytomas is unknown.Up to 50%of paragangliomas arefamilial and increased susceptibility is seen in SDHD and SDHC mutations.We report a family with a mutation in the SDHB gene .Case report: The index case, a 22 year old male was treated at the age of 10 years with extra adrenal phaeochromocytoma. Recently, he was found to have ...

ea0004p58 | Endocrine tumours and neoplasia | SFE2002

Chasing a parathyroid adenoma

Banerjee M , Hearn A , Vice P

This 65 years old lady, who had undergone neck explorations for parathyroid adenoma in 1972 and 2000, presented with vomiting, lethargy, muscle weakness and polyuria. On admission, her serum Calcium was 2.98 mmol/l (2.18-2.63) with elevated parathyroid hormone of 151 pg/ml (10-70). A Thallium-Technetium parathyroid scan was normal but Octreotide scan showed an area of uptake in the superior mediastinum. A MIBI scan followed, which was unhelpful as were ultrasound scan of the n...

ea0004p59 | Endocrine tumours and neoplasia | SFE2002


Pulatova N

AIM: to study the adequacy of surgery and detect MTC recurrences by means of serum calcitonin.METHODS: 30 patients with MTC were examined and followed-up for 5.5 years in the average. Radio-inmmunological examination, serum CT measurement was performed by means of commercially available kit RIA DCL-1200. Norm is up to 42picograms per ml.RESULTS: as the result of analysis of the surgery types MTC prognosis parameters, such as, tumor...

ea0004p60 | Endocrine tumours and neoplasia | SFE2002

Modulation of Estrogen Receptor function- the role of co-regulatory proteins

Fleming F , Hill A , Mc|#Dermott E , O'Higgins N , Young L

ER-alpha and ER-beta function as transcription factors to modulate expression of target genes. Both interact with nuclear regulatory proteins to enhance or inhibit transcription. We hypothesized that these co-regulators are expressed in breast cancer tissue and may be differentially regulated by estrogen and tamoxifen.ER-alpha, ER-beta, the co-activator SRC-1, and the co-repressor SMRT were localized within breast tissue by immunohistochemistry, and the ...

ea0004p61 | Endocrine tumours and neoplasia | SFE2002

Inhibition of Ovarian Cancer Cell Growth by 2-Methoxyoestradiol-6-oxime

Fishman L , Bennetto D , Leese M , Purohit A , Potter B , Reed M

Ovarian cancer is the leading cause of death from all gynaecological malignancies. The observation that decreased levels of the natural oestrogen-17beta metabolite, 2-methoxyoestradiol (2-MeOE2) may create a predisposition to oestrogen dependent cancer, has led to considerable interest in the potential use of oestrogen derivatives for the prevention and treatment of hormone dependent cancers. The sulphamoylated oestrone derivative 2-methoxyoestrone-3-O-sulphamate (2-MeO...

ea0004p62 | Endocrine tumours and neoplasia | SFE2002

Cross-sectional study of Quality of Life (QOL) in patients with Acromegaly

Rowles S , Webb S , Lee C , Shalet S , Trainer P

Advances in the treatment of acromegaly mean biochemical 'cure ' should be possible in the vast majority of patients. The challenge of the future will be designing treatment algorithms to optimise outcomes for individual patients, to ensure not only life expectancy but also QOL is normalised. QOL data is lacking in acromegaly, as is a disease-specific tool for measuring QOL. ACROQOL is a disease-specific QOL questionnaire compromising 22 questions (scored 1-5, high score good)...

ea0004p63 | Endocrine tumours and neoplasia | SFE2002

Asymptomatic neuroendocrine pancreatic tumours associated with Multiple Endocrine Neoplasia type 1: what to do?

Monteiro M , Carvalho R , Cavaco B , Cardoso H , Castro R , Santos M , Costa M , Correia M , Ramos H

Background: The screening of patients and relatives for the presence of inactivating mutations of the MEN 1 gene, established quite accurately those for prospective detection of neoplasms. Active search for pancreatic lesions has increased the detection of neuroendocrine pancreatic tumours (NEPT) at early ages, most asymptomatic and with no signs of malignancy at diagnosis.Case Report: We describe one kindred where five members were identified as carrier...

ea0004p64 | Endocrine tumours and neoplasia | SFE2002

The differential expression of 22kDa and 20kDa growth hormone isomers in normal and malignant colon and breast tissue

Mistry R , Kelly P , Ogunkolade B , Bustin S , Jenkins P

Background. The GH/IGF-I axis has been implicated in the pathogenesis of colon and breast cancer. We have recently demonstrated that the local expression of its components correlates with that of tumour-associated genes and angiogenesis. The two predominant isomers of GH in humans are 22kDa and 20kDa isomers. A recent study reported that the two isomers exert opposing effects on breast cancer cells: 22kDa GH promotes proliferation whereas 20kDa GH inhibits proliferation. The l...