Endocrine Abstracts

Introduction: In lambs, the rapid increase in heat production after birth is due to the initiation of nonshivering thermogenesis in brown adipose tissue (BAT). This occurs in conjunction with an increase in amount and activity of the BAT specific uncoupling protein 1 (UCP1). Both mRNA and protein for the long and short forms of the prolactin receptor are highly abundant in ovine BAT up to the time of birth. The following study aimed to determine whether prolactin administratio...

Introduction: Maternal dexamethasone (DEX) treatment is known to promote thermoregulation in the newborn lamb by increasing the amount of uncoupling protein 1 (UCP1). The extent to which the IGF axis within adipose tissue (AT) may be altered following such treatment is not known.Methods: Eight triplet bearing ewes were entered into the study, 5 of which were injected with 16 micrograms of DEX at 138 days of gestation (term = 147 days). Caesarean section ...

Androgen, a key endocrine factor that drives normal prostate gland growth, is implicated in the progression of prostate cancer and benign prostate hyperplasia. However, failure to adapt androgen ablation therapy for the treatment of prostatic diseases cast doubts on our understanding of androgen role in the regulation of normal and abnormal prostate gland growth. This study was conducted to gain further insight into the role of androgen in maintaining a balanced prostatic cell...

Effect of GABA agonist on mean concentrations of growth hormone, thyroxine, triiodothyronine in the womenH Khazali, University of Tarbiat Modarres, Tehran, IranThe goal of this study was to determine whether injections ofGABA agonist increase the plasma concentration of thyroxine (T4) ,triiodothyronine (T3)and growth hormone (GH) in the women. Subgects were randomly divide into 4 groups...