ea0006oc18 | Growth and Development | SFE2003
, Howie A
, Morley S
, Payne A
, Mason J
3beta-hydroxysteroid dehydrogenase (3beta-HSD) expression is essential for the synthesis of all classes of steroid hormones, converting delta5beta-hydroxysteroids into hormonally active delta4-3-ketosteroids in NAD+-dependent reactions. Numerous 3beta-HSD isoforms have been described in mouse, rat, human and other mammals, all with distinct tissue and developmentally specific expression, distinct kinetics, with alternative substrate specificity...