Endocrine Abstracts

Growth hormone (GH) is the major regulator of postnatal growth and an important metabolic regulator. It modulates a variety of processes in many tissues, ranging from adipogenesis to neurogenesis and immune function.GH is currently thought to activate its receptor through hormone-induced dimerization, resulting in activation of the Janus kinase, JAK2. However, we find that the receptor exists as a dimer in the plasma membrane before hormone binding, base...

Mike Waters, Institute for Molecular Bioscience, University of Queensland, St Lucia, Australia AbstractProfessor Mike Waters is an NHMRC Principal Research Fellow at the Institute for Molecular Bioscience and School of Biomedical Sciences, University of Queensland. Mike has been involved in the study of GH action for over 30 years. It was his pioneering work in purifying and characterizing the GH receptor, its related ...