Endocrine Abstracts

Introduction: Lack of radioiodine uptake in Differentiated Thyroid Carcinoma is a huge diagnostic and therapeutic problem. This sign is associated with worse prognosis. DOTA-TATE preparation is a somatostatin analogue coupled with ⁹⁰ Y which emites β (−) radiation. Its use in a treatment depends on excessive expression of somatostatin receptors (SSTR) in malignant tumours.

The aim of the study: To present a possibility of treatment of non iodine – avid dissemnated papillary thyroid cancer with ⁹⁰Y-DOTA-TATE preparation. The local Ethical Committee approval has been obtained before.

Material and methods: 73 y. o. male with dissemnated non-radioiodine - avid papillary thyroid cancer has been treated by ⁹⁰Y-DOTA-TATE. Presence of SSTR was confirmed with use of ^99mTc-HYNIC-TATE (Tektrotyd) preparation earlier. Both of these radiopreparations are produced by POLATOM – Swierk/Poland. In March, April and July 2005 this patient was treated with the ⁹⁰Y-DOTA-TATE three times (3.7 GBq per dose). Nephroprotection was obtained by 10 hours infusion of 1000 ml 10% amino acids preparation with max. speed 120 ml/h.

Results: There wern’t observed any serious adverse events after ⁹⁰Y-DOTA-TATE treatment. Non significant, transient decrease of thrombocytes and lymphocytes was observed. Thyreoglobuline serum concentration increase was considered as a sign of cancer destruction. The reduction of neoplasm infiltrations in site of thyroid removal and in mediastinum and lungs in CT scans was observed two months after the third ⁹⁰Y-DOTA-TATE injection. Histopathological estimation of excised the new superficial meta tumours of the neck region showed mainly necrosis and calcifications.

Conclusions: ⁹⁰Y-DOTA-TATE preparation seems to be useful and promising in treatment of non – radioiodine – avid papillary thyroid cancer.