Searchable abstracts of presentations at key conferences in endocrinology
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9th European Congress of Endocrinology

Oral Communications

Bone & calcium metabolism

ea0014oc2.1 | Bone & calcium metabolism | ECE2007

Effect of once-yearly infusion of zoledronic acid 5 mg in postmenopausal women with osteoporosis

Eastell Richard , Lakatos Peter , Black Dennis , Boonen Steven , Cosman Felicia , Cumings Steven , Delmas Pierre , Eriksen Erik Fink , Leung Ping Chung , Man Zulema , Mesenbrink Peter , Reid Ian , Cauley Jane

Background and methods: The HORIZON-PFT is a multinational, 3-year, randomized, double-blind, placebo-controlled trial evaluating the potential of once-yearly zoledronic acid (ZOL) 5 mg, infused over 15 minutes, to decrease risk of fracture in 7736 postmenopausal osteoporotic women 65–89 years of age.Results: Treatment with ZOL 5 mg resulted in significant relative risk reductions in morphometric vertebral fracture of 70% vs PBO (3.8% vs 12.8%; 95% ...

ea0014oc2.2 | Bone & calcium metabolism | ECE2007

Role of IGF system on the regulation of osteoblast aromatase activity in vitro

Palermo Claudia , Arvigo Marica , Minuto Francesco

Several studies demonstrated that IGFs stimulate aromatase activity in ovary but no data on bone are available. In the present study the role of IGF system components on aromatase action has been characterized during osteogenic differentiation in a model of rat tibial osteoblasts. At confluence (day 0) cells have been transferred to differentiating medium supplemented with 1% FCS and delta4androstenedion with or without IGF-II 3 nM, IGFBP-2 1 nM and IGFBP-3 1 nM. Cells have be...

ea0014oc2.3 | Bone & calcium metabolism | ECE2007

Clinical and biochemical differences in patients affected with sporadic and type 1 multiple endocrine neoplasia (MEN) related primary hyperparathyroidism

Eller-Vainicher Cristina , Massironi Sara , Peracchi Maddalena , Persani Luca , Beck-Peccoz Paolo , Spada Anna , Corbetta Sabrina

Primary hyperparathyroidism (PHPT) may occur sporadically or within MEN syndromes. It is classically thought that PHPT in MEN occurs at earlier ages than sporadic PHPT without significant differences in clinical and biochemical presentation. The aim of the study was to compare clinical and biochemical parameters between sporadic PHPT and MEN1 patients. The study included 41 genetically diagnosed MEN1 patients (14M, 27F) and 88 sporadic PHPT patients (24M, 64F) matched for age ...

ea0014oc2.4 | Bone & calcium metabolism | ECE2007

Assessment of prevalent vertebral deformities in morphometric X-ray absorptiometry

Skowronska-Jozwiak Elzbieta , Pludowski Pawel , Karczmarewicz Elzbieta , Lewinski Andrzej , Lorenc Roman

Vertebral morphometric X-ray absorptiometry (MXA) is a new tool developed to evaluate the presence of vertebral deformities. Low dose of radiation, fan-beam and the centerline scan technique are believes more advantageous than the classic morphometry using conventional lateral radiograms. We assessed the prevalence of vertebral fractures by MXA in adult population of &Lstrok;ód&zacute; region as a part of Polish population studied in EPOLOS epidemiological study.<p cl...

ea0014oc2.5 | Bone &amp; calcium metabolism | ECE2007

Effect of gonadal status on baseline and after rhGH treatment prevalence of spinal deformities in adult patients with growth hormone deficiency (GHD)

Mazziotti Gherardo , Bianchi Antonio , Bonadonna Stefania , Nuzzo Monica , Cimino Vincenzo , Fusco Alessandra , Marinis Laura De , Giustina Andrea

Adult GHD patients may have reduced BMD, which is thought to be reverted by long-term rhGH replacement therapy. We have recently reported high prevalence of vertebral osteoporotic deformities in untreated adult GHD patients. Gonadal status is the main determinant of bone loss in patients with primary form of osteoporosis.In this cross-sectional study, we investigated whether the prevalence and degree of spinal deformities in adults with treated or untrea...

ea0014oc2.6 | Bone &amp; calcium metabolism | ECE2007

Sunlight exposure and vitamin D supplementation at the institutionalized elderly – effects on calcium and bone metabolism

Bottermann Peter , Branisteanu Dumitru , Mogos Voichita , Zbranca Eusebie

We investigated calcium and bone metabolism in a group of 123 institutionalized volunteers between 60 and 98 years old, 73 females and 50 males. 25OH-D3 was measured by an indoor RIA technique. 1.25(OH)2D3 was measured by HPLC, serum calcium by photocolorimetry, bone alkaline phosphatase by immunoenzymatic technique, whereas serum PTH and urinary deoxypyridinoline (DPD) were measured by IRMA. Almost all volunteers (92.6%) had low 25OH-D3</...

ea0014oc2.7 | Bone &amp; calcium metabolism | ECE2007

Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells

Horie-Inoue Kuniko , Ichikawa Tomoe , Inoue Satoshi

Vitamin K is known as a critical cofactor in blood coagulation and bone homeostasis by helping the function of vitamin K-dependent gamma-carboxylase. We have recently shown that vitamin K2, one of the natural vitamin Ks, has a novel function to regulate the transcription of extracellular matrix-related genes in osteoblastic cells and increase collagen accumulation by activating the steroid and xenobiotic receptor, SXR. In the present study, we searched for novel vitamin K targ...